Get it on Google Play
New! Download Unionpedia on your Android™ device!
Faster access than browser!


Index Droloxifene

Droloxifene (INN, USAN) (former developmental code names FK-435, ICI-79280, K-060, K-21060E, RP-60850), also known as 3-hydroxytamoxifen, is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that was developed originally in Germany and later in Japan for the treatment of breast cancer, osteoporosis in men and postmenopausal women, and cardiovascular disorders but was abandoned and never marketed. [1]

30 relations: Afimoxifene, Agonist, Antigonadotropin, Breast cancer, Cardiovascular disease, Clinical trial, DNA adduct, Endoxifen, Estrogen, Estrogen receptor, Follicle-stimulating hormone, Germany, International nonproprietary name, Japan, Ligand (biochemistry), Liver, Liver tumor, Luteinizing hormone, Menopause, Nonsteroidal, Oral administration, Osteoporosis, Phases of clinical research, Selective estrogen receptor modulator, Sex hormone-binding globulin, Structural analog, Tamoxifen, Triphenylethylene, United States Adopted Name, Uterus.


Afimoxifene, also known as 4-hydroxytamoxifen (4-OHT, 4-HT, OHTAM, others), is a selective estrogen receptor modulator (SERM) of the triphenylethylene group and the major active metabolite of tamoxifen.

New!!: Droloxifene and Afimoxifene · See more »


An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

New!!: Droloxifene and Agonist · See more »


An antigonadotropin is a drug which suppresses the activity and/or downstream effects of one or both of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

New!!: Droloxifene and Antigonadotropin · See more »

Breast cancer

Breast cancer is cancer that develops from breast tissue.

New!!: Droloxifene and Breast cancer · See more »

Cardiovascular disease

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.

New!!: Droloxifene and Cardiovascular disease · See more »

Clinical trial

Clinical trials are experiments or observations done in clinical research.

New!!: Droloxifene and Clinical trial · See more »

DNA adduct

In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical.

New!!: Droloxifene and DNA adduct · See more »


Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is an orally active nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that is or was under development for the treatment of estrogen receptor-positive breast cancer.

New!!: Droloxifene and Endoxifen · See more »


Estrogen, or oestrogen, is the primary female sex hormone.

New!!: Droloxifene and Estrogen · See more »

Estrogen receptor

Estrogen receptors (ERs) are a group of proteins found inside cells.

New!!: Droloxifene and Estrogen receptor · See more »

Follicle-stimulating hormone

Follicle-stimulating hormone (FSH) is a gonadotropin, a glycoprotein polypeptide hormone.

New!!: Droloxifene and Follicle-stimulating hormone · See more »


Germany (Deutschland), officially the Federal Republic of Germany (Bundesrepublik Deutschland), is a sovereign state in central-western Europe.

New!!: Droloxifene and Germany · See more »

International nonproprietary name

The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.

New!!: Droloxifene and International nonproprietary name · See more »


Japan (日本; Nippon or Nihon; formally 日本国 or Nihon-koku, lit. "State of Japan") is a sovereign island country in East Asia.

New!!: Droloxifene and Japan · See more »

Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

New!!: Droloxifene and Ligand (biochemistry) · See more »


The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

New!!: Droloxifene and Liver · See more »

Liver tumor

Liver tumors or hepatic tumors are tumors or growths on or in the liver (medical terms pertaining to the liver often start in hepato- or hepatic from the Greek word for liver, hepar).

New!!: Droloxifene and Liver tumor · See more »

Luteinizing hormone

Luteinizing hormone (LH, also known as lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland.

New!!: Droloxifene and Luteinizing hormone · See more »


Menopause, also known as the climacteric, is the time in most women's lives when menstrual periods stop permanently, and they are no longer able to bear children.

New!!: Droloxifene and Menopause · See more »


Nonsteroidal is a term which is used to describe a compound that is not a steroid.

New!!: Droloxifene and Nonsteroidal · See more »

Oral administration

| name.

New!!: Droloxifene and Oral administration · See more »


Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.

New!!: Droloxifene and Osteoporosis · See more »

Phases of clinical research

The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for a process which would be useful as a medical treatment.

New!!: Droloxifene and Phases of clinical research · See more »

Selective estrogen receptor modulator

Selective estrogen receptor modulators (SERMs) are a class of drugs that act on the estrogen receptor (ER).

New!!: Droloxifene and Selective estrogen receptor modulator · See more »

Sex hormone-binding globulin

Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to the two sex hormones: androgen and estrogen.

New!!: Droloxifene and Sex hormone-binding globulin · See more »

Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

New!!: Droloxifene and Structural analog · See more »


Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.

New!!: Droloxifene and Tamoxifen · See more »


Triphenylethylene (TPE) is a simple aromatic hydrocarbon that possesses weak estrogenic activity.

New!!: Droloxifene and Triphenylethylene · See more »

United States Adopted Name

United States Adopted Names are unique nonproprietary names assigned to pharmaceuticals marketed in the United States.

New!!: Droloxifene and United States Adopted Name · See more »


The uterus (from Latin "uterus", plural uteri) or womb is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.

New!!: Droloxifene and Uterus · See more »

Redirects here:

3-Hydroxytamoxifen, 3-hydroxytamoxifen, C26H29NO2, Droloxifen, FK 435, FK-435, FK435, ICI 79,280, ICI 79280, ICI-79,280, ICI-79280, ICI79,280, ICI79280, K 060, K 21060E, K-060, K-21060E, K060, K21060E, RP 60,850, RP 60850, RP-60,850, RP-60850, RP60,850, RP60850.


[1] https://en.wikipedia.org/wiki/Droloxifene

Hey! We are on Facebook now! »