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34 relations: Addiction Biology, Agonist, Alpha-2A adrenergic receptor, Attention deficit hyperactivity disorder, Bioavailability, Biological half-life, Biotransformation, Blood pressure, Central nervous system, CYP3A4, CYP3A5, Diastole, Epoxide, Ethanol, First pass effect, Guanabenz, Hypertension, Intravenous therapy, Kidney, Metabolite, Modified-release dosage, Nicotine, Opioid, Pediatrics, Peripheral nervous system, Posttraumatic stress disorder, Prefrontal cortex, Sympathetic nervous system, Sympatholytic, Systole, Tourette syndrome, Valvular heart disease, Xylazine, 5-HT2B receptor.
Addiction Biology
Addiction Biology is a peer-reviewed medical journal covering research on substance abuse.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Alpha-2A adrenergic receptor
The alpha-2A adrenergic receptor (α2A adrenoceptor), also known as ADRA2A, is an α2 adrenergic receptor, and also denotes the human gene encoding it.
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Attention deficit hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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Biotransformation
Biotransformation is the chemical modification (or modifications) made by an organism on a chemical compound.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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CYP3A5
Cytochrome P450 3A5 is a protein that in humans is encoded by the CYP3A5 gene.
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Diastole
Diastole is the part of the cardiac cycle during which the heart refills with blood after the emptying done during systole (contraction).
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Epoxide
An epoxide is a cyclic ether with a three-atom ring.
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Ethanol
Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.
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First pass effect
The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.
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Guanabenz
Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 adrenergic receptor that is used as an antihypertensive drug.
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Hypertension
Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.
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Intravenous therapy
Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Metabolite
A metabolite is the intermediate end product of metabolism.
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Modified-release dosage
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release dosage) or to a specific target in the body (targeted-release dosage).
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Nicotine
Nicotine is a potent parasympathomimetic stimulant and an alkaloid found in the nightshade family of plants.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Pediatrics
Pediatrics (also spelled paediatrics or pædiatrics) is the branch of medicine that involves the medical care of infants, children, and adolescents.
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Peripheral nervous system
The peripheral nervous system (PNS) is one of the two components of the nervous system, the other part is the central nervous system (CNS).
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Posttraumatic stress disorder
Posttraumatic stress disorder (PTSD)Acceptable variants of this term exist; see the Terminology section in this article.
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Prefrontal cortex
In mammalian brain anatomy, the prefrontal cortex (PFC) is the cerebral cortex which covers the front part of the frontal lobe.
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Sympathetic nervous system
The sympathetic nervous system (SNS) is one of the two main divisions of the autonomic nervous system, the other being the parasympathetic nervous system.
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Sympatholytic
A sympatholytic (or sympathoplegic) drug is a medication that opposes the downstream effects of postganglionic nerve firing in effector organs innervated by the sympathetic nervous system (SNS).
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Systole
The systole is that part of the cardiac cycle during which some chambers of the heart muscle contract after refilling with blood.
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Tourette syndrome
Tourette syndrome (TS or simply Tourette's) is a common neuropsychiatric disorder with onset in childhood, characterized by multiple motor tics and at least one vocal (phonic) tic.
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Valvular heart disease
Valvular heart disease is any disease process involving one or more of the four valves of the heart (the aortic and bicuspid valves on the left side of heart and the pulmonary and tricuspid valves on the right side of heart. These conditions occur largely as a consequence of aging,Burden of valvular heart diseases: a population-based study. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano. Lancet. 2006 Sep;368(9540):1005-11. but may also be the result of congenital (inborn) abnormalities or specific disease or physiologic processes including rheumatic heart disease and pregnancy. Anatomically, the valves are part of the dense connective tissue of the heart known as the cardiac skeleton and are responsible for the regulation of blood flow through the heart and great vessels. Valve failure or dysfunction can result in diminished heart functionality, though the particular consequences are dependent on the type and severity of valvular disease. Treatment of damaged valves may involve medication alone, but often involves surgical valve repair (valvuloplasty) or replacement (insertion of an artificial heart valve).
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Xylazine
Xylazine is an analogue of clonidine and an agonist at the α2 class of adrenergic receptor.
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5-HT2B receptor
5-Hydroxytryptamine receptor 2B (5-HT2B) also known as serotonin receptor 2B is a protein that in humans is encoded by the HTR2B gene.
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Redirects here:
ATC code C02AC02, ATCvet code QC02AC02, C9H9Cl2N3O, Estulic, Guanfacine hydrochloride, Intuniv, Tenex (drug).
References
[1] https://en.wikipedia.org/wiki/Guanfacine
