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30 relations: Afimoxifene, Agonist, Antigonadotropin, Breast cancer, Cardiovascular disease, Clinical trial, DNA adduct, Endoxifen, Estrogen, Estrogen receptor, Follicle-stimulating hormone, Germany, International nonproprietary name, Japan, Ligand (biochemistry), Liver, Liver tumor, Luteinizing hormone, Menopause, Nonsteroidal, Oral administration, Osteoporosis, Phases of clinical research, Selective estrogen receptor modulator, Sex hormone-binding globulin, Structural analog, Tamoxifen, Triphenylethylene, United States Adopted Name, Uterus.
Afimoxifene
Afimoxifene, also known as 4-hydroxytamoxifen (4-OHT, 4-HT, OHTAM, others), is a selective estrogen receptor modulator (SERM) of the triphenylethylene group and the major active metabolite of tamoxifen.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Antigonadotropin
An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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Cardiovascular disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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DNA adduct
In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical.
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Endoxifen
Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is an orally active nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that is or was under development for the treatment of estrogen receptor-positive breast cancer.
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Estrogen
Estrogen, or oestrogen, is the primary female sex hormone.
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Estrogen receptor
Estrogen receptors (ERs) are a group of proteins found inside cells.
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Follicle-stimulating hormone
Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone.
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Germany
Germany (Deutschland), officially the Federal Republic of Germany (Bundesrepublik Deutschland), is a sovereign state in central-western Europe.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Japan
Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.
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Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Liver tumor
Liver tumors or hepatic tumors are tumors or growths on or in the liver (medical terms pertaining to the liver often start in hepato- or hepatic from the Greek word for liver, hepar).
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Luteinizing hormone
Luteinizing hormone (LH, also known as lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland.
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Menopause
Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.
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Nonsteroidal
Nonsteroidal is a term which is used to describe a compound that is not a steroid.
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Oral administration
| name.
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Osteoporosis
Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.
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Phases of clinical research
The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for a process which would be useful as a medical treatment.
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Selective estrogen receptor modulator
Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).
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Sex hormone-binding globulin
Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to the two sex hormones: androgen and estrogen.
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Structural analog
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
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Tamoxifen
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.
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Triphenylethylene
Triphenylethylene (TPE) is a simple aromatic hydrocarbon that possesses weak estrogenic activity.
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United States Adopted Name
United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.
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Uterus
The uterus (from Latin "uterus", plural uteri) or womb is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.
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Redirects here:
3-Hydroxytamoxifen, 3-hydroxytamoxifen, C26H29NO2, Droloxifen, FK 435, FK-435, FK435, ICI 79,280, ICI 79280, ICI-79,280, ICI-79280, ICI79,280, ICI79280, K 060, K 21060E, K-060, K-21060E, K060, K21060E, RP 60,850, RP 60850, RP-60,850, RP-60850, RP60,850, RP60850.
References
[1] https://en.wikipedia.org/wiki/Droloxifene
