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Walker motifs

Index Walker motifs

The Walker A and Walker B motifs are protein sequence motifs, known to have highly conserved three-dimensional structures. [1]

63 relations: AAA proteins, Adenine, Adenosine triphosphate, Alpha helix, Amino acid, Arginine, Aromatic amino acid, Aspartic acid, ATP synthase, Autophosphorylation, Beta sheet, Calcium, CAMK, Cell signaling, Conformational change, Cyclin-dependent kinase, Cysteine, Cysteine synthase, DEAD box, Enzyme, G protein, G protein–coupled receptor, Glutamic acid, Glycine, Guanosine triphosphate, Helicase, Hydrophobe, Intrinsically disordered proteins, John E. Walker, Kinase, Leucine, Lysine, Magnesium, Manganese, Myosin, N-terminus, Nest (protein structural motif), Nucleoside-diphosphate kinase, Nucleotide, Phosphatase, Phosphate, Phosphatidylinositol phosphate kinases, Phospholipid, Phosphoprotein, Phosphorylation, Phosphotransferase, Protein, Protein primary structure, Protein tyrosine phosphatase, Pyridoxal phosphate, ..., RecA, Sequence motif, Serine, Signal transduction, Structural motif, Threonine, Thymidine kinase, Thymidine kinase in clinical chemistry, Thymidylate kinase, Transducin, Tyrosine, Tyrosine kinase, Wall-Associated Kinase. Expand index (13 more) »

AAA proteins

AAA proteins or ATPases associated with diverse cellular activities are a protein family sharing a common conserved module of approximately 230 amino acid residues.

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Adenine (A, Ade) is a nucleobase (a purine derivative).

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Adenosine triphosphate

Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.

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Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.

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Aromatic amino acid

An aromatic amino acid (AAA) is an amino acid that includes an aromatic ring.

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Aspartic acid

Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.

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ATP synthase

ATP synthase is an enzyme that creates the energy storage molecule adenosine triphosphate (ATP).

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Autophosphorylation is a type of post-translational modification of proteins.

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Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

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Calcium is a chemical element with symbol Ca and atomic number 20.

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CAMK, also written as CaMK, is an abbreviation for the Ca2+/calmodulin-dependent protein kinase class of enzymes.

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Cell signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.

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Conformational change

In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

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Cyclin-dependent kinase

Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin-dependent kinases (CDKs) are a family of sugar kinases first discovered for their role in regulating the cell cycle.

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Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Cysteine synthase

In enzymology, a cysteine synthase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are O3-acetyl-L-serine and hydrogen sulfide, whereas its two products are L-cysteine and acetate.

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DEAD box

DEAD box proteins are involved in an assortment of metabolic processes that typically involve RNAs, but in some cases also other nucleic acids.

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Enzymes are macromolecular biological catalysts.

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G protein

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

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G protein–coupled receptor

G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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Glycine (symbol Gly or G) is the amino acid that has a single hydrogen atom as its side chain.

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Guanosine triphosphate

Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate.

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Helicases are a class of enzymes vital to all living organisms.

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In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.

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Intrinsically disordered proteins

An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure.

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John E. Walker

Sir John Ernest Walker One or more of the preceding sentences incorporates text from the royalsociety.org website where: (born 7 January 1941) is a British chemist who won the Nobel Prize in Chemistry in 1997.

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In biochemistry, a kinase is an enzyme that catalyzes the transfer of phosphate groups from high-energy, phosphate-donating molecules to specific substrates.

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Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.

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Lysine (symbol Lys or K) is an α-amino acid that is used in the biosynthesis of proteins.

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Magnesium is a chemical element with symbol Mg and atomic number 12.

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Manganese is a chemical element with symbol Mn and atomic number 25.

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Myosins are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes.

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The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Nest (protein structural motif)

The Nest is a type of protein structural motif.

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Nucleoside-diphosphate kinase

Nucleoside-diphosphate kinases (NDPKs, also NDP kinase, (poly)nucleotide kinases and nucleoside diphosphokinases) are enzymes that catalyze the exchange of terminal phosphate between different nucleoside diphosphates (NDP) and triphosphates (NTP) in a reversible manner to produce nucleotide triphosphates.

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Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol.

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A phosphate is chemical derivative of phosphoric acid.

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Phosphatidylinositol phosphate kinases

Phosphatidylinositol phosphate kinases (PIPK) are kinases that phosphorylate the phosphoinositides PtdInsP and PtdInsP2 that are derivatives of phosphatidylinositol (PtdIns).

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Phospholipids are a class of lipids that are a major component of all cell membranes.

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A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group.

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In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.

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Phosphotransferases are a category of enzymes (EC number 2.7) that catalyze phosphorylation reactions.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein primary structure

Protein primary structure is the linear sequence of amino acids in a peptide or protein.

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Protein tyrosine phosphatase

Protein tyrosine phosphatases are a group of enzymes that remove phosphate groups from phosphorylated tyrosine residues on proteins.

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Pyridoxal phosphate

Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions.

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RecA is a 38 kilodalton protein essential for the repair and maintenance of DNA.

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Sequence motif

In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.

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Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Structural motif

In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.

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Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins.

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Thymidine kinase

Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC

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Thymidine kinase in clinical chemistry

Thymidine kinase is an enzyme, a phosphotransferase (a kinase): 2'-deoxythymidine kinase, ATP-thymidine 5'-phosphotransferase, EC that catalyzes the reaction: Thd + ATP → TMP + ADP where Thd is (deoxy)thymidine, ATP is adenosine 5’-triphosphate, TMP is (deoxy)thymidine 5’-phosphate and ADP is adenosine 5’-diphosphate.

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Thymidylate kinase

Thymidylate kinase (dTMP kinase) catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium: Thymidylate kinase is a ubiquitous enzyme of about 25 Kd and is important in the dTTP synthesis pathway for DNA synthesis.

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Transducin (Gt) is a protein naturally expressed in vertebrate retina rods and cones and it is very important in vertebrate phototransduction.

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Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.

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Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.

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Wall-Associated Kinase

Also known as WAK, wall-associated kinases are a family of protein kinases that connect the innermost portion of the cell (the cytoplasm) to the cell wall.

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Redirects here:

P-loop, Phosphate transport proteins, Phosphate-binding proteins, Walker A box, Walker A motif, Walker B motif, Walker motif A, Walker motif B.


[1] https://en.wikipedia.org/wiki/Walker_motifs

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