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Index Helicase

Helicases are a class of enzymes vital to all living organisms. [1]

118 relations: Adenosine triphosphate, Alpha-thalassemia mental retardation syndrome, Alzheimer's disease, Amino acid, Amyotrophic lateral sclerosis, Arabidopsis thaliana, ASCC3, ATRX, Base pair, Biomolecular structure, Bloom syndrome, Bloom syndrome protein, Boltzmann constant, BRIP1, CHD1, CHD1L, CHD2, CHD3, CHD4, CHD5, CHD7, CHD8, CHD9, Chromatid, Chromodomain, Chromosomal crossover, Cockayne syndrome, Conserved sequence, Cytosine, D-loop, DDX10, DDX11, DDX3X, DDX5, DDX6, DEAD box, DEAD/DEAH box helicase, Directionality (molecular biology), DNA, DNA damage (naturally occurring), DNA repair, DNA replication, DNA², DnaB helicase, Enzyme, ERCC2, FANCM, Förster resonance energy transfer, Genetic recombination, Gram-negative bacteria, ..., Gram-positive bacteria, Guanine, Helicase, HELLS, Heterochromatin protein 1, HFM1, HLTF, Homologous recombination, Human genome, Hydrogen bond, Hydrolysis, In vitro, In vivo, Lethal congenital contracture syndrome, LGP2, MDA5, Meiosis, Minichromosome maintenance, Monomer, Motor protein, Natural selection, NAV2, Nucleic acid, Nucleic acid double helix, Nucleotide excision repair, Oligomer, Organism, PerkinElmer, Phosphodiester bond, Poikiloderma, Polyacrylamide gel electrophoresis, Processivity, Protein dimer, Radioactive tracer, RecQ helicase, RECQL, RECQL4, Rho factor, Ribosome, Ribosome biogenesis, RIG-I, RNA, RNA editing, RNA Helicase A, RNA splicing, Rothmund–Thomson syndrome, Schizosaccharomyces pombe, Scintillation proximity assay, Sequence homology, Sequence motif, SHPRH, Sister chromatids, SMARCA4, SMARCAL1, Spinal muscular atrophy, Spinocerebellar ataxia, Substrate (chemistry), Synthesis-dependent strand annealing, Transcription (biology), Transcription factor II H, Translation, Translation (biology), Trichothiodystrophy, UvrABC endonuclease, Werner syndrome, Werner syndrome helicase, WRNIP1, Xeroderma pigmentosum. Expand index (68 more) »

Adenosine triphosphate

Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.

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Alpha-thalassemia mental retardation syndrome

Alpha-thalassemia mental retardation syndrome (ATRX), also called alpha-thalassemia X-linked mental retardation, nondeletion type or ATR-X syndrome, is a condition caused by a mutated gene.

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Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND), and Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.

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Arabidopsis thaliana

Arabidopsis thaliana, the thale cress, mouse-ear cress or arabidopsis, is a small flowering plant native to Eurasia and Africa.

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Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.

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Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene.

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Base pair

A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.

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Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

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Bloom syndrome

Bloom syndrome (often abbreviated as BS in literature), also known as Bloom-Torre-Machacek syndrome, is a rare autosomal recessive disorder characterized by short stature, predisposition to the development of cancer and genomic instability.

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Bloom syndrome protein

Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome.

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Boltzmann constant

The Boltzmann constant, which is named after Ludwig Boltzmann, is a physical constant relating the average kinetic energy of particles in a gas with the temperature of the gas.

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Fanconi anemia group J protein is a protein that in humans is encoded by the BRCA1-interacting protein 1 (BRIP1) gene.

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Chromodomain-helicase-DNA-binding protein 1 is an enzyme that in humans is encoded by the CHD1 gene.

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Chromodomain-helicase-DNA-binding protein 1-like (ALC1) is an enzyme that in humans is encoded by the CHD1L gene.

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Chromodomain-helicase-DNA-binding protein 2 is an enzyme that in humans is encoded by the CHD2 gene.

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Chromodomain-helicase-DNA-binding protein 3 is an enzyme that in humans is encoded by the CHD3 gene.

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Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene.

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Chromodomain-helicase-DNA-binding protein 5 is an enzyme that in humans is encoded by the CHD5 gene.

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Chromodomain-helicase-DNA-binding protein 7 also known as ATP-dependent helicase CHD7 is an enzyme that in humans is encoded by the CHD7 gene.

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Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene.

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Chromodomain-helicase-DNA-binding protein 9 is an enzyme that in humans is encoded by the CHD9 gene.

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A chromatid (Greek khrōmat- 'color' + -id) is one copy of a newly copied chromosome which is still joined to the original chromosome by a single centromere.

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A chromodomain (chromatin organization modifier) is a protein structural domain of about 40–50 amino acid residues commonly found in proteins associated with the remodeling and manipulation of chromatin.

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Chromosomal crossover

Chromosomal crossover (or crossing over) is the exchange of genetic material between homologous chromosomes that results in recombinant chromosomes during sexual reproduction.

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Cockayne syndrome

Cockayne syndrome (CS), also called Neill-Dingwall syndrome, is a rare and fatal autosomal recessive neurodegenerative disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), eye disorders and premature aging.

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Conserved sequence

In evolutionary biology, conserved sequences are similar or identical sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences) or within a genome (paralogous sequences).

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Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

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In molecular biology, a displacement loop or D-loop is a DNA structure where the two strands of a double-stranded DNA molecule are separated for a stretch and held apart by a third strand of DNA.

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Probable ATP-dependent RNA helicase DDX10 is an enzyme that in humans is encoded by the DDX10 gene.

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Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.

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ATP-dependent RNA helicase DDX3X is an enzyme that in humans is encoded by the DDX3X gene.

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Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.

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Probable ATP-dependent RNA helicase DDX6 is an enzyme that in humans is encoded by the DDX6 gene.

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DEAD box

DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids.

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DEAD/DEAH box helicase

The DEAD/DEAH box helicases are a family of proteins whose purpose is to unwind nucleic acids.

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Directionality (molecular biology)

Directionality, in molecular biology and biochemistry, is the end-to-end chemical orientation of a single strand of nucleic acid.

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Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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DNA damage (naturally occurring)

DNA damage is distinctly different from mutation, although both are types of error in DNA.

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

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DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

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is a science fiction manga series written and illustrated by Masakazu Katsura.

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DnaB helicase

DnaB helicase is an enzyme in bacteria which opens the replication fork during DNA replication.

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Enzymes are macromolecular biological catalysts.

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ERCC2, or XPD is a protein involved in transcription-coupled nucleotide excision repair.

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Fanconi anemia, complementation group M, also known as FANCM is a human gene.

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Förster resonance energy transfer

Förster resonance energy transfer (FRET), fluorescence resonance energy transfer (FRET), resonance energy transfer (RET) or electronic energy transfer (EET) is a mechanism describing energy transfer between two light-sensitive molecules (chromophores).

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Genetic recombination

Genetic recombination (aka genetic reshuffling) is the production of offspring with combinations of traits that differ from those found in either parent.

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Gram-negative bacteria

Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the gram-staining method of bacterial differentiation.

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Gram-positive bacteria

Gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their cell wall.

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Guanine (or G, Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA).

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Helicases are a class of enzymes vital to all living organisms.

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Lymphoid-specific helicase is an enzyme that in humans is encoded by the HELLS gene.

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Heterochromatin protein 1

The family of heterochromatin protein 1 (HP1) ("Chromobox Homolog", CBX) consists of highly conserved proteins, which have important functions in the cell nucleus.

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HFM1 is a gene that in humans encodes a protein necessary for homologous recombination of chromosomes.

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Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene.

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Homologous recombination

Homologous recombination is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical molecules of DNA.

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Human genome

The human genome is the complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria.

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Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

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Hydrolysis is a term used for both an electro-chemical process and a biological one.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

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Lethal congenital contracture syndrome

Lethal congenital contracture syndrome 1 (LCCS1), also called Multiple contracture syndrome, Finnish type, is an autosomal recessive genetic disorder characterized by total immobility of a fetus, detectable at around the 13th week of pregnancy.

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Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the DHX58 gene.

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MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene.

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Meiosis (from Greek μείωσις, meiosis, which means lessening) is a specialized type of cell division that reduces the chromosome number by half, creating four haploid cells, each genetically distinct from the parent cell that gave rise to them.

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Minichromosome maintenance

The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication.

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A monomer (mono-, "one" + -mer, "part") is a molecule that "can undergo polymerization thereby contributing constitutional units to the essential structure of a macromolecule".

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Motor protein

Motor proteins are a class of molecular motors that can move along the cytoplasm of animal cells.

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Natural selection

Natural selection is the differential survival and reproduction of individuals due to differences in phenotype.

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Neuron navigator 2 is a protein that in humans is encoded by the NAV2 gene.

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Nucleic acid

Nucleic acids are biopolymers, or small biomolecules, essential to all known forms of life.

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Nucleic acid double helix

In molecular biology, the term double helix refers to the structure formed by double-stranded molecules of nucleic acids such as DNA.

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Nucleotide excision repair

Nucleotide excision repair is a DNA repair mechanism.

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An oligomer (oligo-, "a few" + -mer, "parts") is a molecular complex of chemicals that consists of a few monomer units, in contrast to a polymer, where the number of monomers is, in principle, infinite.

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In biology, an organism (from Greek: ὀργανισμός, organismos) is any individual entity that exhibits the properties of life.

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PerkinElmer, Inc., is an American multinational corporation focused in the business areas of human and environmental health, including: environmental analysis, food and consumer product safety, medical imaging, drug discovery, diagnostics, biotechnology, industrial applications, and life science research.

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Phosphodiester bond

A phosphodiester bond occurs when exactly two of the hydroxyl groups in phosphoric acid react with hydroxyl groups on other molecules to form two ester bonds.

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Poikiloderma is a skin condition that consists of areas of hypopigmentation, hyperpigmentation, telangiectasias and atrophy.

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Polyacrylamide gel electrophoresis

Polyacrylamide gel electrophoresis (PAGE) is a technique widely used in biochemistry, forensic chemistry, genetics, molecular biology and biotechnology to separate biological macromolecules, usually proteins or nucleic acids, according to their electrophoretic mobility.

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In molecular biology and biochemistry, processivity is an enzyme's ability to catalyze "consecutive reactions without releasing its substrate".

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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Radioactive tracer

A radioactive tracer, or radioactive label, is a chemical compound in which one or more atoms have been replaced by a radionuclide so by virtue of its radioactive decay it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from reactants to products.

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RecQ helicase

RecQ helicase is a family of helicase enzymes initially found in Escherichia coli that has been shown to be important in genome maintenance.

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ATP-dependent DNA helicase Q1 is an enzyme that in humans is encoded by the RECQL gene.

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ATP-dependent DNA helicase Q4 is an enzyme that in humans is encoded by the RECQL4 gene.

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Rho factor

A ρ factor (Rho factor) is a prokaryotic protein involved in the termination of transcription.

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The ribosome is a complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis (translation).

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Ribosome biogenesis

Ribosome biogenesis is the process of making ribosomes.

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RIG-I (retinoic acid-inducible gene I) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded (in humans) by the DDX58 gene.

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Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.

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RNA editing

RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase.

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RNA Helicase A

ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene.

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RNA splicing

In molecular biology, splicing is the editing of the nascent precursor messenger RNA (pre-mRNA) transcript into a mature messenger RNA (mRNA).

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Rothmund–Thomson syndrome

Rothmund–Thomson syndrome (RTS), also known as poikiloderma atrophicans with cataract or poikiloderma congenitale, is a rare autosomal recessive skin condition originally described by August von Rothmund (1830–1906) in 1868. Matthew Sydney Thomson (1894–1969) published further descriptions in 1936. There have been several reported cases associated with osteosarcoma. A hereditary genetic basis, mutations in the DNA Helicase RECQL4 gene, causing problems during initiation of DNA replication has been implicated in the syndrome.

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Schizosaccharomyces pombe

Schizosaccharomyces pombe, also called "fission yeast", is a species of yeast used in traditional brewing and as a model organism in molecular and cell biology.

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Scintillation proximity assay

Scintillation proximity assay (SPA) is an assay development and biochemical screening that permits the rapid and sensitive measurement of a broad range of biological processes in a homogeneous system.

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Sequence homology

Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.

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Sequence motif

In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.

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E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.

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Sister chromatids

A sister chromatid refers to the identical copies (chromatids) formed by the replication of a chromosome, with both copies joined together by a common centromere.

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Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 is a protein that in humans is encoded by the SMARCAL1 gene.

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Spinal muscular atrophy

Spinal muscular atrophy (SMA) is a rare neuromuscular disorder characterised by loss of motor neurons and progressive muscle wasting, often leading to early death.

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Spinocerebellar ataxia

Spinocerebellar ataxia (SCA), also known as spinocerebellar atrophy or spinocerebellar degeneration, is a progressive, degenerative, genetic disease with multiple types, each of which could be considered a disease in its own right.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Synthesis-dependent strand annealing

In genetics, the initial processes involved in repair of a double-strand break by synthesis-dependent strand annealing (SDSA) are identical to those in the double Holliday junction model, and have been most extensively studied in yeast species Saccharomyces cerevisiae.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Transcription factor II H

Transcription factor II Human (Transcription Factor II H; TFIIH) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways.

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Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text.

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Translation (biology)

In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.

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Trichothiodystrophy (TTD) is an autosomal recessive inherited disorder characterised by brittle hair and intellectual impairment.

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UvrABC endonuclease

UvrABC endonuclease is a multienzyme complex in Escherichia coli involved in DNA repair by nucleotide excision repair, and it is, therefore, sometimes called an excinuclease.

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Werner syndrome

Werner syndrome (WS), also known as "adult progeria",James, William; Berger, Timothy; Elston, Dirk (2005).

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Werner syndrome helicase

"Werner syndrome ATP-dependent helicase" also known as DNA helicase, RecQ-like type 3 is an enzyme that in humans is encoded by the WRN gene.

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ATPase WRNIP1 is an enzyme that in humans is encoded by the WRNIP1 gene.

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Xeroderma pigmentosum

Xeroderma pigmentosum (XP) is a genetic disorder in which there is a decreased ability to repair DNA damage such as that caused by ultraviolet (UV) light.

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Redirects here:

3' to 5' DNA helicase, 3'-5' PfDH, 5' to 3' DNA helicase, ATP phosphohydrolase (DNA helix unwinding), ATP phosphohydrolase (RNA helix unwinding), AvDH1, BACH1 helicase, BLM protein, BRCA1-associated C-terminal helicase, BcMCM, CSFV NS3 helicase, CeWRN-1, DBP2, DDX25, DDX3, DDX4, DEAD-box protein DED1, DEAH-box RNA helicase, DEAH-box protein 2, DED1, DNA Helicase, DNA helicase, DNA helicase 120, DNA helicase A, DNA helicase E, DNA helicase II, DNA helicase III, DNA helicase RECQL5beta, DNA helicase VI, Dbp9p, DbpA, Dex(H/D) RNA helicase, DmRECQ5, Dna Helicases, Dna helicases, DnaB helicase E1, EC, EC, EIF4A helicase, EhDEAD1, EhDEAD1 RNA helicase, GRTH/DDX25, HHcsA, HPif1, Hel E, Helicase HDH IV, Helicases, Helocase, Hmi1p, KOKV helicase, MCM helicase, MCM protein, MER3 helicase, MER3 protein, MPH1, Mtr4p, NPH-II, Nonstructural protein 3 helicase, PDH120, PIF1, PcrA helicase, PfDH A, Pfh1p, RNA Helicase, RNA helicase, RNA helicase DDX3, RNA helicase Hera, RNA-dependent ATPase, Rna helicases, TGBp1 NTPase/helicase domain, VRH1.


[1] https://en.wikipedia.org/wiki/Helicase

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