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Warfarin

Index Warfarin

Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner). [1]

219 relations: Acenocoumarol, Acta Crystallographica, Adverse drug reaction, Allele, American College of Chest Physicians, Anticoagulant, Antiphospholipid syndrome, Antiplatelet drug, Antithrombin, Apiaceae, Apixaban, Aromaticity, Artificial heart valve, Aspirin, Atrial fibrillation, Bait (luring substance), Bioaccumulation, Biological half-life, Bird of prey, Birth defect, Bleeding, Bone density, Bone fracture, Borage, Borage seed oil, Brachydactyly, Broad-spectrum antibiotic, Broccoli, Brodifacoum, Cabbage, Calcaneus, Calcification, Calcium, Caucasian race, Centers for Disease Control and Prevention, Centers for Medicare and Medicaid Services, Central nervous system, Cholesterol, Cholesterol embolism, Clopidogrel, Coagulation, Committee on Safety of Medicines, Contraindication, Coriander, Coumarin, Coumatetralyl, Cranberry, Cruciferous vegetables, CYP1A2, CYP2C19, ..., CYP2C9, CYP3A4, Dabigatran, Deep vein thrombosis, Department of Conservation (New Zealand), Des-gamma carboxyprothrombin, Developing country, Developmental disability, Dicoumarol, Diet (nutrition), Dill, Dipteryx odorata, Drug interaction, Drug metabolism, Dwight D. Eisenhower, Dysmelia, Edoxaban, Embolism, Emergency Planning and Community Right-to-Know Act, Enantiomer, Endothelium, Enoxaparin sodium, Enzyme, Enzyme induction and inhibition, Enzyme inhibitor, Epileptic seizure, Factor IX, Factor V, Factor VII, Factor VIII, Factor X, Femur, Fetal warfarin syndrome, Food and Drug Administration, Formaldehyde, Frank Schofield, Fresh frozen plasma, Galium odoratum, Gamma-glutamyl carboxylase, Gangrene, Generic drug, Ginger, Ginkgo biloba, Ginseng, Glutamic acid, Google Books, Gut flora, HAS-BLED, Health system, Hemiacetal, Hemodialysis, Heparin, Heparin-induced thrombocytopenia, Hepatotoxicity, Hierochloe odorata, Human–wildlife conflict, Hypericum perforatum, Hyperthyroidism, Hypoplasia, Hypothyroidism, Idarucizumab, Immediately dangerous to life or health, In utero, Intravenous therapy, Joseph Stalin, Karl Paul Link, Kidney, Lavandula, Lavrentiy Beria, Liquorice, List of extremely hazardous substances, Liver, Low birth weight, Low molecular weight heparin, Macrolide, Maintenance dose, Matrix gla protein, Mechanism of action, Medical guideline, Medicare (United States), Melilotus, Meta-analysis, Metronidazole, Miscarriage, Mist net, Mouse, Mycotoxin, Myocardial infarction, Nasal bridge, National Institute for Occupational Safety and Health, Nature (journal), Necrosis, Nikita Khrushchev, Nonsteroidal anti-inflammatory drug, Occupational Safety and Health Administration, Orthopedic surgery, Osteocalcin, Osteoporosis, Parsley, Pathology, Permissible exposure limit, Petroleum jelly, Phenprocoumon, Phospholipid, Phytomenadione, Placenta, Platelet, Point-of-care testing, Polymorphism (biology), Pregnancy, Preterm birth, Protein C, Protein Data Bank, Protein S, Protein Z, Prothrombin complex concentrate, Prothrombin time, Pulmonary embolism, Purpura fulminans, Racemic mixture, Radiography, Rat, Recommended exposure limit, Redox, Renal function, Rib fracture, Rivaroxaban, Rodent, Rodenticide, Royal Pharmaceutical Society of Great Britain, Rubiaceae, Science History Institute, Scoliosis, Serum albumin, Silage, Simvastatin, Skeleton, Spasticity, Spinal cord, Stillbirth, Stroke, Systematic review, Talc, Tautomer, Teratology, Therapeutic index, Thrombin, Thrombophilia, Thrombosis, Thrombus, Thyroid, United States Government Publishing Office, United States Navy, University of Wisconsin–Madison, Valvular heart disease, Vampire bat, Vertebral column, Vertebral compression fracture, Veterinary medicine, Viscosity, Vitamin K, Vitamin K epoxide reductase, VKORC1, Warfarin necrosis, WHO Model List of Essential Medicines, Wisconsin Alumni Research Foundation, Ximelagatran, Zygosity, 4-Hydroxycoumarin. Expand index (169 more) »

Acenocoumarol

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin).

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Acta Crystallographica

Acta Crystallographica is a series of peer-reviewed scientific journals, with articles centred on crystallography, published by the International Union of Crystallography (IUCr).

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Adverse drug reaction

An adverse drug reaction (ADR) is an injury caused by taking a medication.

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Allele

An allele is a variant form of a given gene.

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American College of Chest Physicians

The American College of Chest Physicians (CHEST) is a medical association in the United States consisting of physicians and non-physician specialists in the field of chest medicine, which includes pulmonology, critical care medicine, and sleep medicine.

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Anticoagulant

Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time.

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Antiphospholipid syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by antiphospholipid antibodies.

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Antiplatelet drug

An antiplatelet drug (antiaggregant) is a member of a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus formation.

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Antithrombin

Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system.

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Apiaceae

Apiaceae or Umbelliferae, is a family of mostly aromatic flowering plants named after the type genus Apium and commonly known as the celery, carrot or parsley family, or simply as umbellifers.

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Apixaban

Apixaban, sold under the tradename Eliquis, is an anticoagulant for the treatment of venous thromboembolic events.

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Aromaticity

In organic chemistry, the term aromaticity is used to describe a cyclic (ring-shaped), planar (flat) molecule with a ring of resonance bonds that exhibits more stability than other geometric or connective arrangements with the same set of atoms.

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Artificial heart valve

An artificial heart valve is a device implanted in the heart of a patient with valvular heart disease.

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Aspirin

Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation.

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Atrial fibrillation

Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm characterized by rapid and irregular beating of the atria.

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Bait (luring substance)

Bait is any substance used to attract prey, e.g. in a mousetrap.

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Bioaccumulation

Bioaccumulation is the accumulation of substances, such as pesticides, or other chemicals in an organism.

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Biological half-life

The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.

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Bird of prey

A bird of prey, predatory bird, or raptor is any of several species of bird that hunts and feeds on rodents and other animals.

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Birth defect

A birth defect, also known as a congenital disorder, is a condition present at birth regardless of its cause.

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Bleeding

Bleeding, also known as hemorrhaging or haemorrhaging, is blood escaping from the circulatory system.

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Bone density

Bone density, or bone mineral density (BMD), is the amount of bone mineral in bone tissue.

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Bone fracture

A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a partial or complete break in the continuity of the bone.

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Borage

Borage (Borago officinalis), also known as a starflower, is an annual herb in the flowering plant family Boraginaceae.

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Borage seed oil

Borage seed oil is derived from the seeds of the Borago officinalis (borage).

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Brachydactyly

Brachydactyly (Greek βραχύς.

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Broad-spectrum antibiotic

The term broad-spectrum antibiotic can refer to an antibiotic that acts on the two major bacterial groups, gram-positive and gram-negative, or any antibiotic that acts against a wide range of disease-causing bacteria.

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Broccoli

Broccoli is an edible green plant in the cabbage family whose large flowering head is eaten as a vegetable.

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Brodifacoum

Brodifacoum is a highly lethal 4-hydroxycoumarin vitamin K antagonist anticoagulant poison.

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Cabbage

Cabbage or headed cabbage (comprising several cultivars of Brassica oleracea) is a leafy green, red (purple), or white (pale green) biennial plant grown as an annual vegetable crop for its dense-leaved heads.

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Calcaneus

In humans, the calcaneus (from the Latin calcaneus or calcaneum, meaning heel) or heel bone is a bone of the tarsus of the foot which constitutes the heel.

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Calcification

Calcification is the accumulation of calcium salts in a body tissue.

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Calcium

Calcium is a chemical element with symbol Ca and atomic number 20.

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Caucasian race

The Caucasian race (also Caucasoid or Europid) is a grouping of human beings historically regarded as a biological taxon, which, depending on which of the historical race classifications used, have usually included some or all of the ancient and modern populations of Europe, the Caucasus, Asia Minor, North Africa, the Horn of Africa, Western Asia, Central Asia and South Asia.

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Centers for Disease Control and Prevention

The Centers for Disease Control and Prevention (CDC) is the leading national public health institute of the United States.

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Centers for Medicare and Medicaid Services

The Centers for Medicare & Medicaid Services (CMS), previously known as the Health Care Financing Administration (HCFA), is a federal agency within the United States Department of Health and Human Services (HHS) that administers the Medicare program and works in partnership with state governments to administer Medicaid, the Children's Health Insurance Program (CHIP), and health insurance portability standards.

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Central nervous system

The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.

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Cholesterol

Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.

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Cholesterol embolism

Cholesterol embolism (often cholesterol crystal embolism or atheroembolism, sometimes blue toe or purple toe syndrome or trash foot or warfarin blue toe syndrome) occurs when cholesterol is released, usually from an atherosclerotic plaque, and travels as an embolus in the bloodstream to lodge (as an embolism) causing an obstruction in blood vessels further away.

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Clopidogrel

Clopidogrel, sold as the brandname Plavix among others, is an antiplatelet medication that is used to reduce the risk of heart disease and stroke in those at high risk.

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Coagulation

Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.

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Committee on Safety of Medicines

The Committee on Safety of Medicines (CSM) was an independent advisory committee that advised the UK Licensing Authority on the quality, efficacy and safety of medicines.

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Contraindication

In medicine, a contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient.

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Coriander

Coriander (Coriandrum sativum), also known as cilantro or Chinese parsley, is an annual herb in the family Apiaceae.

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Coumarin

Coumarin (2H-chromen-2-one) is a fragrant organic chemical compound in the benzopyrone chemical class, although it may also be seen as a subclass of lactones.

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Coumatetralyl

Coumatetralyl is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type used as a rodenticide.

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Cranberry

Cranberries are a group of evergreen dwarf shrubs or trailing vines in the subgenus Oxycoccus of the genus Vaccinium.

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Cruciferous vegetables

Cruciferous vegetables are vegetables of the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivars being raised for food production such as cauliflower, cabbage, garden cress, bok choy, broccoli, Brussels sprouts and similar green leaf vegetables.

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CYP1A2

Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.

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CYP2C19

Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme.

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CYP2C9

Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.

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CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.

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Dabigatran

Dabigatran, sold under the brand name Pradaxa among others, is an anticoagulant medication which can be taken by mouth.

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Deep vein thrombosis

Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly the legs.

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Department of Conservation (New Zealand)

The Department of Conservation (DOC) (Māori: Te Papa Atawhai) is the public service department of New Zealand charged with the conservation of New Zealand's natural and historical heritage.

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Des-gamma carboxyprothrombin

Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin.

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Developing country

A developing country (or a low and middle income country (LMIC), less developed country, less economically developed country (LEDC), underdeveloped country) is a country with a less developed industrial base and a low Human Development Index (HDI) relative to other countries.

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Developmental disability

Developmental disability is a diverse group of chronic conditions that are due to mental or physical impairments that arise before adulthood.

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Dicoumarol

Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant that functions as a functional vitamin K depleter (similar to warfarin, a drug that dicoumarol inspired).

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Diet (nutrition)

In nutrition, diet is the sum of food consumed by a person or other organism.

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Dill

Dill (Anethum graveolens) is an annual herb in the celery family Apiaceae.

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Dipteryx odorata

Dipteryx odorata (commonly known as "cumaru" or "kumaru") is a species of flowering tree in the pea family, Fabaceae.

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Drug interaction

A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together.

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Drug metabolism

Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.

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Dwight D. Eisenhower

Dwight David "Ike" Eisenhower (October 14, 1890 – March 28, 1969) was an American army general and statesman who served as the 34th President of the United States from 1953 to 1961.

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Dysmelia

Dysmelia (from Gr. δυσ- dys, "bad" + μέλ|ος mél|os, "limb" + Eng. suff. -ia) is a congenital disorder of a limb resulting from a disturbance in embryonic development.

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Edoxaban

Edoxaban (DU-176b, trade names Savaysa, Lixiana) is an oral anticoagulant drug which acts as a direct factor Xa inhibitor.

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Embolism

An embolism is the lodging of an embolus, a blockage-causing piece of material, inside a blood vessel.

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Emergency Planning and Community Right-to-Know Act

The Emergency Planning and Community Right-to-Know Act of 1986 is a United States federal law passed by the 99th United States Congress located at Title 42, Chapter 116 of the U.S. Code, concerned with emergency response preparedness.

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Enantiomer

In chemistry, an enantiomer, also known as an optical isomer (and archaically termed antipode or optical antipode), is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).

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Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Enoxaparin sodium

Enoxaparin sodium, sold under the brand name Lovenox among others, is an anticoagulant medication (blood thinner).

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Enzyme

Enzymes are macromolecular biological catalysts.

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Enzyme induction and inhibition

Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme.

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Enzyme inhibitor

4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Epileptic seizure

An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

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Factor IX

Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1.

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Factor V

Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor.

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Factor VII

Factor VII (blood-coagulation factor VIIa, activated blood coagulation factor VII, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade.

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Factor VIII

Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF).

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Factor X

Factor X, also known by the eponym Stuart–Prower factor, is an enzyme of the coagulation cascade.

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Femur

The femur (pl. femurs or femora) or thigh bone, is the most proximal (closest to the hip joint) bone of the leg in tetrapod vertebrates capable of walking or jumping, such as most land mammals, birds, many reptiles including lizards, and amphibians such as frogs.

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Fetal warfarin syndrome

Fetal Warfarin syndrome is a disorder of the embryo which occurs in a child whose mother took the medication warfarin (brand name: Coumadin) during pregnancy.

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Food and Drug Administration

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

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Formaldehyde

No description.

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Frank Schofield

Dr.

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Fresh frozen plasma

Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood.

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Galium odoratum

Galium odoratum, the sweetscented bedstraw, is a flowering perennial plant in the family Rubiaceae, native to much of Europe from Spain and Ireland to Russia, as well as Western Siberia, Turkey, Iran, the Caucasus, China and Japan.

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Gamma-glutamyl carboxylase

Gamma-glutamyl carboxylase is an enzyme that in humans is encoded by the GGCX gene, located on chromosome 2 at 2p12.

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Gangrene

Gangrene is a type of tissue death caused by a lack of blood supply.

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Generic drug

A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.

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Ginger

Ginger (Zingiber officinale) is a flowering plant whose rhizome, ginger root or simply ginger, is widely used as a spice or a folk medicine.

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Ginkgo biloba

Ginkgo biloba, commonly known as ginkgo or gingko (both pronounced), also known as the maidenhair tree, is the only living species in the division Ginkgophyta, all others being extinct.

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Ginseng

Ginseng is the root of plants in the genus Panax, such as Korean ginseng (P. ginseng), South China ginseng (P. notoginseng), and American ginseng (P. quinquefolius), typically characterized by the presence of ginsenosides and gintonin.

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Glutamic acid

Glutamic acid (symbol Glu or E) is an α-amino acid with formula.

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Google Books

Google Books (previously known as Google Book Search and Google Print and by its codename Project Ocean) is a service from Google Inc. that searches the full text of books and magazines that Google has scanned, converted to text using optical character recognition (OCR), and stored in its digital database.

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Gut flora

Gut flora, or gut microbiota, or gastrointestinal microbiota, is the complex community of microorganisms that live in the digestive tracts of humans and other animals, including insects.

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HAS-BLED

HAS-BLED is a scoring system developed to assess 1-year risk of major bleeding in patients taking anticoagulants with atrial fibrillation.

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Health system

A health system, also sometimes referred to as health care system or as healthcare system, is the organization of people, institutions, and resources that deliver health care services to meet the health needs of target populations.

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Hemiacetal

A hemiacetal or a hemiketal is a compound that results from the addition of an alcohol to an aldehyde or a ketone, respectively.

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Hemodialysis

Hemodialysis, also spelled haemodialysis, commonly called kidney dialysis or simply dialysis, is a process of purifying the blood of a person whose kidneys are not working normally.

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Heparin

Heparin, also known as unfractionated heparin (UFH), is medication which is used as an anticoagulant (blood thinner).

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Heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count), due to the administration of various forms of heparin, an anticoagulant.

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Hepatotoxicity

Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.

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Hierochloe odorata

Hierochloe odorata or Anthoxanthum nitens (commonly known as sweet grass, manna grass, Mary’s grass or vanilla grass, and as holy grass in the UK, bison grass e.g. by Polish vodka producers) is an aromatic herb native to northern Eurasia and North America.

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Human–wildlife conflict

Human–wildlife conflict refers to the interaction between wild animals and people and the resultant negative impact on people or their resources, or wild animals or their habitat.

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Hypericum perforatum

Hypericum perforatum, known as perforate St John's-wort, common Saint John's wort and St John's wort, is a flowering plant in the family Hypericaceae.

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Hyperthyroidism

Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland.

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Hypoplasia

Hypoplasia (from Ancient Greek ὑπo- hypo-, "under" + πλάσις plasis, "formation"; adjective form hypoplastic) is underdevelopment or incomplete development of a tissue or organ.

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Hypothyroidism

Hypothyroidism, also called underactive thyroid or low thyroid, is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone.

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Idarucizumab

Idarucizumab (BI 655075), sold under the brand name Praxbind, is a monoclonal antibody designed for the reversal of anticoagulant effects of dabigatran.

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Immediately dangerous to life or health

The term immediately dangerous to life or health (IDLH) is defined by the US National Institute for Occupational Safety and Health (NIOSH) as exposure to airborne contaminants that is "likely to cause death or immediate or delayed permanent adverse health effects or prevent escape from such an environment." Examples include smoke or other poisonous gases at sufficiently high concentrations.

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In utero

In utero is a Latin term literally meaning "in the womb" or "in the uterus".

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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Joseph Stalin

Joseph Vissarionovich Stalin (18 December 1878 – 5 March 1953) was a Soviet revolutionary and politician of Georgian nationality.

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Karl Paul Link

Karl Paul Gerhard Link (31 January 1901 – 21 November 1978) was an American biochemist best known for his discovery of the anticoagulant warfarin.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Lavandula

Lavandula (common name lavender) is a genus of 47 known species of flowering plants in the mint family, Lamiaceae.

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Lavrentiy Beria

Lavrentiy Pavlovich Beria (p; tr,; 29 March 1899 – 23 December 1953) was a Soviet politician, Marshal of the Soviet Union and state security administrator, chief of the Soviet security and secret police apparatus (NKVD) under Joseph Stalin during World War II, and promoted to deputy premier under Stalin from 1941.

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Liquorice

Liquorice (British English) or licorice (American English) is the root of Glycyrrhiza glabra from which a sweet flavour can be extracted.

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List of extremely hazardous substances

This is the list of extremely hazardous substances defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002).

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Low birth weight

Low birth weight (LBW) is defined by the World Health Organization as a birth weight of a infant of 2,499 g or less, regardless of gestational age.

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Low molecular weight heparin

Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications.

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Macrolide

The macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached.

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Maintenance dose

A maintenance dose is the maintenance rate of drug administration equal to the rate of elimination at steady state.

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Matrix gla protein

Matrix gla protein (MGP) is member of a family of vitamin-K2 dependent, Gla-containing proteins.

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Mechanism of action

In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.

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Medical guideline

A medical guideline (also called a clinical guideline or clinical practice line) is a document with the aim of guiding decisions and criteria regarding diagnosis, management, and treatment in specific areas of healthcare.

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Medicare (United States)

In the United States, Medicare is a national health insurance program, now administered by the Centers for Medicaid and Medicare Services of the U.S. federal government but begun in 1966 under the Social Security Administration.

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Melilotus

Melilotus, known as melilot, sweet clover, and kumoniga (from the Cumans),Bulgarian Folk Customs, Mercia MacDermott, pg 27 is a genus in the family Fabaceae (the same family that also includes the Trifolium clovers).

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Meta-analysis

A meta-analysis is a statistical analysis that combines the results of multiple scientific studies.

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Metronidazole

Metronidazole, marketed under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication.

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Miscarriage

Miscarriage, also known as spontaneous abortion and pregnancy loss, is the natural death of an embryo or fetus before it is able to survive independently.

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Mist net

Mist nets are used by ornithologists and bat biologists to capture wild birds and bats for banding or other research projects.

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Mouse

A mouse (Mus), plural mice, is a small rodent characteristically having a pointed snout, small rounded ears, a body-length scaly tail and a high breeding rate.

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Mycotoxin

A mycotoxin (from the Greek μύκης mykes, "fungus" and τοξικόν toxikon, "poison") is a toxic secondary metabolite produced by organisms of the fungus kingdom and is capable of causing disease and death in both humans and other animals.

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Myocardial infarction

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.

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Nasal bridge

The nasal bridge is the upper, bony part of the human nose, which overlies the nasal bones.

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National Institute for Occupational Safety and Health

The National Institute for Occupational Safety and Health (NIOSH) is the United States federal agency responsible for conducting research and making recommendations for the prevention of work-related injury and illness.

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Nature (journal)

Nature is a British multidisciplinary scientific journal, first published on 4 November 1869.

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Necrosis

Necrosis (from the Greek νέκρωσις "death, the stage of dying, the act of killing" from νεκρός "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.

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Nikita Khrushchev

Nikita Sergeyevich Khrushchev (15 April 1894 – 11 September 1971) was a Soviet statesman who led the Soviet Union during part of the Cold War as the First Secretary of the Communist Party of the Soviet Union from 1953 to 1964, and as Chairman of the Council of Ministers, or Premier, from 1958 to 1964.

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Nonsteroidal anti-inflammatory drug

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation.

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Occupational Safety and Health Administration

The Occupational Safety and Health Administration (OSHA) is an agency of the United States Department of Labor.

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Orthopedic surgery

Orthopedic surgery or orthopedics, also spelled orthopaedic, is the branch of surgery concerned with conditions involving the musculoskeletal system.

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Osteocalcin

Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein hormone found in bone and dentin.

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Osteoporosis

Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.

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Parsley

Parsley or garden parsley (Petroselinum crispum) is a species of flowering plant in the family Apiaceae, native to the central Mediterranean region (southern Italy, Greece, Portugal, Spain, Malta, Morocco, Algeria, and Tunisia), naturalized elsewhere in Europe, and widely cultivated as an herb, a spice, and a vegetable.

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Pathology

Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering" and -logia (-λογία), "study of") is a significant field in modern medical diagnosis and medical research, concerned mainly with the causal study of disease, whether caused by pathogens or non-infectious physiological disorder.

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Permissible exposure limit

The permissible exposure limit (PEL or OSHA PEL) is a legal limit in the United States for exposure of an employee to a chemical substance or physical agent such as loud noise.

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Petroleum jelly

Petroleum jelly, petrolatum, white petrolatum, soft paraffin/paraffin wax or multi-hydrocarbon, CAS number 8009-03-8, is a semi-solid mixture of hydrocarbons (with carbon numbers mainly higher than 25), originally promoted as a topical ointment for its healing properties.

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Phenprocoumon

Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin.

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Phospholipid

Phospholipids are a class of lipids that are a major component of all cell membranes.

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Phytomenadione

Phytomenadione, also known as vitamin K1 or phylloquinone, is a vitamin found in food and used as a dietary supplement.

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Placenta

The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.

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Platelet

Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

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Point-of-care testing

Point-of-care testing (POCT), or bedside testing is defined as medical diagnostic testing at or near the point of care—that is, at the time and place of patient care.

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Polymorphism (biology)

Polymorphism in biology and zoology is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species.

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Pregnancy

Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.

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Preterm birth

Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age.

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Protein C

Protein C, also known as autoprothrombin IIA and blood coagulation factor XIV, is a zymogen, the activated form of which plays an important role in regulating anticoagulation, inflammation, cell death, and maintaining the permeability of blood vessel walls in humans and other animals.

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Protein Data Bank

The Protein Data Bank (PDB) is a crystallographic database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids.

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Protein S

Protein S (also known as S-Protein) is a vitamin K-dependent plasma glycoprotein synthesized in the liver.

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Protein Z

Protein Z (PZ or PROZ) is a protein which in humans is encoded by the PROZ gene.

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Prothrombin complex concentrate

Prothrombin complex concentrate (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, IX, and X. Some versions also contain factor VII.

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Prothrombin time

The prothrombin time (PT)—along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR)—are assays evaluating the extrinsic pathway of coagulation.

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Pulmonary embolism

Pulmonary embolism (PE) is a blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (embolism).

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Purpura fulminans

Purpura fulminans is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation.

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Racemic mixture

In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.

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Radiography

Radiography is an imaging technique using X-rays to view the internal form of an object.

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Rat

Rats are various medium-sized, long-tailed rodents in the superfamily Muroidea.

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Recommended exposure limit

A recommended exposure limit (REL) is an occupational exposure limit that has been recommended by the United States National Institute for Occupational Safety and Health to the Occupational Safety and Health Administration (OSHA) for adoption as a permissible exposure limit.

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Redox

Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.

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Renal function

Renal function, in nephrology, is an indication of the kidney's condition and its role in renal physiology.

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Rib fracture

A rib fracture is a break in a rib bone.

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Rivaroxaban

Rivaroxaban, sold under the brand name Xarelto, among others, is an oral anticoagulant medication (blood thinner).

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Rodent

Rodents (from Latin rodere, "to gnaw") are mammals of the order Rodentia, which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws.

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Rodenticide

Rodenticides, colloquially rat poison, are typically non-specific pest control chemicals made and sold for the purpose of killing rodents.

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Royal Pharmaceutical Society of Great Britain

The Royal Pharmaceutical Society of Great Britain (RPSGB) existed from its founding as the Pharmaceutical Society of Great Britain in 1841 until 2010.

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Rubiaceae

The Rubiaceae are a family of flowering plants, commonly known as the coffee, madder, or bedstraw family.

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Science History Institute

The Science History Institute is an institution that preserves and promotes understanding of the history of science.

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Scoliosis

Scoliosis is a medical condition in which a person's spine has a sideways curve.

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Serum albumin

Serum albumin, often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood.

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Silage

Silage is fermented, high-moisture stored fodder which can be fed to cattle, sheep and other such ruminants (cud-chewing animals) or used as a biofuel feedstock for anaerobic digesters.

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Simvastatin

Simvastatin, marketed under the trade name Zocor among others, is a lipid-lowering medication.

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Skeleton

The skeleton is the body part that forms the supporting structure of an organism.

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Spasticity

Spasticity is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia.

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Spinal cord

The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column.

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Stillbirth

Stillbirth is typically defined as fetal death at or after 20 to 28 weeks of pregnancy.

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Stroke

A stroke is a medical condition in which poor blood flow to the brain results in cell death.

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Systematic review

Systematic reviews are a type of literature review that uses systematic methods to collect secondary data, critically appraise research studies, and synthesize studies.

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Talc

Talc or talcum is a clay mineral composed of hydrated magnesium silicate with the chemical formula H2Mg3(SiO3)4 or Mg3Si4O10(OH)2.

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Tautomer

Tautomers are constitutional isomers of organic compounds that readily interconvert.

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Teratology

Teratology is the study of abnormalities of physiological development.

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Therapeutic index

The therapeutic index (TI; also referred to as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity.

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Thrombin

Thrombin (fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.

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Thrombophilia

Thrombophilia (sometimes hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels).

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Thrombosis

Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

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Thrombus

A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.

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Thyroid

The thyroid gland, or simply the thyroid, is an endocrine gland in the neck, consisting of two lobes connected by an isthmus.

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United States Government Publishing Office

The United States Government Publishing Office (GPO) (formerly the Government Printing Office) is an agency of the legislative branch of the United States federal government.

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United States Navy

The United States Navy (USN) is the naval warfare service branch of the United States Armed Forces and one of the seven uniformed services of the United States.

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University of Wisconsin–Madison

The University of Wisconsin–Madison (also known as University of Wisconsin, Wisconsin, UW, or regionally as UW–Madison, or simply Madison) is a public research university in Madison, Wisconsin, United States.

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Valvular heart disease

Valvular heart disease is any disease process involving one or more of the four valves of the heart (the aortic and bicuspid valves on the left side of heart and the pulmonary and tricuspid valves on the right side of heart. These conditions occur largely as a consequence of aging,Burden of valvular heart diseases: a population-based study. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano. Lancet. 2006 Sep;368(9540):1005-11. but may also be the result of congenital (inborn) abnormalities or specific disease or physiologic processes including rheumatic heart disease and pregnancy. Anatomically, the valves are part of the dense connective tissue of the heart known as the cardiac skeleton and are responsible for the regulation of blood flow through the heart and great vessels. Valve failure or dysfunction can result in diminished heart functionality, though the particular consequences are dependent on the type and severity of valvular disease. Treatment of damaged valves may involve medication alone, but often involves surgical valve repair (valvuloplasty) or replacement (insertion of an artificial heart valve).

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Vampire bat

Vampire bats are bats whose food source is blood, a dietary trait called hematophagy.

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Vertebral column

The vertebral column, also known as the backbone or spine, is part of the axial skeleton.

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Vertebral compression fracture

A compression fracture is a collapse of a vertebra.

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Veterinary medicine

Veterinary medicine is the branch of medicine that deals with the prevention, diagnosis and treatment of disease, disorder and injury in non-human animals.

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Viscosity

The viscosity of a fluid is the measure of its resistance to gradual deformation by shear stress or tensile stress.

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Vitamin K

Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body requires for complete synthesis of certain proteins that are prerequisites for blood coagulation (K from Koagulation, Danish for "coagulation") and which the body also needs for controlling binding of calcium in bones and other tissues.

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Vitamin K epoxide reductase

Vitamin K epoxide reductase (VKOR) is an enzyme that reduces vitamin K after it has been oxidised in the carboxylation of glutamic acid residues in blood coagulation enzymes.

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VKORC1

The human gene VKORC1 encodes for the enzyme, Vitamin K epOxide Reductase Complex (VKORC) subunit 1.

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Warfarin necrosis

Warfarin-induced skin necrosis (or, more generally, Anticoagulant-induced skin necrosis) is a condition in which skin and subcutaneous tissue necrosis (tissue death) occurs due to acquired protein C deficiency following treatment with anti-vitamin K anticoagulants (4-hydroxycoumarins, such as warfarin).

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WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.

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Wisconsin Alumni Research Foundation

The Wisconsin Alumni Research Foundation is the independent nonprofit technology transfer organization serving the University of Wisconsin–Madison and Morgridge Institute for Research.

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Ximelagatran

Ximelagatran (Exanta or Exarta, H 376/95) is an anticoagulant that has been investigated extensively as a replacement for warfarin that would overcome the problematic dietary, drug interaction, and monitoring issues associated with warfarin therapy.

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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4-Hydroxycoumarin

4-Hydroxycoumarin is a coumarin derivative with a hydroxy group at the 4-position.

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Redirects here:

ATC code B01AA03, ATCvet code QB01AA03, Athrombin, Athrombin-K, Athrombine-K, Brumolin, Co-Rax, Coumadin, Coumadins, Coumafen, Coumafene, Coumaphen, Coumaphene, Coumefene, Coumiden, Cumadin, Cumiden, Dethmor, Dethnel, Dicusat E, Frass-Ratron, Jantoven, Kumader, Kumadu, Kumatox, Kypfarin, Latka 42, Mar-Frin, Marevan, Maveran, Panwarfin, Place-Pax, Prothromadin, Rosex, S-warfarin, Sodium Coumadin, Sodium coumadin, Sofarin, Solfarin, Sorexa Plus, Temus W, Tintorane, Tox-Hid, Vampirinip II, Vampirinip III, Waran, Warf 42, Warfarat, Warfarin overdose, Warfarin potassium, Warfarin sodium, Warfarine, Warferin, Warficide, Warfilone, Zoocoumarin.

References

[1] https://en.wikipedia.org/wiki/Warfarin

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