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35 relations: Amblyopia, André Barbeau, Aromatic L-amino acid decarboxylase, Aromatic L-amino acid decarboxylase inhibitor, Basal ganglia, Benserazide, Blood–brain barrier, British Approved Name, Brookhaven National Laboratory, Carbidopa, Carbidopa/levodopa/entacapone, Central nervous system, Developing country, Dopamine, DuPont, Dyskinesia, Entacapone, Enzyme, Gastrointestinal tract, Generic drug, George Cotzias, Health system, Hoffmann-La Roche, L-DOPA, Merck & Co., Oleh Hornykiewicz, Orthostatic hypotension, Parkinson's disease, Psychosis, Racemic mixture, Restless legs syndrome, Segawa Syndrome, Stereoisomerism, University of Vienna, WHO Model List of Essential Medicines.
Amblyopia
Amblyopia, also called lazy eye, is a disorder of sight due to the eye and brain not working well together.
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André Barbeau
André Barbeau, (27 May 1931 – 9 March 1986) was a French Canadian neurologist.
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Aromatic L-amino acid decarboxylase
Aromatic L-amino acid decarboxylase (AADC or AAAD), also known as DOPA decarboxylase (DDC), tryptophan decarboxylase, and 5-hydroxytryptophan decarboxylase, is a lyase enzyme.
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Aromatic L-amino acid decarboxylase inhibitor
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AADC, AAAD, or DOPA decarboxylase).
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Basal ganglia
The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.
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Benserazide
Benserazide (also called Serazide or Ro 4-4602) is a peripherally-acting aromatic L-amino acid decarboxylase (AADC) or DOPA decarboxylase inhibitor, which is unable to cross the blood–brain barrier.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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British Approved Name
A British Approved Name (BAN) is the official non-proprietary or generic name given to a pharmaceutical substance, as defined in the British Pharmacopoeia (BP).
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Brookhaven National Laboratory
Brookhaven National Laboratory (BNL) is a United States Department of Energy national laboratory located in Upton, New York, on Long Island, and was formally established in 1947 at the site of Camp Upton, a former U.S. Army base.
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Carbidopa
Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa.
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Carbidopa/levodopa/entacapone
Carbidopa/levodopa/entacapone, sold under the brand name Stalevo, is an anti-parkinsonian dopaminergic combination medication that contains carbidopa, levodopa, and entacapone for the treatment of Parkinson's disease.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Developing country
A developing country (or a low and middle income country (LMIC), less developed country, less economically developed country (LEDC), underdeveloped country) is a country with a less developed industrial base and a low Human Development Index (HDI) relative to other countries.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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DuPont
E.
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Dyskinesia
Dyskinesia refers to a category of movement disorders that are characterized by involuntary muscle movements, including movements similar to tics or chorea and diminished voluntary movements.
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Entacapone
Entacapone, sold under the brand name Comtan among others, is a medication commonly used in combination with other medications for the treatment of Parkinson's disease.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Gastrointestinal tract
The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.
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Generic drug
A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.
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George Cotzias
George Constantin Cotzias (June 16, 1918 in Chania, Crete – June 13, 1977 in New York City) was a Greek-American scientist who together with his coworkers developed L-Dopa treatment, currently the most commonly used treatment for Parkinson's disease.
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Health system
A health system, also sometimes referred to as health care system or as healthcare system, is the organization of people, institutions, and resources that deliver health care services to meet the health needs of target populations.
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Hoffmann-La Roche
F.
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L-DOPA
L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.
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Merck & Co.
Merck & Company, Inc., d.b.a. Merck Sharp & Dohme (MSD) outside the United States and Canada, is an American pharmaceutical company and one of the largest pharmaceutical companies in the world.
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Oleh Hornykiewicz
Oleh Hornykiewicz (born 17 November 1926) is an Austrian biochemist.
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Orthostatic hypotension
Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Psychosis
Psychosis is an abnormal condition of the mind that results in difficulties telling what is real and what is not.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Restless legs syndrome
Restless legs syndrome (RLS) is a disorder that causes a strong urge to move one's legs.
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Segawa Syndrome
Segawa Syndrome (SS) also known as Dopamine-responsive dystonia (DRD), Segawa's disease, Segawa's dystonia and hereditary progressive dystonia with diurnal fluctuation, is a genetic movement disorder which usually manifests itself during early childhood at around ages 5–8 years (variable start age).
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Stereoisomerism
In stereochemistry, stereoisomers are isomeric molecules that have the same molecular formula and sequence of bonded atoms (constitution), but differ in the three-dimensional orientations of their atoms in space.
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University of Vienna
The University of Vienna (Universität Wien) is a public university located in Vienna, Austria.
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WHO Model List of Essential Medicines
The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.
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Redirects here:
Apo-Levocarb, Atamet, Carbidopa-levodopa, Cinemet, Co-careldopa, Duodopa, Levocarb, Levodopa-carbidopa, Levodopa/carbidopa, Parcopa, Sinemet, Sinemet cr, Sinimet.
References
[1] https://en.wikipedia.org/wiki/Carbidopa/levodopa
