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Ornithine decarboxylase

Index Ornithine decarboxylase

The enzyme ornithine decarboxylase (ODC) catalyzes the decarboxylation of ornithine (a product of the urea cycle) to form putrescine. [1]

Table of Contents

  1. 55 relations: Active site, Alpha beta barrel, Amino acid, Androgen, Antioxidant, Apoptosis, Asbestos, Beta sheet, C-terminus, Cancer, Carcinogenesis, Cell division, Cofactor (biochemistry), Committed step, De novo mutation, Decarboxylation, DNA, Drosophila, Eflornithine, Gap junction, Giardia, Isomer, Lysine, Monomer, Myc, MYC, Negative feedback, Oncogene, Ornithine, Ornithine decarboxylase antizyme, P21, Parasitism, Paucilactobacillus wasatchensis, Plasmodium, Polyamine, Prostate, Proteasome, Protein dimer, Putrescine, Pyridoxal phosphate, Quinoid, Regulatory T cell, Schiff base, Seizure, Solanaceae, Spermidine, Spermidine synthase, Spermine, T helper 17 cell, T helper cell, ... Expand index (5 more) »

Active site

In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction.

See Ornithine decarboxylase and Active site

Alpha beta barrel

An alpha/beta barrel is a protein fold formed by units composed of a short α-helix followed by two anti-parallel β-strands, followed by an α-helix and a β-strand; the three β-strands form a β-sheet that runs parallel to the barrel and the α-helix is in the outside of the barrel but does not contact the α-helices of the other repeats like in TIM barrels.

See Ornithine decarboxylase and Alpha beta barrel

Amino acid

Amino acids are organic compounds that contain both amino and carboxylic acid functional groups.

See Ornithine decarboxylase and Amino acid

Androgen

An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

See Ornithine decarboxylase and Androgen

Antioxidant

Antioxidants are compounds that inhibit oxidation (usually occurring as autoxidation), a chemical reaction that can produce free radicals.

See Ornithine decarboxylase and Antioxidant

Apoptosis

Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.

See Ornithine decarboxylase and Apoptosis

Asbestos

Asbestos is a naturally occurring fibrous silicate mineral.

See Ornithine decarboxylase and Asbestos

Beta sheet

The beta sheet (β-sheet, also β-pleated sheet) is a common motif of the regular protein secondary structure.

See Ornithine decarboxylase and Beta sheet

C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

See Ornithine decarboxylase and C-terminus

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

See Ornithine decarboxylase and Cancer

Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

See Ornithine decarboxylase and Carcinogenesis

Cell division

Cell division is the process by which a parent cell divides into two daughter cells.

See Ornithine decarboxylase and Cell division

Cofactor (biochemistry)

A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases the rate of a chemical reaction).

See Ornithine decarboxylase and Cofactor (biochemistry)

Committed step

In enzymology, the committed step (also known as the first committed step) is an effectively irreversible enzymatic reaction that occurs at a branch point during the biosynthesis of some molecules.

See Ornithine decarboxylase and Committed step

De novo mutation

A de novo mutation (DNM) is any mutation or alteration in the genome of an individual organism (human, animal, plant, microbe, etc.) that was not inherited from its parents.

See Ornithine decarboxylase and De novo mutation

Decarboxylation

Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2).

See Ornithine decarboxylase and Decarboxylation

DNA

Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.

See Ornithine decarboxylase and DNA

Drosophila

Drosophila is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.

See Ornithine decarboxylase and Drosophila

Eflornithine

Eflornithine, sold under the brand name Vaniqa among others, is a medication used to treat African trypanosomiasis (sleeping sickness) and excessive hair growth on the face in women.

See Ornithine decarboxylase and Eflornithine

Gap junction

Gap junctions are membrane channels between cells that allow the exchange of substances from the cytoplasm of one cell directly to the cytoplasm of an adjacent cell.

See Ornithine decarboxylase and Gap junction

Giardia

Giardia is a genus of anaerobic flagellated protozoan parasites of the phylum Metamonada that colonise and reproduce in the small intestines of several vertebrates, causing the disease giardiasis.

See Ornithine decarboxylase and Giardia

Isomer

In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element – but distinct arrangements of atoms in space.

See Ornithine decarboxylase and Isomer

Lysine

Lysine (symbol Lys or K) is an α-amino acid that is a precursor to many proteins.

See Ornithine decarboxylase and Lysine

Monomer

A monomer (mono-, "one" + -mer, "part") is a molecule that can react together with other monomer molecules to form a larger polymer chain or three-dimensional network in a process called polymerization.

See Ornithine decarboxylase and Monomer

Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. Ornithine decarboxylase and Myc are genes on human chromosome 2.

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MYC

MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the myc family of transcription factors.

See Ornithine decarboxylase and MYC

Negative feedback

Negative feedback (or balancing feedback) occurs when some function of the output of a system, process, or mechanism is fed back in a manner that tends to reduce the fluctuations in the output, whether caused by changes in the input or by other disturbances.

See Ornithine decarboxylase and Negative feedback

Oncogene

An oncogene is a gene that has the potential to cause cancer.

See Ornithine decarboxylase and Oncogene

Ornithine

Ornithine is a non-proteinogenic α-amino acid that plays a role in the urea cycle.

See Ornithine decarboxylase and Ornithine

Ornithine decarboxylase antizyme

In molecular biology, Ornithine decarboxylase antizyme (ODC-AZ) is an ornithine decarboxylase inhibitor. Ornithine decarboxylase and ornithine decarboxylase antizyme are eC 4.1.1.

See Ornithine decarboxylase and Ornithine decarboxylase antizyme

P21

p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2.

See Ornithine decarboxylase and P21

Parasitism

Parasitism is a close relationship between species, where one organism, the parasite, lives on or inside another organism, the host, causing it some harm, and is adapted structurally to this way of life.

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Paucilactobacillus wasatchensis

Paucilactobacillus wasatchensis is a species of heterofermentative lactic acid bacteria (LAB).

See Ornithine decarboxylase and Paucilactobacillus wasatchensis

Plasmodium

Plasmodium is a genus of unicellular eukaryotes that are obligate parasites of vertebrates and insects.

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Polyamine

A polyamine is an organic compound having more than two amino groups.

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Prostate

The prostate is both an accessory gland of the male reproductive system and a muscle-driven mechanical switch between urination and ejaculation.

See Ornithine decarboxylase and Prostate

Proteasome

Proteasomes are protein complexes which degrade ubiquitin-tagged proteins by proteolysis, a chemical reaction that breaks peptide bonds.

See Ornithine decarboxylase and Proteasome

Protein dimer

In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently bound.

See Ornithine decarboxylase and Protein dimer

Putrescine

Putrescine is an organic compound with the formula (CH2)4(NH2)2.

See Ornithine decarboxylase and Putrescine

Pyridoxal phosphate

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions.

See Ornithine decarboxylase and Pyridoxal phosphate

Quinoid

In organic chemistry, quinoids are a class of chemical compounds that are derived from quinone.

See Ornithine decarboxylase and Quinoid

Regulatory T cell

The regulatory T cells (Tregs or Treg cells), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease.

See Ornithine decarboxylase and Regulatory T cell

Schiff base

In organic chemistry, a Schiff base (named after Hugo Schiff) is a compound with the general structure (.

See Ornithine decarboxylase and Schiff base

Seizure

A seizure is a period of symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

See Ornithine decarboxylase and Seizure

Solanaceae

The Solanaceae, or the nightshades, are a family of flowering plants that ranges from annual and perennial herbs to vines, lianas, epiphytes, shrubs, and trees, and includes a number of agricultural crops, medicinal plants, spices, weeds, and ornamentals.

See Ornithine decarboxylase and Solanaceae

Spermidine

Spermidine is a polyamine compound found in ribosomes and living tissues and having various metabolic functions within organisms.

See Ornithine decarboxylase and Spermidine

Spermidine synthase

Spermidine synthase is an enzyme that catalyzes the transfer of the propylamine group from ''S''-adenosylmethioninamine to putrescine in the biosynthesis of spermidine.

See Ornithine decarboxylase and Spermidine synthase

Spermine

Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells.

See Ornithine decarboxylase and Spermine

T helper 17 cell

T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17).

See Ornithine decarboxylase and T helper 17 cell

T helper cell

The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system.

See Ornithine decarboxylase and T helper cell

Tight junction

Tight junctions, also known as occluding junctions or zonulae occludentes (singular, zonula occludens), are multiprotein junctional complexes whose canonical function is to prevent leakage of solutes and water and seals between the epithelial cells.

See Ornithine decarboxylase and Tight junction

Trypanosoma

Trypanosoma is a genus of kinetoplastids (class Trypanosomatidae), a monophyletic group of unicellular parasitic flagellate protozoa.

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Ubiquitin

Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''.

See Ornithine decarboxylase and Ubiquitin

Ultraviolet

Ultraviolet (UV) light is electromagnetic radiation of wavelengths of 10–400 nanometers, shorter than that of visible light, but longer than X-rays.

See Ornithine decarboxylase and Ultraviolet

Urea cycle

The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions that produces urea (NH2)2CO from ammonia (NH3).

See Ornithine decarboxylase and Urea cycle

References

[1] https://en.wikipedia.org/wiki/Ornithine_decarboxylase

Also known as EC 4.1.1.17, L-ornithine carboxy-lyase (putrescine-forming), ODC1, ODC1 (gene).

, Tight junction, Trypanosoma, Ubiquitin, Ultraviolet, Urea cycle.