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Goodpasture syndrome

Index Goodpasture syndrome

Goodpasture syndrome (GPS) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure. [1]

51 relations: Antibody, Australia, Autoimmune disease, Azathioprine, Bacteremia, Basement membrane, Biopsy, Blood plasma, C-ANCA, Centrifuge, Chloroform, Cocaine, Corticosteroid, Cyclophosphamide, Edema, Epitope, Ernest William Goodpasture, Glomerular basement membrane, Glomerulus, Hematuria, Hemoptysis, HLA-DR15, Hypertension, Immunosuppressive drug, Influenza A virus, Kidney failure, Māori people, Micrograph, Monoclonal antibody, New Zealand, Periodic acid–Schiff stain, Plasma cell, Plasmapheresis, Platelet, Prednisone, Proteinuria, Pulmonary alveolus, Pulmonary-renal syndrome, Rapidly progressive glomerulonephritis, Rare disease, Red blood cell, Rituximab, Sepsis, Shortness of breath, T cell, The International League of Dermatological Societies, Tobacco, Type IV collagen, Uremia, Vanderbilt University, ..., White blood cell. Expand index (1 more) »

Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Australia

Australia, officially the Commonwealth of Australia, is a sovereign country comprising the mainland of the Australian continent, the island of Tasmania and numerous smaller islands.

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Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.

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Azathioprine

Azathioprine (AZA), sold under the brand name Imuran among others, is an immunosuppressive medication.

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Bacteremia

Bacteremia (also bacteraemia) is the presence of bacteria in the blood.

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Basement membrane

The basement membrane is a thin, fibrous, extracellular matrix of tissue that separates the lining of an internal or external body surface from underlying connective tissue in metazoans.

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Biopsy

A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease.

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Blood plasma

Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension; this makes plasma the extracellular matrix of blood cells.

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C-ANCA

c-ANCAs, or PR3-ANCA, or Cytoplasmic antineutrophil cytoplasmic antibodies, are a type of autoantibody, an antibody produced by the body that acts against one of its own proteins.

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Centrifuge

A centrifuge is a piece of equipment that puts an object in rotation around a fixed axis (spins it in a circle), applying a force perpendicular to the axis of spin (outward) that can be very strong.

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Chloroform

Chloroform, or trichloromethane, is an organic compound with formula CHCl3.

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Cocaine

Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.

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Corticosteroid

Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones.

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Cyclophosphamide

Cyclophosphamide (CP), also known as cytophosphane among other, is a medication used as chemotherapy and to suppress the immune system.

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Edema

Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.

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Epitope

An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells.

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Ernest William Goodpasture

Dr.

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Glomerular basement membrane

The glomerular basement membrane (GBM) of the kidney is the basal lamina layer of the glomerulus.

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Glomerulus

Glomerulus is a common term used in anatomy to describe globular structures of entwined vessels, fibers, or neurons.

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Hematuria

Hematuria is the presence of red blood cells in the urine.

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Hemoptysis

Hemoptysis is the coughing up of blood or blood-stained mucus from the bronchi, larynx, trachea, or lungs.

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HLA-DR15

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products.

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Hypertension

Hypertension (HTN or HT), also known as high blood pressure (HBP), is a long-term medical condition in which the blood pressure in the arteries is persistently elevated.

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Immunosuppressive drug

Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system.

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Influenza A virus

Influenza A virus causes influenza in birds and some mammals, and is the only species of influenza virus A genus of the Orthomyxoviridae family of viruses.

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Kidney failure

Kidney failure, also known as end-stage kidney disease, is a medical condition in which the kidneys no longer work.

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Māori people

The Māori are the indigenous Polynesian people of New Zealand.

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Micrograph

A micrograph or photomicrograph is a photograph or digital image taken through a microscope or similar device to show a magnified image of an item.

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Monoclonal antibody

Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.

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New Zealand

New Zealand (Aotearoa) is a sovereign island country in the southwestern Pacific Ocean.

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Periodic acid–Schiff stain

Periodic acid–Schiff (PAS) is a staining method used to detect polysaccharides such as glycogen, and mucosubstances such as glycoproteins, glycolipids and mucins in tissues.

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Plasma cell

Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete large volumes of antibodies.

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Plasmapheresis

Plasmapheresis (from the Greek πλάσμα—plasma, something molded, and ἀφαίρεσις—aphairesis, taking away) is the removal, treatment, and return or exchange of blood plasma or components thereof from and to the blood circulation.

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Platelet

Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

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Prednisone

Prednisone is a synthetic glucocorticoid drug that is mostly used to suppress the immune system.

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Proteinuria

Proteinuria is the presence of excess proteins in the urine.

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Pulmonary alveolus

A pulmonary alveolus (plural: alveoli, from Latin alveolus, "little cavity") is a hollow cavity found in the lung parenchyma, and is the basic unit of ventilation.

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Pulmonary-renal syndrome

Pulmonary-renal syndrome (PRS) is a rare medical syndrome in which respiratory failure involving bleeding in the lungs and kidney failure (glomerulonephritis) occur.

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Rapidly progressive glomerulonephritis

Rapidly progressive glomerulonephritis (RPGN) is a syndrome of the kidney that is characterized by a rapid loss of renal function, Citing: McGraw-Hill Concise Dictionary of Modern Medicine.

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Rare disease

A rare disease is any disease that affects a small percentage of the population.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Rituximab

Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer.

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Sepsis

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.

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Shortness of breath

Shortness of breath, also known as dyspnea, is the feeling that one cannot breathe well enough.

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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The International League of Dermatological Societies

The International League of Dermatological Societies (ILDS) is a non-governmental organization that works closely with the World Health Organization.

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Tobacco

Tobacco is a product prepared from the leaves of the tobacco plant by curing them.

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Type IV collagen

Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina.

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Uremia

Uremia is the condition of having "urea in the blood".

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Vanderbilt University

Vanderbilt University (informally Vandy) is a private research university in Nashville, Tennessee.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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References

[1] https://en.wikipedia.org/wiki/Goodpasture_syndrome

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