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P53

Index P53

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. [1]

Table of Contents

  1. 249 relations: Adenoviridae, Ageing, Amino acid, Aneuploidy, Angiogenesis, ANKRD2, Apoptosis, Aprataxin, Arginine, Arnold J. Levine, Ataxia telangiectasia and Rad3 related, ATF3, ATM serine/threonine kinase, Aurora kinase A, BARD1, Base pair, Bcl-2 homologous antagonist killer, Bert Vogelstein, Blastema, Bloom syndrome protein, BRCA1, BRCA2, BRCC3, BRE (gene), C-terminus, Cancer, Cancer Research UK, Carcinogenesis, Carcinoma in situ, CCAAT/enhancer binding protein zeta, CCNG1, CDC14A, CDC14B, Cell cycle, Cell nucleus, Cell potency, Cellular senescence, Cervical intraepithelial neoplasia, Cervix, CFLAR, CHEK1, CHEK2, Chemical substance, Chemokine, Chromosome 17, Chronic myelogenous leukemia, Collagen, type IV, alpha 3, Complementary DNA, Conformational change, CREB-binding protein, ... Expand index (199 more) »

  2. Aging-related proteins
  3. Apoptosis
  4. Tumor suppressor genes

Adenoviridae

Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome.

See P53 and Adenoviridae

Ageing

Ageing (or aging in American English) is the process of becoming older.

See P53 and Ageing

Amino acid

Amino acids are organic compounds that contain both amino and carboxylic acid functional groups.

See P53 and Amino acid

Aneuploidy

Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46.

See P53 and Aneuploidy

Angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis.

See P53 and Angiogenesis

ANKRD2

Ankyrin Repeat, PEST sequence and Proline-rich region (ARPP), also known as Ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the ANKRD2 gene. P53 and ANKRD2 are proteins.

See P53 and ANKRD2

Apoptosis

Apoptosis (from falling off) is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast. P53 and Apoptosis are programmed cell death.

See P53 and Apoptosis

Aprataxin

Aprataxin is a protein that in humans is encoded by the APTX gene.

See P53 and Aprataxin

Arginine

Arginine is the amino acid with the formula (H2N)(HN)CN(H)(CH2)3CH(NH2)CO2H.

See P53 and Arginine

Arnold J. Levine

Arnold Jay Levine (born 1939), is an American molecular biologist.

See P53 and Arnold J. Levine

Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1), is an enzyme that, in humans, is encoded by the ATR gene. P53 and ataxia telangiectasia and Rad3 related are proteins.

See P53 and Ataxia telangiectasia and Rad3 related

ATF3

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene. P53 and ATF3 are transcription factors.

See P53 and ATF3

ATM serine/threonine kinase

ATM serine/threonine kinase or Ataxia-telangiectasia mutated, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks (canonical pathway), oxidative stress, topoisomerase cleavage complexes, splicing intermediates, R-loops and in some cases by single-strand DNA breaks. P53 and ATM serine/threonine kinase are proteins.

See P53 and ATM serine/threonine kinase

Aurora kinase A

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.

See P53 and Aurora kinase A

BARD1

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. P53 and BARD1 are proteins.

See P53 and BARD1

Base pair

A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds.

See P53 and Base pair

Bcl-2 homologous antagonist killer

Bcl-2 homologous antagonist/killer is a protein which in humans is encoded by the BAK1 gene on chromosome 6. P53 and Bcl-2 homologous antagonist killer are apoptosis, programmed cell death and proteins.

See P53 and Bcl-2 homologous antagonist killer

Bert Vogelstein

Bert Vogelstein (born 1949) is director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a Howard Hughes Medical Institute investigator at The Johns Hopkins Medical School and Sidney Kimmel Comprehensive Cancer Center.

See P53 and Bert Vogelstein

Blastema

A blastema (Greek βλάστημα, "offspring") is a mass of cells capable of growth and regeneration into organs or body parts.

See P53 and Blastema

Bloom syndrome protein

Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome.

See P53 and Bloom syndrome protein

BRCA1

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 gene. P53 and BRCA1 are genes on human chromosome 17 and tumor suppressor genes.

See P53 and BRCA1

BRCA2

BRCA2 and BRCA2 are human genes and their protein products, respectively. P53 and BRCA2 are tumor suppressor genes.

See P53 and BRCA2

BRCC3

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.

See P53 and BRCC3

BRE (gene)

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.

See P53 and BRE (gene)

C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, carboxy tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

See P53 and C-terminus

Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

See P53 and Cancer

Cancer Research UK

Cancer Research UK (CRUK) is the world's largest independent cancer research organisation.

See P53 and Cancer Research UK

Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

See P53 and Carcinogenesis

Carcinoma in situ

Carcinoma in situ (CIS) is a group of abnormal cells.

See P53 and Carcinoma in situ

CCAAT/enhancer binding protein zeta

CCAAT/enhancer-binding protein zeta is a protein that in humans is encoded by the CEBPZ gene. P53 and CCAAT/enhancer binding protein zeta are transcription factors.

See P53 and CCAAT/enhancer binding protein zeta

CCNG1

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.

See P53 and CCNG1

CDC14A

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.

See P53 and CDC14A

CDC14B

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.

See P53 and CDC14B

Cell cycle

The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell that causes it to divide into two daughter cells.

See P53 and Cell cycle

Cell nucleus

The cell nucleus (nuclei) is a membrane-bound organelle found in eukaryotic cells.

See P53 and Cell nucleus

Cell potency

Cell potency is a cell's ability to differentiate into other cell types.

See P53 and Cell potency

Cellular senescence

Cellular senescence is a phenomenon characterized by the cessation of cell division.

See P53 and Cellular senescence

Cervical intraepithelial neoplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer.

See P53 and Cervical intraepithelial neoplasia

Cervix

The cervix (cervices) or cervix uteri is a dynamic fibromuscular organ of the female reproductive system that connects the vagina with the uterine cavity.

See P53 and Cervix

CFLAR

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.

See P53 and CFLAR

CHEK1

Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene.

See P53 and CHEK1

CHEK2

CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. P53 and CHEK2 are tumor suppressor genes.

See P53 and CHEK2

Chemical substance

A chemical substance is a unique form of matter with constant chemical composition and characteristic properties.

See P53 and Chemical substance

Chemokine

Chemokines, or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells.

See P53 and Chemokine

Chromosome 17

Chromosome 17 is one of the 23 pairs of chromosomes in humans. P53 and chromosome 17 are genes on human chromosome 17.

See P53 and Chromosome 17

Chronic myelogenous leukemia

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.

See P53 and Chronic myelogenous leukemia

Collagen, type IV, alpha 3

Collagen alpha-3(IV) chain is a protein that in humans is encoded by the COL4A3 gene.

See P53 and Collagen, type IV, alpha 3

Complementary DNA

In genetics, complementary DNA (cDNA) is DNA that was reverse transcribed (via reverse transcriptase) from an RNA (e.g., messenger RNA or microRNA).

See P53 and Complementary DNA

Conformational change

In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

See P53 and Conformational change

CREB-binding protein

CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3.

See P53 and CREB-binding protein

CREB1

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. P53 and CREB1 are transcription factors.

See P53 and CREB1

CXCL13

Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.

See P53 and CXCL13

CXCR5

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family.

See P53 and CXCR5

Cyclin H

Cyclin-H is a protein that in humans is encoded by the CCNH gene.

See P53 and Cyclin H

Cyclin-dependent kinase

Cyclin-dependent kinases (CDKs) are a predominant group of serine/threonine protein kinases involved in the regulation of the cell cycle and its progression, ensuring the integrity and functionality of cellular machinery.

See P53 and Cyclin-dependent kinase

Cyclin-dependent kinase 1

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. P53 and Cyclin-dependent kinase 1 are proteins.

See P53 and Cyclin-dependent kinase 1

Cyclin-dependent kinase 2

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. P53 and Cyclin-dependent kinase 2 are proteins.

See P53 and Cyclin-dependent kinase 2

Cyclin-dependent kinase 4

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene.

See P53 and Cyclin-dependent kinase 4

Cyclin-dependent kinase 6

Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.

See P53 and Cyclin-dependent kinase 6

Cyclin-dependent kinase 7

Cyclin-dependent kinase 7, or cell division protein kinase 7, is an enzyme that in humans is encoded by the CDK7 gene. P53 and Cyclin-dependent kinase 7 are proteins.

See P53 and Cyclin-dependent kinase 7

Cytosol

The cytosol, also known as cytoplasmic matrix or groundplasm, is one of the liquids found inside cells (intracellular fluid (ICF)).

See P53 and Cytosol

Dalton (unit)

The dalton or unified atomic mass unit (symbols: Da or u) is a non-SI unit of mass defined as of the mass of an unbound neutral atom of carbon-12 in its nuclear and electronic ground state and at rest.

See P53 and Dalton (unit)

Damping

In physical systems, damping is the loss of energy of an oscillating system by dissipation.

See P53 and Damping

David Lane (biologist)

Sir David Philip Lane (born 1 July 1952) is a British immunologist, molecular biologist and cancer researcher.

See P53 and David Lane (biologist)

Deletion (genetics)

In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is left out during DNA replication.

See P53 and Deletion (genetics)

DNA

Deoxyribonucleic acid (DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix.

See P53 and DNA

DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

See P53 and DNA repair

DNA-binding domain

A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.

See P53 and DNA-binding domain

DNA-PKcs

DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and has a number of other DNA housekeeping functions.

See P53 and DNA-PKcs

Dominance (genetics)

In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the effect of a different variant of the same gene on the other copy of the chromosome.

See P53 and Dominance (genetics)

Drug discovery

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.

See P53 and Drug discovery

E4F1

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene. P53 and E4F1 are transcription factors.

See P53 and E4F1

EFEMP2

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.

See P53 and EFEMP2

EGR1

EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene. P53 and EGR1 are transcription factors.

See P53 and EGR1

ELL (gene)

RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene.

See P53 and ELL (gene)

Embryonic stem cell

Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo.

See P53 and Embryonic stem cell

Endogeny (biology)

Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.

See P53 and Endogeny (biology)

EP300

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A.

See P53 and EP300

ERCC6

DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene.

See P53 and ERCC6

Exon

An exon is any part of a gene that will form a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.

See P53 and Exon

Feedback

Feedback occurs when outputs of a system are routed back as inputs as part of a chain of cause-and-effect that forms a circuit or loop.

See P53 and Feedback

G1 phase

The G1 phase, gap 1 phase, or growth 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division.

See P53 and G1 phase

G1/S transition

The G1/S transition is a stage in the cell cycle at the boundary between the G1 phase, in which the cell grows, and the S phase, during which DNA is replicated.

See P53 and G1/S transition

Gendicine

Gendicine is a gene therapy medication used to treat patients with head and neck squamous cell carcinoma linked to mutations in the ''TP53'' gene.

See P53 and Gendicine

Genetic code

The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or RNA sequences of nucleotide triplets, or codons) into proteins.

See P53 and Genetic code

Genome

In the fields of molecular biology and genetics, a genome is all the genetic information of an organism.

See P53 and Genome

Genome instability

Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.

See P53 and Genome instability

Glycogen synthase kinase-3 beta

Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene.

See P53 and Glycogen synthase kinase-3 beta

GNL3

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.

See P53 and GNL3

GPS2 (gene)

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene. P53 and GPS2 (gene) are genes on human chromosome 17.

See P53 and GPS2 (gene)

Guillermina Lozano

Guillermina 'Gigi' Lozano is an American geneticist.

See P53 and Guillermina Lozano

Head and neck cancer

Head and neck cancer is a general term encompassing multiple cancers that can develop in the head and neck region.

See P53 and Head and neck cancer

Heat shock protein 90kDa alpha (cytosolic), member A1

Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene.

See P53 and Heat shock protein 90kDa alpha (cytosolic), member A1

HIF1A

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. P53 and HIF1A are transcription factors.

See P53 and HIF1A

HIPK1

Homeodomain-interacting protein kinase 1 is an enzyme that, in humans is encoded by the HIPK1 gene.

See P53 and HIPK1

HIPK2

Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.

See P53 and HIPK2

HMGB1

High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene. P53 and HMGB1 are transcription factors.

See P53 and HMGB1

Hp53int1

Human protein 53 intron 1 (Hp53int1) is a protein encoded by the Hp53int1 gene in humans.

See P53 and Hp53int1

HSPA9

Mitochondrial 70kDa heat shock protein (mtHsp70), also known as mortalin, is a protein that in humans is encoded by the HSPA9 gene.

See P53 and HSPA9

Human papillomavirus infection

Human papillomavirus infection (HPV infection) is caused by a DNA virus from the Papillomaviridae family.

See P53 and Human papillomavirus infection

Huntingtin

Huntingtin (Htt) is the protein coded for in humans by the HTT gene, also known as the IT15 ("interesting transcript 15") gene.

See P53 and Huntingtin

Hypoxia (medicine)

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.

See P53 and Hypoxia (medicine)

Hypoxia-inducible factor

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. P53 and hypoxia-inducible factor are transcription factors.

See P53 and Hypoxia-inducible factor

IκBα

IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; NFKBIA) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. P53 and IκBα are transcription factors.

See P53 and IκBα

Immunohistochemistry

Immunohistochemistry is a form of immunostaining.

See P53 and Immunohistochemistry

Implantation (embryology)

Implantation, also known as nidation, is the stage in the mammalian embryonic development in which the blastocyst hatches, attaches, adheres, and invades into the endometrium of the female's uterus.

See P53 and Implantation (embryology)

ING1

Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene. P53 and ING1 are transcription factors.

See P53 and ING1

ING4

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene. P53 and ING4 are transcription factors.

See P53 and ING4

ING5

Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.

See P53 and ING5

Intrinsically disordered proteins

In molecular biology, an intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure, typically in the absence of its macromolecular interaction partners, such as other proteins or RNA.

See P53 and Intrinsically disordered proteins

Ionizing radiation

Ionizing radiation (US, ionising radiation in the UK), including nuclear radiation, consists of subatomic particles or electromagnetic waves that have sufficient energy to ionize atoms or molecules by detaching electrons from them.

See P53 and Ionizing radiation

Johns Hopkins School of Medicine

The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland.

See P53 and Johns Hopkins School of Medicine

Johns Hopkins University

Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, Johns, or JHU) is a private research university in Baltimore, Maryland.

See P53 and Johns Hopkins University

KPNB1

Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene. P53 and KPNB1 are genes on human chromosome 17.

See P53 and KPNB1

Lability

Lability refers to something that is constantly undergoing change or is likely to undergo change.

See P53 and Lability

Leukemia inhibitory factor

Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation.

See P53 and Leukemia inhibitory factor

Li–Fraumeni syndrome

Li–Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary disorder that predisposes carriers to cancer development.

See P53 and Li–Fraumeni syndrome

Lionel Crawford

Dr Lionel Vivian Crawford (born 1932) is a British cancer expert and virologist.

See P53 and Lionel Crawford

Lloyd J. Old

Lloyd John Old (September 23, 1933 – November 28, 2011) was one of the founders and standard-bearers of the field of cancer immunology.

See P53 and Lloyd J. Old

LMO3

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.

See P53 and LMO3

Mammal

A mammal is a vertebrate animal of the class Mammalia.

See P53 and Mammal

Mathematical model

A mathematical model is an abstract description of a concrete system using mathematical concepts and language.

See P53 and Mathematical model

MD Anderson Cancer Center

The University of Texas MD Anderson Cancer Center (colloquially MD Anderson Cancer Center) is a comprehensive cancer center in Houston, Texas.

See P53 and MD Anderson Cancer Center

Mdm2

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. P53 and Mdm2 are proteins.

See P53 and Mdm2

MDM4

Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.

See P53 and MDM4

MED1

Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. P53 and MED1 are genes on human chromosome 17.

See P53 and MED1

Memorial Sloan Kettering Cancer Center

Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in Manhattan in New York City.

See P53 and Memorial Sloan Kettering Cancer Center

Messenger RNA

In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein.

See P53 and Messenger RNA

MicroRNA

MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides.

See P53 and MicroRNA

Mir-145

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 gene. P53 and mir-145 are tumor suppressor genes.

See P53 and Mir-145

MIR34A

MicroRNA 34a (miR-34a) is a MicroRNA that in humans is encoded by the MIR34A gene.

See P53 and MIR34A

Mitogen-activated protein kinase

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines.

See P53 and Mitogen-activated protein kinase

Mitogen-activated protein kinase 9

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

See P53 and Mitogen-activated protein kinase 9

MNAT1

CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.

See P53 and MNAT1

Molecular mass

The molecular mass (m) is the mass of a given molecule.

See P53 and Molecular mass

Multisynthetase complex auxiliary component p38

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.

See P53 and Multisynthetase complex auxiliary component p38

Mutagen

In genetics, a mutagen is a physical or chemical agent that permanently changes genetic material, usually DNA, in an organism and thus increases the frequency of mutations above the natural background level.

See P53 and Mutagen

Mutation

In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA.

See P53 and Mutation

Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. P53 and Myc are transcription factors.

See P53 and Myc

Mycoplasma

Mycoplasma is a genus of bacteria that, like the other members of the class Mollicutes, lack a cell wall, and its peptidoglycan, around their cell membrane.

See P53 and Mycoplasma

N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. P53 and n-terminus are proteins.

See P53 and N-terminus

NDN (gene)

Necdin is a protein that in humans is encoded by the NDN gene.

See P53 and NDN (gene)

Negative feedback

Negative feedback (or balancing feedback) occurs when some function of the output of a system, process, or mechanism is fed back in a manner that tends to reduce the fluctuations in the output, whether caused by changes in the input or by other disturbances.

See P53 and Negative feedback

Neoplasm

A neoplasm is a type of abnormal and excessive growth of tissue.

See P53 and Neoplasm

NF-κB

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA, cytokine production and cell survival. P53 and NF-κB are aging-related proteins, programmed cell death and transcription factors.

See P53 and NF-κB

Nuclear export signal

A nuclear export signal (NES) is a short target peptide containing 4 hydrophobic residues in a protein that targets it for export from the cell nucleus to the cytoplasm through the nuclear pore complex using nuclear transport.

See P53 and Nuclear export signal

Nuclear localization sequence

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.

See P53 and Nuclear localization sequence

Nucleolin

Nucleolin is a protein that in humans is encoded by the NCL gene. P53 and Nucleolin are proteins.

See P53 and Nucleolin

NUMB (gene)

Protein numb homolog is a protein that in humans is encoded by the NUMB gene.

See P53 and NUMB (gene)

Oncogene

An oncogene is a gene that has the potential to cause cancer.

See P53 and Oncogene

Online Mendelian Inheritance in Man

Online Mendelian Inheritance in Man (OMIM) is a continuously updated catalog of human genes and genetic disorders and traits, with a particular focus on the gene-phenotype relationship.

See P53 and Online Mendelian Inheritance in Man

Oscillation

Oscillation is the repetitive or periodic variation, typically in time, of some measure about a central value (often a point of equilibrium) or between two or more different states.

See P53 and Oscillation

Osmotic shock

Osmotic shock or osmotic stress is physiologic dysfunction caused by a sudden change in the solute concentration around a cell, which causes a rapid change in the movement of water across its cell membrane.

See P53 and Osmotic shock

Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

See P53 and Oxidative stress

P14arf

p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus).

See P53 and P14arf

P16

p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. P53 and p16 are tumor suppressor genes.

See P53 and P16

P21

p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2. P53 and p21 are tumor suppressor genes.

See P53 and P21

PARC (gene)

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.

See P53 and PARC (gene)

PARP1

Poly polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. P53 and PARP1 are aging-related proteins.

See P53 and PARP1

PCAF

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

See P53 and PCAF

PIAS1

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.

See P53 and PIAS1

Pifithrin

Pifithrin-α (chemical name 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide) is an off-white in color chemical inhibitor of p53.

See P53 and Pifithrin

PIN1

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene.

See P53 and PIN1

PLAGL1

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.

See P53 and PLAGL1

PLK3

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

See P53 and PLK3

Polymorphism (biology)

In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.

See P53 and Polymorphism (biology)

Princeton University

Princeton University is a private Ivy League research university in Princeton, New Jersey.

See P53 and Princeton University

PRKRA

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.

See P53 and PRKRA

Programmed cell death

Programmed cell death (PCD; sometimes referred to as cellular suicide) is the death of a cell as a result of events inside of a cell, such as apoptosis or autophagy. P53 and Programmed cell death are apoptosis.

See P53 and Programmed cell death

Prohibitin

Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene. P53 and Prohibitin are genes on human chromosome 17.

See P53 and Prohibitin

Proline

Proline (symbol Pro or P) is an organic acid classed as a proteinogenic amino acid (used in the biosynthesis of proteins), although it does not contain the amino group but is rather a secondary amine.

See P53 and Proline

Promyelocytic leukemia protein

Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene.

See P53 and Promyelocytic leukemia protein

Proteasome

Proteasomes are protein complexes which degrade ubiquitin-tagged proteins by proteolysis, a chemical reaction that breaks peptide bonds. P53 and Proteasome are apoptosis and proteins.

See P53 and Proteasome

Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. P53 and Protein are proteins.

See P53 and Protein

Protein domain

In molecular biology, a protein domain is a region of a protein's polypeptide chain that is self-stabilizing and that folds independently from the rest.

See P53 and Protein domain

Protein isoform

A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

See P53 and Protein isoform

Protein kinase

A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.

See P53 and Protein kinase

Protein kinase R

Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene on chromosome 2.

See P53 and Protein kinase R

Protein–protein interaction

Protein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.

See P53 and Protein–protein interaction

PSME3

Proteasome activator complex subunit 3 is a protein that in humans is encoded by the PSME3 gene. P53 and PSME3 are genes on human chromosome 17.

See P53 and PSME3

PTEN (gene)

Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. P53 and PTEN (gene) are tumor suppressor genes.

See P53 and PTEN (gene)

PTK2

PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.

See P53 and PTK2

PTTG1

Securin is a protein that in humans is encoded by the PTTG1 gene.

See P53 and PTTG1

RAD51

DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51.

See P53 and RAD51

Radiation

In physics, radiation is the emission or transmission of energy in the form of waves or particles through space or a material medium.

See P53 and Radiation

RCHY1

RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene.

See P53 and RCHY1

RELA

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene. P53 and RELA are transcription factors.

See P53 and RELA

Replication protein A1

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene. P53 and Replication protein A1 are genes on human chromosome 17.

See P53 and Replication protein A1

Reprimo

Reprimo (RPRM), is a gene located at human chromosome 2q23 whose expression in conjunction with p53, along with other genes which are p53-induced, is associated with the arrest of the cell cycle at the G2 phase.

See P53 and Reprimo

Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. P53 and retinoblastoma protein are transcription factors and tumor suppressor genes.

See P53 and Retinoblastoma protein

S phase

S phase (Synthesis phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.

See P53 and S phase

S100B

S100 calcium-binding protein B (S100B) is a protein of the S100 protein family. P53 and S100B are genes mutated in mice.

See P53 and S100B

Science (journal)

Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.

See P53 and Science (journal)

SDS-PAGE

SDS-PAGE (sodium dodecyl sulfate–polyacrylamide gel electrophoresis) is a discontinuous electrophoretic system developed by Ulrich K. Laemmli which is commonly used as a method to separate proteins with molecular masses between 5 and 250 kDa.

See P53 and SDS-PAGE

Sequence homology

Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.

See P53 and Sequence homology

Sirtuin 1

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. P53 and sirtuin 1 are aging-related proteins.

See P53 and Sirtuin 1

Sirtuin 7

NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. P53 and sirtuin 7 are genes on human chromosome 17.

See P53 and Sirtuin 7

SMARCA4

Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

See P53 and SMARCA4

SMARCB1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene. P53 and SMARCB1 are tumor suppressor genes.

See P53 and SMARCB1

SMN1

Survival of motor neuron 1 (SMN1), also known as component of gems 1 or GEMIN1, is a gene that encodes the SMN protein in humans.

See P53 and SMN1

STAT3

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. P53 and STAT3 are genes on human chromosome 17, proteins and transcription factors.

See P53 and STAT3

Stem cell

In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely to produce more of the same stem cell.

See P53 and Stem cell

Stem-cell niche

Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate cell fate.

See P53 and Stem-cell niche

SUMO1

Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene.

See P53 and SUMO1

Sun tanning

Sun tanning or tanning is the process whereby skin color is darkened or tanned.

See P53 and Sun tanning

SV40

SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans.

See P53 and SV40

Systems biology

Systems biology is the computational and mathematical analysis and modeling of complex biological systems.

See P53 and Systems biology

TATA-binding protein

The TATA-binding protein (TBP) is a general transcription factor that binds to a DNA sequence called the TATA box. P53 and TATA-binding protein are proteins and transcription factors.

See P53 and TATA-binding protein

Telomere

A telomere is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes (see Sequences).

See P53 and Telomere

TFAP2A

Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene. P53 and TFAP2A are transcription factors.

See P53 and TFAP2A

TFDP1

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.

See P53 and TFDP1

TOP1

DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.

See P53 and TOP1

TOP2A

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. P53 and TOP2A are genes on human chromosome 17.

See P53 and TOP2A

TOP2B

DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.

See P53 and TOP2B

TP53-inducible glycolysis and apoptosis regulator

The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene. P53 and TP53-inducible glycolysis and apoptosis regulator are apoptosis.

See P53 and TP53-inducible glycolysis and apoptosis regulator

TP53BP1

Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.

See P53 and TP53BP1

TP53BP2

Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene.

See P53 and TP53BP2

TP53INP1

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.

See P53 and TP53INP1

TP53RK

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.

See P53 and TP53RK

Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. P53 and transcription factor are transcription factors.

See P53 and Transcription factor

Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.

See P53 and Transcriptional regulation

TSG101

Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.

See P53 and TSG101

Tumor antigen

Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host.

See P53 and Tumor antigen

Tumor hypoxia

Tumor hypoxia is the situation where tumor cells have been deprived of oxygen.

See P53 and Tumor hypoxia

Tumor suppressor gene

A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. P53 and tumor suppressor gene are tumor suppressor genes.

See P53 and Tumor suppressor gene

UBE2A

Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.

See P53 and UBE2A

UBE2I

SUMO-conjugating enzyme UBC9 is an enzyme that in humans is encoded by the UBE2I gene.

See P53 and UBE2I

Ubiquitin

Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. P53 and Ubiquitin are proteins.

See P53 and Ubiquitin

Ubiquitin C

Polyubiquitin-C is a protein encoded by the UBC gene in humans.

See P53 and Ubiquitin C

Ubiquitin ligase

A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate.

See P53 and Ubiquitin ligase

Ultraviolet

Ultraviolet (UV) light is electromagnetic radiation of wavelengths of 10–400 nanometers, shorter than that of visible light, but longer than X-rays.

See P53 and Ultraviolet

UniProt

UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects.

See P53 and UniProt

USP10

Ubiquitin specific peptidase 10, also known as USP10, is an enzyme which in humans is encoded by the USP10 gene.

See P53 and USP10

USP42

Ubiquitin carboxyl-terminal hydrolase 42 is an enzyme that in humans is encoded by the USP42 gene.

See P53 and USP42

USP7

Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is an enzyme that in humans is encoded by the USP7 gene.

See P53 and USP7

Vertebrate

Vertebrates are deuterostomal animals with bony or cartilaginous axial endoskeleton — known as the vertebral column, spine or backbone — around and along the spinal cord, including all fish, amphibians, reptiles, birds and mammals.

See P53 and Vertebrate

Viral pneumonia

Viral pneumonia is a pneumonia caused by a virus.

See P53 and Viral pneumonia

Virus

A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism.

See P53 and Virus

Wart

Warts are non-cancerous viral growths usually occurring on the hands and feet but which can also affect other locations, such as the genitals or face.

See P53 and Wart

Weizmann Institute of Science

The Weizmann Institute of Science (מכון ויצמן למדע Machon Weizmann LeMada) is a public research university in Rehovot, Israel, established in 1934, fourteen years before the State of Israel was founded.

See P53 and Weizmann Institute of Science

Werner syndrome helicase

Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene.

See P53 and Werner syndrome helicase

Wild type

The wild type (WT) is the phenotype of the typical form of a species as it occurs in nature.

See P53 and Wild type

WWOX

WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene.

See P53 and WWOX

XPB

XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

See P53 and XPB

Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene. P53 and y box binding protein 1 are transcription factors.

See P53 and Y box binding protein 1

YPEL3

Yippee-like 3 (Drosophila) is a protein that in humans is encoded by the YPEL3 gene.

See P53 and YPEL3

YWHAZ

14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8.

See P53 and YWHAZ

ZNF148

Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene. P53 and ZNF148 are transcription factors.

See P53 and ZNF148

60S ribosomal protein L11

60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.

See P53 and 60S ribosomal protein L11

See also

Aging-related proteins

Apoptosis

Tumor suppressor genes

References

[1] https://en.wikipedia.org/wiki/P53

Also known as Antigen NY-CO-13, Cellular tumor antigen p53, Genes, p53, Guardian of the Genome, P53 (protein), P53 expression, P53 gene, P53 protein, P53 signaling pathway, P53 tumor suppressor, Phosphoprotein p53, Protein P53, TP53, TP53 (gene), TP53 (version 2), TP53 gene, TRP53, The guardian of the genome, Tumor protein, Tumor suppressor p53, Tumor suppressor protein p53.

, CREB1, CXCL13, CXCR5, Cyclin H, Cyclin-dependent kinase, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Cyclin-dependent kinase 7, Cytosol, Dalton (unit), Damping, David Lane (biologist), Deletion (genetics), DNA, DNA repair, DNA-binding domain, DNA-PKcs, Dominance (genetics), Drug discovery, E4F1, EFEMP2, EGR1, ELL (gene), Embryonic stem cell, Endogeny (biology), EP300, ERCC6, Exon, Feedback, G1 phase, G1/S transition, Gendicine, Genetic code, Genome, Genome instability, Glycogen synthase kinase-3 beta, GNL3, GPS2 (gene), Guillermina Lozano, Head and neck cancer, Heat shock protein 90kDa alpha (cytosolic), member A1, HIF1A, HIPK1, HIPK2, HMGB1, Hp53int1, HSPA9, Human papillomavirus infection, Huntingtin, Hypoxia (medicine), Hypoxia-inducible factor, IκBα, Immunohistochemistry, Implantation (embryology), ING1, ING4, ING5, Intrinsically disordered proteins, Ionizing radiation, Johns Hopkins School of Medicine, Johns Hopkins University, KPNB1, Lability, Leukemia inhibitory factor, Li–Fraumeni syndrome, Lionel Crawford, Lloyd J. Old, LMO3, Mammal, Mathematical model, MD Anderson Cancer Center, Mdm2, MDM4, MED1, Memorial Sloan Kettering Cancer Center, Messenger RNA, MicroRNA, Mir-145, MIR34A, Mitogen-activated protein kinase, Mitogen-activated protein kinase 9, MNAT1, Molecular mass, Multisynthetase complex auxiliary component p38, Mutagen, Mutation, Myc, Mycoplasma, N-terminus, NDN (gene), Negative feedback, Neoplasm, NF-κB, Nuclear export signal, Nuclear localization sequence, Nucleolin, NUMB (gene), Oncogene, Online Mendelian Inheritance in Man, Oscillation, Osmotic shock, Oxidative stress, P14arf, P16, P21, PARC (gene), PARP1, PCAF, PIAS1, Pifithrin, PIN1, PLAGL1, PLK3, Polymorphism (biology), Princeton University, PRKRA, Programmed cell death, Prohibitin, Proline, Promyelocytic leukemia protein, Proteasome, Protein, Protein domain, Protein isoform, Protein kinase, Protein kinase R, Protein–protein interaction, PSME3, PTEN (gene), PTK2, PTTG1, RAD51, Radiation, RCHY1, RELA, Replication protein A1, Reprimo, Retinoblastoma protein, S phase, S100B, Science (journal), SDS-PAGE, Sequence homology, Sirtuin 1, Sirtuin 7, SMARCA4, SMARCB1, SMN1, STAT3, Stem cell, Stem-cell niche, SUMO1, Sun tanning, SV40, Systems biology, TATA-binding protein, Telomere, TFAP2A, TFDP1, TOP1, TOP2A, TOP2B, TP53-inducible glycolysis and apoptosis regulator, TP53BP1, TP53BP2, TP53INP1, TP53RK, Transcription factor, Transcriptional regulation, TSG101, Tumor antigen, Tumor hypoxia, Tumor suppressor gene, UBE2A, UBE2I, Ubiquitin, Ubiquitin C, Ubiquitin ligase, Ultraviolet, UniProt, USP10, USP42, USP7, Vertebrate, Viral pneumonia, Virus, Wart, Weizmann Institute of Science, Werner syndrome helicase, Wild type, WWOX, XPB, Y box binding protein 1, YPEL3, YWHAZ, ZNF148, 60S ribosomal protein L11.