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Index P53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice). [1]

237 relations: Adenoviridae, Ageing, Amino acid, Aneuploidy, Angiogenesis, ANKRD2, Apoptosis, Aprataxin, Arginine, Arnold J. Levine, Ataxia telangiectasia and Rad3 related, ATF3, ATM serine/threonine kinase, Aurora A kinase, BARD1, Bcl-2 homologous antagonist killer, Bert Vogelstein, Blastema, Bloom syndrome protein, BRCA1, BRCA2, BRCC3, BRE (gene), C-terminus, Cancer, Cancer Research UK, Carcinogenesis, Carcinoma in situ, CCAAT/enhancer binding protein zeta, CCNG1, CDC14A, CDC14B, Cell (biology), Cell cycle, Cell nucleus, Cell potency, Cervical intraepithelial neoplasia, Cervix, CFLAR, CHEK1, CHEK2, Chemical substance, Chemokine, Chromosome 17, Chronic myelogenous leukemia, Complementary DNA, Conformational change, CREB-binding protein, CREB1, CXCL13, ..., CXCR5, Cyclin H, Cyclin-dependent kinase, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Cyclin-dependent kinase 6, Cyclin-dependent kinase 7, Cytosol, Damping ratio, David Lane (oncologist), Deletion (genetics), DNA, DNA repair, DNA-binding domain, DNA-PKcs, Dominance (genetics), Drug discovery, E4F1, EFEMP2, EGR1, Elephant, ELL (gene), Embryonic stem cell, Endogeny (biology), EP300, ERCC6, G1 phase, G1/S transition, Gendicine, Gene, Gene knockout, Genetic code, Genome, GNL3, GPS2 (gene), GSK3B, Head and neck cancer, Heat shock protein 90kDa alpha (cytosolic), member A1, HIF1A, HIPK1, HIPK2, HMGB1, Homology (biology), HSPA9, Human papillomavirus infection, Huntingtin, Hypoxia (medical), Hypoxia-inducible factors, IκBα, Implantation (human embryo), Incidence (epidemiology), ING1, ING4, ING5, Intrinsically disordered proteins, Ionizing radiation, Johns Hopkins School of Medicine, Johns Hopkins University, KPNB1, Lability, Leukemia inhibitory factor, Li–Fraumeni syndrome, Lionel Crawford, Lloyd J. Old, LMO3, Mammal, Mathematical model, Mdm2, MDM4, MED1, Memorial Sloan Kettering Cancer Center, Messenger RNA, Mitogen-activated protein kinase, Mitogen-activated protein kinase 9, MNAT1, Molecular mass, Multicellular organism, Multisynthetase complex auxiliary component p38, Mutagen, Mutation, Myc, N-terminus, NDN (gene), Neoplasm, NF-κB, Nuclear localization sequence, Nucleolin, NUMB (gene), Oncogene, Online Mendelian Inheritance in Man, Oscillation, Osmotic shock, Oxidative stress, P14arf, P16, P21, PARC (gene), PARP1, PCAF, Peto's paradox, PIAS1, PIN1, PLAGL1, PLK3, Polymorphism (biology), Princeton University, PRKRA, Prohibitin, Proline, Promyelocytic leukemia protein, Proteasome, Protein, Protein domain, Protein isoform, Protein kinase, Protein kinase R, Protein–protein interaction, PSME3, PTEN (gene), PTK2, PTTG1, RAD51, Radiation, RCHY1, RELA, Replication protein A1, Reprimo, Retinoblastoma protein, Richard Peto, Russian Academy of Sciences, S phase, S100B, Science (journal), SDS-PAGE, Sirtuin 1, Sirtuin 7, Small ubiquitin-related modifier 1, SMARCA4, SMARCB1, SMN1, STAT3, Stem cell, Sun tanning, SV40, Systems biology, TATA-binding protein, Telomere, TFAP2A, TFDP1, TOP1, TOP2A, TOP2B, TP53-inducible glycolysis and apoptosis regulator, TP53BP1, TP53BP2, TP53INP1, TP53RK, Transcription factor, Transcription factor II D, Transcriptional regulation, TSG101, Tumor antigen, Tumor suppressor, UBE2A, UBE2I, Ubiquitin, Ubiquitin C, Ubiquitin ligase, Ultraviolet, Unified atomic mass unit, UniProt, USP42, USP7, Virus, Wart, Weizmann Institute of Science, Werner syndrome helicase, Whale, Wild type, WWOX, XPB, Y box binding protein 1, YPEL3, YWHAZ, ZNF148, 60S ribosomal protein L11. Expand index (187 more) »


Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome.

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Ageing or aging (see spelling differences) is the process of becoming older.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Aneuploidy is the presence of an abnormal number of chromosomes in a cell, for example a human cell having 45 or 47 chromosomes instead of the usual 46.

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Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.

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Ankyrin Repeat, PEST sequence and Proline-rich region (ARPP), also known as Ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the ANKRD2 gene.

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Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Aprataxin is a protein that in humans is encoded by the APTX gene.

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Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.

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Arnold J. Levine

Arnold J. Levine (born 1939), is an American Molecular biologist.

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Ataxia telangiectasia and Rad3 related

Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene.

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Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.

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ATM serine/threonine kinase

ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks.

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Aurora A kinase

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene.

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BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene.

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Bcl-2 homologous antagonist killer

Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the BAK1 gene on chromosome 6.

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Bert Vogelstein

Bert Vogelstein (born 1949) is Director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a Howard Hughes Medical Institute investigator at The Johns Hopkins Medical School and Sidney Kimmel Comprehensive Cancer Center.

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A blastema is a mass of cells capable of growth and regeneration into organs or body parts.

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Bloom syndrome protein

Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome.

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BRCA1 and BRCA1 are a human gene and its protein product, respectively.

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BRCA2 and BRCA2 are a human gene and its protein product, respectively.

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Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.

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BRE (gene)

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.

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The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cancer Research UK

Cancer Research UK is a cancer research and awareness charity in the United Kingdom and Isle of Man, formed on 4 February 2002 by the merger of The Cancer Research Campaign and the Imperial Cancer Research Fund.

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Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

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Carcinoma in situ

Carcinoma in situ (CIS), also known as in situ neoplasm, is a group of abnormal cells.

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CCAAT/enhancer binding protein zeta

CCAAT/enhancer-binding protein zeta is a protein that in humans is encoded by the CEBPZ gene.

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Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.

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Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.

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Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Cell potency

Cell potency is a cell's ability to differentiate into other cell types The more cell types a cell can differentiate into, the greater its potency.

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Cervical intraepithelial neoplasia

Cervical intraepithelial neoplasia (CIN), also known as cervical dysplasia, is the abnormal growth of cells on the surface of the cervix that could potentially lead to cervical cancer.

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The cervix or cervix uteri (neck of the uterus) is the lower part of the uterus in the human female reproductive system.

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CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.

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Checkpoint kinase 1, commonly referred to as Chk1 is an Serine/threonine-specific protein kinase that in humans, is encoded by the CHEK1 gene.

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CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase.

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Chemical substance

A chemical substance, also known as a pure substance, is a form of matter that consists of molecules of the same composition and structure.

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Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells.

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Chromosome 17

Chromosome 17 is one of the 23 pairs of chromosomes in humans.

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Chronic myelogenous leukemia

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.

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Complementary DNA

In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.

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Conformational change

In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

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CREB-binding protein

CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.

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CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.

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chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.

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C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family.

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Cyclin H

Cyclin-H is a protein that in humans is encoded by the CCNH gene.

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Cyclin-dependent kinase

Gap phase 2. The duration of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin-dependent kinases (CDKs) are a family of sugar kinases first discovered for their role in regulating the cell cycle.

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Cyclin-dependent kinase 1

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation.

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Cyclin-dependent kinase 2

Cyclin-dependent kinase 2, also known as cell division protein kinase 2, is an enzyme that in humans is encoded by the CDK2 gene.

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Cyclin-dependent kinase 4

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene.

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Cyclin-dependent kinase 6

Cell division protein kinase 6 (CDK6) is an enzyme encoded by the CDK6 gene.

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Cyclin-dependent kinase 7

Cell division protein kinase 7 is an enzyme that in humans is encoded by the CDK7 gene.

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The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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Damping ratio

Damping is an influence within or upon an oscillatory system that has the effect of reducing, restricting or preventing its oscillations.

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David Lane (oncologist)

Sir David Philip Lane FRCP FRCSEd FMedSci FRS FRSE (born 1952) is a British immunologist, molecular biologist and cancer researcher.

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Deletion (genetics)

In genetics, a deletion (also called gene deletion, deficiency, or deletion mutation) (sign: Δ) is a mutation (a genetic aberration) in which a part of a chromosome or a sequence of DNA is lost during DNA replication.

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Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.

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DNA-binding domain

A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.

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DNA-dependent protein kinase, catalytic subunit, also known as DNA-PKcs, is an enzyme that in humans is encoded by the gene designated as PRKDC or XRCC7.

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Dominance (genetics)

Dominance in genetics is a relationship between alleles of one gene, in which the effect on phenotype of one allele masks the contribution of a second allele at the same locus.

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Drug discovery

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.

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Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.

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EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.

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EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

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Elephants are large mammals of the family Elephantidae and the order Proboscidea.

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ELL (gene)

RNA polymerase II elongation factor ELL is an enzyme that in humans is encoded by the ELL gene.

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Embryonic stem cell

Embryonic stem cells (ES cells or ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo.

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Endogeny (biology)

Endogenous substances and processes are those that originate from within an organism, tissue, or cell.

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Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A.

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DNA excision repair protein ERCC-6 (also CS-B protein) is a protein that in humans is encoded by the ERCC6 gene.

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G1 phase

The g1 phase, or Gap 1 phase, is the first of four phases of the cell cycle that takes place in eukaryotic cell division.

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G1/S transition

The G1/S transition is a stage in the cell cycle at the boundary between the G1 phase, in which the cell grows, and the S phase, during which DNA is replicated.

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Gendicine is a recombinant adenovirus engineered to express wildtype-p53 (rAd-p53).

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In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene knockout

A gene knockout (abbreviation: KO) is a genetic technique in which one of an organism's genes is made inoperative ("knocked out" of the organism).

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Genetic code

The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or mRNA sequences) into proteins.

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In the fields of molecular biology and genetics, a genome is the genetic material of an organism.

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Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.

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GPS2 (gene)

G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.

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Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene.

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Head and neck cancer

Head and neck cancer is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands.

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Heat shock protein 90kDa alpha (cytosolic), member A1

Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene.

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Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene.

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Homeodomain-interacting protein kinase 1 is an enzyme that in humans is encoded by the HIPK1 gene.

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Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene.

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High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene.

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Homology (biology)

In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.

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Mitochondrial 70kDa heat shock protein (mtHsp70), also known as mortalin, is a protein that in humans is encoded by the HSPA9 gene.

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Human papillomavirus infection

Human papillomavirus infection is an infection by human papillomavirus (HPV).

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The huntingtin gene, also called the HTT or HD (Huntington disease) gene, is the IT15 ("interesting transcript 15") gene, which codes for a protein called the huntingtin protein.

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Hypoxia (medical)

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level.

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Hypoxia-inducible factors

Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia.

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IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor.

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Implantation (human embryo)

In humans, implantation is the stage of pregnancy at which the already fertilized egg adheres to the wall of the uterus.

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Incidence (epidemiology)

Incidence in epidemiology is a measure of the probability of occurrence of a given medical condition in a population within a specified period of time.

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Inhibitor of growth protein 1 is a protein that in humans is encoded by the ING1 gene.

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Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.

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Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.

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Intrinsically disordered proteins

An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure.

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Ionizing radiation

Ionizing radiation (ionising radiation) is radiation that carries enough energy to liberate electrons from atoms or molecules, thereby ionizing them.

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Johns Hopkins School of Medicine

The Johns Hopkins University School of Medicine (JHUSOM), located in Baltimore, Maryland, U.S.A. (founded in 1893) is the academic medical teaching and research arm of the Johns Hopkins University, founded in 1876.

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Johns Hopkins University

Johns Hopkins University is an American private research university in Baltimore, Maryland.

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Importin subunit beta-1 is a protein that in humans is encoded by the KPNB1 gene.

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Lability refers to something that is constantly undergoing change or something that is likely to undergo change.

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Leukemia inhibitory factor

Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation.

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Li–Fraumeni syndrome

Li–Fraumeni syndrome is a rare, autosomal dominant, hereditary disorder that pre-disposes carriers to cancer development.

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Lionel Crawford

Dr Lionel Vivian Crawford (born 1932) is a British cancer expert and virologist.

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Lloyd J. Old

Lloyd John Old (September 23, 1933 – November 28, 2011) was one of the founders and standard-bearers of the field of cancer immunology.

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LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.

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Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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Mathematical model

A mathematical model is a description of a system using mathematical concepts and language.

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Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene.

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Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.

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Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene.

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Memorial Sloan Kettering Cancer Center

Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in New York City, founded in 1884 as the New York Cancer Hospital.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Mitogen-activated protein kinase

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).

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Mitogen-activated protein kinase 9

Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.

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CDK-activating kinase assembly factor MAT1 is an enzyme that in humans is encoded by the MNAT1 gene.

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Molecular mass

Relative Molecular mass or molecular weight is the mass of a molecule.

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Multicellular organism

Multicellular organisms are organisms that consist of more than one cell, in contrast to unicellular organisms.

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Multisynthetase complex auxiliary component p38

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene.

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In genetics, a mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level.

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In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Myc is a family of regulator genes and proto-oncogenes that code for transcription factors.

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The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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NDN (gene)

Necdin is a protein that in humans is encoded by the NDN gene.

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Neoplasia is a type of abnormal and excessive growth of tissue.

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NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.

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Nuclear localization sequence

A nuclear localization signal or sequence (NLS) is an amino acid sequence that 'tags' a protein for import into the cell nucleus by nuclear transport.

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Nucleolin is a protein that in humans is encoded by the NCL gene.

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NUMB (gene)

Protein numb homolog is a protein that in humans is encoded by the NUMB gene.

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An oncogene is a gene that has the potential to cause cancer.

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Online Mendelian Inheritance in Man

Online Mendelian Inheritance in Man (OMIM) is a continuously updated catalog of human genes and genetic disorders and traits, with a particular focus on the gene-phenotype relationship.

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Oscillation is the repetitive variation, typically in time, of some measure about a central value (often a point of equilibrium) or between two or more different states.

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Osmotic shock

Osmotic shock or osmotic stress is physiologic dysfunction caused by a sudden change in the solute concentration around a cell, which causes a rapid change in the movement of water across its cell membrane.

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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p14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an alternate reading frame protein product of the CDKN2A locus (i.e. INK4a/ARF locus).

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p16 (also known as p16INK4a, cyclin-dependent kinase inhibitor 2A, multiple tumor suppressor 1 and as several other synonyms), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene.

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p21Cip1 (alternatively p21Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes, though is primarily associated with inhibition of CDK2.

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PARC (gene)

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.

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Poly polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly synthase 1 is an enzyme that in humans is encoded by the PARP1 gene.

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P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

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Peto's paradox

Peto's paradox is the observation, named after Richard Peto, that at the species level, the incidence of cancer does not appear to correlate with the number of cells in an organism.

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E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.

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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene.

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Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.

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Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

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Polymorphism (biology)

Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.

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Princeton University

Princeton University is a private Ivy League research university in Princeton, New Jersey.

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Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.

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Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene.

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Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.

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Promyelocytic leukemia protein

Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19) is the protein product of the PML gene.

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Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.

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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Protein isoform

A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.

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Protein kinase

A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).

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Protein kinase R

Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Proteasome activator complex subunit 3 is a protein that in humans is encoded by the PSME3 gene.

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PTEN (gene)

Phosphatase and tensin homolog (PTEN) is a protein that, in humans, is encoded by the PTEN gene.

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PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.

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Securin is a protein that in humans is encoded by the PTTG1 gene.

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RAD51 is a eukaryotic gene.

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In physics, radiation is the emission or transmission of energy in the form of waves or particles through space or through a material medium.

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RING finger and CHY zinc finger domain-containing protein 1 is a protein that in humans is encoded by the RCHY1 gene.

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Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

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Replication protein A1

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.

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Reprimo (RPRM), is a gene located at human chromosome 2q23 whose expression in conjunction with p53, along with other genes which are p53-induced, is associated with the arrest of the cell cycle at the G2 phase.

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Retinoblastoma protein

The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.

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Richard Peto

Sir Richard Peto (born 14 May 1943) is Professor of Medical Statistics and Epidemiology at the University of Oxford, England.

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Russian Academy of Sciences

The Russian Academy of Sciences (RAS; Росси́йская акаде́мия нау́к (РАН) Rossíiskaya akadémiya naúk) consists of the national academy of Russia; a network of scientific research institutes from across the Russian Federation; and additional scientific and social units such as libraries, publishing units, and hospitals.

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S phase

S phase (synthesis phase) is the part of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase.

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S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.

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Science (journal)

Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.

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SDS-PAGE (sodium dodecyl sulfate–polyacrylamide gel electrophoresis) is a variant of polyacrylamide gel electrophoresis, an analytical method in biochemistry for the separation of charged molecules in mixtures by their molecular masses in an electric field.

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Sirtuin 1

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.

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Sirtuin 7

NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene.

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Small ubiquitin-related modifier 1

Small ubiquitin-related modifier 1 is a protein that in humans is encoded by the SUMO1 gene.

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Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 is a protein that in humans is encoded by the SMARCB1 gene.

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Survival of motor neuron 1 (SMN1), also known as component of gems 1 or GEMIN1, is a gene that encodes the SMN protein in humans.

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Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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Sun tanning

Sun tanning or simply tanning is the process whereby skin color is darkened or tanned.

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SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans.

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Systems biology

Systems biology is the computational and mathematical modeling of complex biological systems.

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TATA-binding protein

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box.

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A telomere is a region of repetitive nucleotide sequences at each end of a chromosome, which protects the end of the chromosome from deterioration or from fusion with neighboring chromosomes.

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Transcription factor AP-2 alpha (Activating enhancer binding Protein 2 alpha), also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene.

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Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.

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DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene.

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DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.

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DNA topoisomerase 2-beta is an enzyme that in humans is encoded by the TOP2B gene.

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TP53-inducible glycolysis and apoptosis regulator

The TP53-inducible glycolysis and apoptosis regulator (TIGAR) also known as fructose-2,6-bisphosphatase TIGAR is an enzyme that in humans is encoded by the C12orf5 gene.

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Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.

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Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene.

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Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.

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TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Transcription factor II D

Transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.

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Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.

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Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.

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Tumor antigen

Tumor antigen is an antigenic substance produced in tumor cells, i.e., it triggers an immune response in the host.

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Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

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Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.

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SUMO-conjugating enzyme UBC9 is an enzyme that in humans is encoded by the UBE2I gene.

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Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.

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Ubiquitin C

Polyubiquitin-C is a protein encoded by the UBC gene in humans.

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Ubiquitin ligase

A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate.

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Ultraviolet (UV) is electromagnetic radiation with a wavelength from 10 nm to 400 nm, shorter than that of visible light but longer than X-rays.

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Unified atomic mass unit

The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).

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UniProt is a freely accessible database of protein sequence and functional information, many entries being derived from genome sequencing projects.

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Ubiquitin carboxyl-terminal hydrolase 42 is an enzyme that in humans is encoded by the USP42 gene.

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Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is an enzyme that in humans is encoded by the USP7 gene.

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A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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Warts are typically small, rough, and hard growths that are similar in color to the rest of the skin.

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Weizmann Institute of Science

The Weizmann Institute of Science (מכון ויצמן למדע Machon Weizmann LeMada) is a public research university in Rehovot, Israel, established in 1934, 14 years before the State of Israel.

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Werner syndrome helicase

"Werner syndrome ATP-dependent helicase" also known as DNA helicase, RecQ-like type 3 is an enzyme that in humans is encoded by the WRN gene.

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Whales are a widely distributed and diverse group of fully aquatic placental marine mammals.

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Wild type

Wild type (WT) refers to the phenotype of the typical form of a species as it occurs in nature.

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WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene.

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XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

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Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.

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Yippee-like 3 (Drosophila) is a protein that in humans is encoded by the YPEL3 gene.

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14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8.

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Zinc finger protein 148 is a protein that in humans is encoded by the ZNF148 gene.

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60S ribosomal protein L11

60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.

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Redirects here:

Antigen NY-CO-13, Cellular tumor antigen p53, Genes, p53, P53 (protein), P53 expression, P53 gene, P53 protein, P53 signaling pathway, P53 tumor suppressor, Phosphoprotein p53, Protein P53, TP53, TP53 (gene), TP53 (version 2), TP53 gene, TRP53, The guardian of the genome, Tp53 Gene, Tumor protein, Tumor suppressor p53, Tumor suppressor protein p53.


[1] https://en.wikipedia.org/wiki/P53

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