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S-Adenosyl methionine

Index S-Adenosyl methionine

S-Adenosyl methionineSAM-e, SAMe, SAM, S-Adenosyl-L-methionine, AdoMet, ademetionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. [1]

65 relations: Adenosine, Adenosine triphosphate, Adenosylhomocysteinase, Adenosylmethionine decarboxylase, Adrenaline, Alkylation, Amyotrophic lateral sclerosis, Anabolism, Anxiety, Bipolar disorder, Canada, Cirrhosis, Cobalamin, Congenital heart defect, Cysteine, Deoxyadenosyl radical, Dextromethorphan, Dietary supplement, Dietary Supplement Health and Education Act of 1994, DNA methyltransferase, Epigenetics, Ethylene, Formate C-acetyltransferase, Giulio Cantoni, Homocysteine, Indigestion, Insomnia, L-DOPA, Levomefolic acid, Lipid, List of investigational antidepressants, Liver disease, Lysine 2,3-aminomutase, Major depressive disorder, Messenger RNA, Metalloprotein, Methionine, Methionine synthase, Methyl group, Methyltransferase, Model organism, Nucleic acid, Nucleotide, Osteoarthritis, Pentazocine, Pethidine, Phytochemistry (journal), Polyamine, Prescription drug, Protein, ..., Putrescine, Radical SAM, S-Adenosyl-L-homocysteine, S-Adenosylmethioninamine, S-adenosylmethionine synthetase enzyme, SAM riboswitch (S box leader), Secondary metabolite, Serotonin syndrome, Spermidine, Spermine, Spore photoproduct lyase, Tramadol, Transfer RNA, Transsulfuration pathway, United States. Expand index (15 more) »


Adenosine is both a chemical found in many living systems and a medication.

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Adenosine triphosphate

Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.

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Adenosylhomocysteinase (S-adenosylhomocysteine synthase, S-adenosylhomocysteine hydrolase, adenosylhomocysteine hydrolase, S-adenosylhomocysteinase, SAHase, AdoHcyase) is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine.

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Adenosylmethionine decarboxylase

Adenosylmethionine decarboxylase is an enzyme that catalyzes the conversion of ''S''-adenosyl methionine to ''S''-adenosylmethioninamine.

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Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.

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Alkylation is the transfer of an alkyl group from one molecule to another.

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Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND), and Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.

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Anabolism (from ἁνά, "upward" and βάλλειν, "to throw") is the set of metabolic pathways that construct molecules from smaller units.

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Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.

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Bipolar disorder

Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.

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Canada is a country located in the northern part of North America.

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Cirrhosis is a condition in which the liver does not function properly due to long-term damage.

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Cobalamin (Cbl) is a general term that is referred to a number of compounds, that have cobalt ion in the middle, hence the name of the compound.

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Congenital heart defect

A congenital heart defect (CHD), also known as a congenital heart anomaly or congenital heart disease, is a problem in the structure of the heart that is present at birth.

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Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Deoxyadenosyl radical

Deoxyadenosyl radical is a free radical that is structurally related to adenosine by removal of a 5'-hydroxy group from adenosine.

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Dextromethorphan (DXM or DM) is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).

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Dietary supplement

A dietary supplement is a manufactured product intended to supplement the diet when taken by mouth as a pill, capsule, tablet, or liquid.

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Dietary Supplement Health and Education Act of 1994

The Dietary Supplement Health and Education Act of 1994 ("DSHEA"), is a 1994 statute of United States Federal legislation which defines and regulates dietary supplements.

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DNA methyltransferase

In biochemistry, the DNA methyltransferase (DNA MTase) family of enzymes catalyze the transfer of a methyl group to DNA.

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Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.

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Ethylene (IUPAC name: ethene) is a hydrocarbon which has the formula or H2C.

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Formate C-acetyltransferase

In enzymology, formate C-acetyltransferase (pyruvate formate lyase, PFL) is an enzyme.

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Giulio Cantoni

Giulio Leonardo Cantoni (29 September 1915 – 25 July 2005) was the director of the United States' National Institutes of Health's Laboratory of Cellular Pharmacology, later renamed the Laboratory of General and Comparative Biochemistry.

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Homocysteine is a non-proteinogenic α-amino acid.

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Indigestion, also known as dyspepsia, is a condition of impaired digestion.

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Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.

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L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.

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Levomefolic acid

Levomefolic acid (INN) (also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine.

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In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.

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List of investigational antidepressants

This is a list of investigational antidepressants, or antidepressants that are currently under development for clinical use in the treatment of mood disorders but are not yet approved.

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Liver disease

Liver disease (also called hepatic disease) is a type of damage to or disease of the liver.

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Lysine 2,3-aminomutase

Lysine 2,3-aminomutase (KAM or LAM) is a radical SAM enzyme that facilitates the conversion of the amino acid lysine to beta-lysine.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Metalloprotein is a generic term for a protein that contains a metal ion cofactor.

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Methionine (symbol Met or M) is an essential amino acid in humans.

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Methionine synthase

Methionine synthase also known as MS, MeSe, MetH is responsible for the regeneration of methionine from homocysteine.

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Methyl group

A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms — CH3.

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Methyltransferases are a large group of enzymes that all methylate their substrates but can be split into several subclasses based on their structural features.

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Model organism

A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.

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Nucleic acid

Nucleic acids are biopolymers, or small biomolecules, essential to all known forms of life.

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Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and underlying bone.

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Pentazocine, sold under the brand name Talwin among others, is a painkiller used to treat moderate to severe pain.

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Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class.

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Phytochemistry (journal)

Phytochemistry is a peer-reviewed scientific journal covering pure and applied plant chemistry, plant biochemistry and molecular biology.

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A polyamine is an organic compound having more than two amino groups.

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Prescription drug

A prescription drug (also prescription medication or prescription medicine) is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Putrescine, or tetramethylenediamine, is a foul-smelling organic chemical compound NH2(CH2)4NH2 (1,4-diaminobutane or butanediamine) that is related to cadaverine; both are produced by the breakdown of amino acids in living and dead organisms and both are toxic in large doses.

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Radical SAM

Radical SAM is a designation for a superfamily of enzymes that use a + cluster to reductively cleave S-adenosyl-L-methionine (SAM) to generate a radical, usually a 5′-deoxyadenosyl radical, as a critical intermediate.

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S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative used in several metabolic pathways in most organisms.

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S-Adenosylmethioninamine (decarboxylated ''S''-adenosyl methionine) is a substrate that is involved in the biosynthesis of polyamines including spermidine, spermine, and thermospermine.

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S-adenosylmethionine synthetase enzyme

S-adenosylmethionine synthetase (also known as methionine adenosyltransferase (MAT)) is an enzyme that creates S-adenosylmethionine (a.k.a. AdoMet, SAM or SAMe) by reacting methionine (a non-polar amino acid) and ATP (the basic currency of energy).

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SAM riboswitch (S box leader)

The SAM riboswitch (also known as the S-box leader and now also called the SAM-I riboswitch) is found upstream of a number of genes which code for proteins involved in methionine or cysteine biosynthesis in Gram-positive bacteria.

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Secondary metabolite

Secondary metabolites are organic compounds that are not directly involved in the normal growth, development, or reproduction of an organism.

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Serotonin syndrome

Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs.

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Spermidine is a polyamine compound found in ribosomes and living tissues, and having various metabolic functions within organisms.

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Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells.

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Spore photoproduct lyase

Spore photoproduct lyase (SAM, SP lyase, SPL, SplB, SplG) is a radical SAM enzyme that repairs a particular kind of lesion that arises upon UV-radiation of bacterial DNA.

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Tramadol, sold under the brand name Ultram among others, is an opioid pain medication used to treat moderate to moderately severe pain.

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Transfer RNA

A transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length, that serves as the physical link between the mRNA and the amino acid sequence of proteins.

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Transsulfuration pathway

The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine, through the intermediate cystathionine.

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United States

The United States of America (USA), commonly known as the United States (U.S.) or America, is a federal republic composed of 50 states, a federal district, five major self-governing territories, and various possessions.

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Redirects here:

ATC code A16AA02, ATCvet code QA16AA02, Ademetionine, Adomet, C15H22N6O5S, C15H22N6O5S+, EC, Radical-SAM, S-Adenosyl-L-methionine, S-Adenosylmethionine, S-adenosyl methionine, S-adenosyl-L-methionine, S-adenosyl-l-methionine, S-adenosyl-methionine, S-adenosylmethione, S-adenosylmethionine, SAM cofactor, SAM-e, SAMe, SAMe Rx-Mood, Sam-Sulfate, Sam-e, Same-E.


[1] https://en.wikipedia.org/wiki/S-Adenosyl_methionine

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