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46 relations: Angelman syndrome, Anticonvulsant, Antisense RNA, Apoptosis, Brainstem glioma, Breast cancer, Camptotheca, Camptothecin, Capsule (pharmacy), Cerebellum, Cerebral cortex, Cervical cancer, Chromosome 15, Colorectal cancer, DNA, Endometrial cancer, Ewing's sarcoma, Food and Drug Administration, GlaxoSmithKline, Hippocampus, Hydrochloride, Intercalation (biochemistry), Intravenous therapy, Kidney, Ligase, List of chemotherapeutic agents, Liver, Lung cancer, Neuroblastoma, Non-Hodgkin lymphoma, Non-small-cell lung carcinoma, Occupational therapy, Oligodendroglioma, Ovarian cancer, Paclitaxel, Physical therapy, Proteasome, Protein, Salt (chemistry), Small-cell carcinoma, Speech-language pathology, Striatum, Structural analog, Topoisomerase inhibitor, UBE3A, Ubiquitin.
Angelman syndrome
Angelman syndrome (AS) is a genetic disorder that mainly affects the nervous system.
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Anticonvulsant
Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.
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Antisense RNA
Antisense RNA (asRNA), also referred to as antisense transcript, natural antisense transcript (NAT) or antisense oligonucleotide, is a single stranded RNA that is complementary to a protein coding messenger RNA (mRNA) with which it hybridizes, and thereby blocks its translation into protein.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Brainstem glioma
A brainstem glioma is a cancerous glioma tumor in the brainstem.
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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Camptotheca
Camptotheca (happy tree, cancer tree, or tree of life) is a genus of medium-sized deciduous trees growing to tall, native to southern China and Tibet.
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Camptothecin
Camptothecin (CPT) is a topoisomerase inhibitor.
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Capsule (pharmacy)
In the manufacture of pharmaceuticals, encapsulation refers to a range of dosage forms—techniques used to enclose medicines—in a relatively stable shell known as a capsule, allowing them to, for example, be taken orally or be used as suppositories.
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Cerebellum
The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates.
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Cerebral cortex
The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.
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Cervical cancer
Cervical cancer is a cancer arising from the cervix.
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Chromosome 15
Chromosome 15 is one of the 23 pairs of chromosomes in humans.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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Endometrial cancer
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).
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Ewing's sarcoma
Ewing's sarcoma or Ewing sarcoma is a malignant small, round, blue cell tumor.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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GlaxoSmithKline
GlaxoSmithKline plc (GSK) is a British pharmaceutical company headquartered in Brentford, London.
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Hippocampus
The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.
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Hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine).
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Intercalation (biochemistry)
In biochemistry, intercalation is the insertion of molecules between the planar bases of deoxyribonucleic acid (DNA).
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Intravenous therapy
Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Ligase
In biochemistry, a ligase is an enzyme that can catalyze the joining of two large molecules by forming a new chemical bond, usually with accompanying hydrolysis of a small pendant chemical group on one of the larger molecules or the enzyme catalyzing the linking together of two compounds, e.g., enzymes that catalyze joining of C-O, C-S, C-N, etc.
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List of chemotherapeutic agents
This is a list of chemotherapeutic agents (also known as cytotoxic agents) that are known to be of use in chemotherapy for cancer.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
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Neuroblastoma
Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands, but can also develop in the neck, chest, abdomen, or spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Occasionally, neuroblastoma may be due to a mutation inherited from a person's parents. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like. Treatment and outcomes depends on the risk group a person is in. Treatments may include observation, surgery, radiation, chemotherapy, or stem cell transplantation. Low-risk disease in babies typically has a good outcome with surgery or simply observation. In high-risk disease, chances of long-term survival, however, are less than 40% despite aggressive treatment. Neuroblastoma is the most common cancer in babies and the third-most common cancer in children after leukemia and brain cancer. About one in every 7,000 children is affected at some time. About 90% of cases occur in children less than 5 years old and it is rare in adults. Of cancer deaths in children, about 15% are due to neuroblastoma. The disease was first described in the 1800s.
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Non-Hodgkin lymphoma
Non-Hodgkin lymphoma (NHL) is a group of blood cancers that includes all types of lymphoma except Hodgkin's lymphomas.
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Non-small-cell lung carcinoma
Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).
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Occupational therapy
Occupational therapy (OT) is the use of assessment and intervention to develop, recover, or maintain the meaningful activities, or occupations, of individuals, groups, or communities.
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Oligodendroglioma
Oligodendrogliomas are a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell.
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Ovarian cancer
Ovarian cancer is a cancer that forms in or on an ovary.
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Paclitaxel
Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer.
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Physical therapy
Physical therapy (PT), also known as physiotherapy, is one of the allied health professions that, by using mechanical force and movements (bio-mechanics or kinesiology), manual therapy, exercise therapy, and electrotherapy, remediates impairments and promotes mobility and function.
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Proteasome
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Salt (chemistry)
In chemistry, a salt is an ionic compound that can be formed by the neutralization reaction of an acid and a base.
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Small-cell carcinoma
Small-cell carcinoma (also known as "small-cell lung cancer", or "oat-cell carcinoma") is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract.
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Speech-language pathology
Speech-language pathology is a field of expertise practiced by a clinician known as a speech-language pathologist (SLP), also sometimes referred to as a speech and language therapist or a speech therapist. SLP is considered a "related health profession" along with audiology, optometry, occupational therapy, clinical psychology, physical therapy, and others.
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Striatum
The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.
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Structural analog
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
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Topoisomerase inhibitor
Topoisomerase inhibitors are chemical compounds that block the action of topoisomerase (topoisomerase I and II), which is a type of enzyme that controls the changes in DNA structure by catalyzing the breaking and rejoining of the phosphodiester backbone of DNA strands during the normal cell cycle.
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UBE3A
Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene.
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Ubiquitin
Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.
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Redirects here:
ATC code L01XX17, ATCvet code QL01XX17, C23H23N3O5, Hycamptamine, Hycamptin, Hycamtin, Topotecan Hydrochloride, Topotecan hydrochloride.
References
[1] https://en.wikipedia.org/wiki/Topotecan
