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Radical SAM

Index Radical SAM

Radical SAM is a designation for a superfamily of enzymes that use a + cluster to reductively cleave S-adenosyl-L-methionine (SAM) to generate a radical, usually a 5′-deoxyadenosyl radical, as a critical intermediate. [1]

36 relations: Aminoglycoside, Antimicrobial resistance, Biotin, Blasticidin S, Chlorophyll, Coenzyme F420, Cofactor (biochemistry), Cysteine, Deoxyadenosyl radical, Diphthamide, DNA repair, Heme, Hidden Markov model, Hydrogenase, Lysine 2,3-aminomutase, Macrolide, Metalloprotein, Methyl radical, Molybdenum cofactor, Mycofactocin, Nosiheptide, Osmolyte, Peptide, Pfam, Phosphonate, Post-transcriptional modification, Post-translational modification, Pyrroloquinoline quinone, Pyrrolysine, Radical (chemistry), Ribosomal RNA, S-Adenosyl methionine, Spore photoproduct lyase, Thiamine, Transfer RNA, Vitamin K2.


Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agents that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar); the term can also refer more generally to any organic molecule that contains aminosugar substructures.

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Antimicrobial resistance

Antimicrobial resistance (AMR or AR) is the ability of a microbe to resist the effects of medication that once could successfully treat the microbe.

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Biotin is a water-soluble B vitamin, also called vitamin B7 and formerly known as vitamin H or coenzyme R. Biotin is composed of a ureido ring fused with a tetrahydrothiophene ring.

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Blasticidin S

Blasticidin S is an antibiotic that is produced by Streptomyces griseochromogenes.

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Chlorophyll (also chlorophyl) is any of several related green pigments found in cyanobacteria and the chloroplasts of algae and plants.

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Coenzyme F420

Coenzyme F420 or 8-hydroxy-5-deazaflavin is a coenzyme involved in redox reactions in methanogens, in many Actinobacteria, and sporadically in other bacterial lineages.

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Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.

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Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Deoxyadenosyl radical

Deoxyadenosyl radical is a free radical that is structurally related to adenosine by removal of a 5'-hydroxy group from adenosine.

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Diphthamide is a post-translationally modified histidine amino acid found in archaeal and eukaryotic elongation factor 2 (eEF-2).

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

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Heme or haem is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands.

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Hidden Markov model

Hidden Markov Model (HMM) is a statistical Markov model in which the system being modeled is assumed to be a Markov process with unobserved (i.e. hidden) states.

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A hydrogenase is an enzyme that catalyses the reversible oxidation of molecular hydrogen (H2), as shown below: Hydrogen uptake is coupled to the reduction of electron acceptors such as oxygen, nitrate, sulfate, carbon dioxide, and fumarate.

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Lysine 2,3-aminomutase

Lysine 2,3-aminomutase (KAM or LAM) is a radical SAM enzyme that facilitates the conversion of the amino acid lysine to beta-lysine.

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The macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached.

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Metalloprotein is a generic term for a protein that contains a metal ion cofactor.

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Methyl radical

Methyl (also systematically named trihydridocarbon) is an organic compound with the chemical formula (also written as •).

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Molybdenum cofactor

Molybdenum cofactor has two meanings, which are sometimes used interchangeably.

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Mycofactocin is a ribosomally synthesized and post-translationally modified peptide, or RiPP.

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Nosiheptide is a thiopeptide antibiotic produced by the bacterium Streptomyces actuosus.

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Osmolytes are compounds affecting osmosis.

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Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

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Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models.

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Phosphonates and phosphonic acids are organophosphorus compounds containing C−PO(OH)2 or C−PO(OR)2 groups (where R.

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Post-transcriptional modification

Post-transcriptional modification or Co-transcriptional modification is the process in eukaryotic cells where primary transcript RNA is converted into mature RNA.

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Post-translational modification

Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.

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Pyrroloquinoline quinone

Pyrroloquinoline quinone (PQQ) is redox cofactor.

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Pyrrolysine (symbol Pyl or O; encoded by the 'amber' stop codon UAG) is an ɑ-amino acid that is used in the biosynthesis of proteins in some methanogenic archaea and bacteria; it is not present in humans.

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Radical (chemistry)

In chemistry, a radical (more precisely, a free radical) is an atom, molecule, or ion that has an unpaired valence electron.

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Ribosomal RNA

Ribosomal ribonucleic acid (rRNA) is the RNA component of the ribosome, and is essential for protein synthesis in all living organisms.

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S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation.

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Spore photoproduct lyase

Spore photoproduct lyase (SAM, SP lyase, SPL, SplB, SplG) is a radical SAM enzyme that repairs a particular kind of lesion that arises upon UV-radiation of bacterial DNA.

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Thiamine, also known as thiamin or vitamin B1, is a vitamin found in food, and manufactured as a dietary supplement and medication.

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Transfer RNA

A transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length, that serves as the physical link between the mRNA and the amino acid sequence of proteins.

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Vitamin K2

Vitamin K2 or menaquinone has nine related compounds, generally subdivided into the short-chain menaquinones (with MK-4 as the most important member) and the long-chain menaquinones, of which MK-7, MK-8 and MK-9 are nutritionally the most recognized.

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[1] https://en.wikipedia.org/wiki/Radical_SAM

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