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History of molecular biology

Index History of molecular biology

The history of molecular biology begins in the 1930s with the convergence of various, previously distinct biological and physical disciplines: biochemistry, genetics, microbiology, virology and physics. [1]

201 relations: Ada Yonath, Albumin, Alexander Rich, Alfred Hershey, Alfred Mirsky, Alpha helix, Amino acid, Antoine François, comte de Fourcroy, Armour and Company, Arne Tiselius, Atomic theory, Avery–MacLeod–McCarty experiment, Bacteriophage, Beta sheet, Biochemistry, Biomolecular structure, Biophysics, Blood, California Institute of Technology, Carl Correns, Catalysis, Cavendish Laboratory, Central dogma of molecular biology, Christian B. Anfinsen, Circular dichroism, Coagulation, Colloid, Cryogenic electron microscopy, Crystallography, Cybernetics, Cyclol, Denaturation (biochemistry), Deoxyribose, Digestion, DNA, Dorothy Maud Wrinch, Drosophila melanogaster, Eduard Buchner, Edward Tatum, Edwin Joseph Cohn, Egg white, Electron microscope, Electrophoresis, Elemental analysis, Emil Abderhalden, Empirical formula, Enterobacteria phage T2, Enzyme, Erich von Tschermak, Erwin Chargaff, ..., Erwin Schrödinger, Fascism, Fibrin, Flocculation, Flow birefringence, François Jacob, Francis Crick, Franz Hofmeister, Frederic M. Richards, Frederick Griffith, Frederick Sanger, Friedrich Miescher, Gene, Gene expression, Genetic code, Genetic engineering, Genetics, Genome, George Beadle, Gerardus Johannes Mulder, Gilbert Smithson Adair, Gluten, Greek language, Gregor Mendel, Griffith's experiment, Group I catalytic intron, Group II intron, Guy's Hospital, Hammerhead ribozyme, Har Gobind Khorana, Hemoglobin, Hermann Emil Fischer, Hershey–Chase experiment, History of biology, History of biotechnology, History of genetics, Hsien Wu, Hugo de Vries, Hydrogen bond, Hydrophobe, Information theory, Insulin, Irving Langmuir, Jacques Monod, James Watson, Jöns Jacob Berzelius, Jennifer Doudna, John Desmond Bernal, Justus von Liebig, Kaj Ulrik Linderstrøm-Lang, Karl Zimmer, King's College London, Latin, Lawrence Bragg, Leucine, Lily E. Kay, Linus Pauling, Macromolecular assembly, Macromolecule, Marianne Grunberg-Manago, Martha Chase, Mass spectrometry, Maurice Wilkins, Max Delbrück, Mendelian inheritance, Meselson–Stahl experiment, Messenger RNA, Metabolism, Microbiology, Model organism, Molecular biology, Mortimer Louis Anson, Mutation, Nature (journal), Nazism, Nenad Ban, Neurospora crassa, News Chronicle, Niels Bohr, Nikolai Koltsov, Nikolay Timofeev-Ressovsky, Nobel Prize in Chemistry, Nobel Prize in Physiology or Medicine, Nuclear magnetic resonance, Nuclear magnetic resonance spectroscopy of proteins, Nucleic acid, Nucleotide, Osmotic pressure, Oswald Avery, Pancreatic ribonuclease, Peptide, Peptide bond, Peptidyl transferase, Peter Ritchie Calder, Phage group, Phoebus Levene, Physics, Pliny the Elder, Polyamine, Polynucleotide phosphorylase, Post-translational modification, Precipitation (chemistry), Protein, Protein Data Bank, Protein domain, Protein purification, Protein structure prediction, Quantum mechanics, Radiobiology, Red blood cell, Ribonuclease P, Ribose, Ribosome, Ribozyme, Richard Altmann, Richard E. Dickerson, Robert W. Holley, Rockefeller Foundation, Rockefeller University, Rosalind Franklin, Serum albumin, Sickle cell disease, Sidney Altman, Slaughterhouse, Solvay Conference, Spermine, Tetraloop, The New York Times, Theodor Svedberg, Thermodynamic free energy, Thomas A. Steitz, Thomas Cech, Thomas Hunt Morgan, Torbjörn Caspersson, Toxin, Transfer RNA, Ultracentrifuge, Unified atomic mass unit, University of Cambridge, Varsity (Cambridge), Venkatraman Ramakrishnan, Virology, Walter Kauzmann, Warren Weaver, Wheat, William Astbury, Wolfgang Ostwald, World War II, X-ray, X-ray crystallography, Zygosity. Expand index (151 more) »

Ada Yonath

Ada E. Yonath (עדה יונת.) (born 22 June 1939) is an Israeli crystallographer best known for her pioneering work on the structure of the ribosome.

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Albumin

The albumins (formed from Latin: albumen "(egg) white; dried egg white") are a family of globular proteins, the most common of which are the serum albumins.

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Alexander Rich

Alexander Rich (November 15, 1924 – April 27, 2015) was an American biologist and biophysicist.

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Alfred Hershey

Alfred Day Hershey (December 4, 1908 – May 22, 1997) was an American Nobel Prize–winning bacteriologist and geneticist.

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Alfred Mirsky

Alfred Ezra Mirsky (October 17, 1900 – June 19, 1974) was an American pioneer in molecular biology.

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Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Antoine François, comte de Fourcroy

Antoine François, comte de Fourcroy (15 June 175516 December 1809) was a French chemist and a contemporary of Antoine Lavoisier.

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Armour and Company

Armour & Company was an American company that used to be one of the five leading firms in the meat packing industry.

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Arne Tiselius

Arne Wilhelm Kaurin Tiselius (10 August 1902 – 29 October 1971) was a Swedish biochemist who won the Nobel Prize in Chemistry in 1948 "for his research on electrophoresis and adsorption analysis, especially for his discoveries concerning the complex nature of the serum proteins.".

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Atomic theory

In chemistry and physics, atomic theory is a scientific theory of the nature of matter, which states that matter is composed of discrete units called atoms.

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Avery–MacLeod–McCarty experiment

The Avery–MacLeod–McCarty experiment was an experimental demonstration, reported in 1944 by Oswald Avery, Colin MacLeod, and Maclyn McCarty, that DNA is the substance that causes bacterial transformation, in an era when it had been widely believed that it was proteins that served the function of carrying genetic information (with the very word protein itself coined to indicate a belief that its function was primary).

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Bacteriophage

A bacteriophage, also known informally as a phage, is a virus that infects and replicates within Bacteria and Archaea.

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Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

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Biochemistry

Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms.

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Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.

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Biophysics

Biophysics is an interdisciplinary science that applies the approaches and methods of physics to study biological systems.

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Blood

Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.

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California Institute of Technology

The California Institute of Technology (abbreviated Caltech)The university itself only spells its short form as "Caltech"; other spellings such as.

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Carl Correns

Carl Erich Correns (19 September 1864 – 14 February 1933) was a German botanist and geneticist, who is notable primarily for his independent discovery of the principles of heredity, and for his rediscovery of Gregor Mendel's earlier paper on that subject, which he achieved simultaneously but independently of the botanists Erich Tschermak von Seysenegg and Hugo de Vries, and the agronomist William Jasper Spillman.

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Catalysis

Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.

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Cavendish Laboratory

The Cavendish Laboratory is the Department of Physics at the University of Cambridge, and is part of the School of Physical Sciences.

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Central dogma of molecular biology

The central dogma of molecular biology is an explanation of the flow of genetic information within a biological system.

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Christian B. Anfinsen

Christian Boehmer Anfinsen Jr. (March 26, 1916 – May 14, 1995) was an American biochemist.

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Circular dichroism

Circular dichroism (CD) is dichroism involving circularly polarized light, i.e., the differential absorption of left- and right-handed light.

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Coagulation

Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.

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Colloid

In chemistry, a colloid is a mixture in which one substance of microscopically dispersed insoluble particles is suspended throughout another substance.

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Cryogenic electron microscopy

Electron cryomicroscopy (CryoEM) is an electron microscopy (EM) technique where the sample is cooled to cryogenic temperatures.

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Crystallography

Crystallography is the experimental science of determining the arrangement of atoms in crystalline solids (see crystal structure).

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Cybernetics

Cybernetics is a transdisciplinary approach for exploring regulatory systems—their structures, constraints, and possibilities.

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Cyclol

The cyclol hypothesis is the first structural model of a folded, globular protein.

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Denaturation (biochemistry)

Denaturation is a process in which proteins or nucleic acids lose the quaternary structure, tertiary structure, and secondary structure which is present in their native state, by application of some external stress or compound such as a strong acid or base, a concentrated inorganic salt, an organic solvent (e.g., alcohol or chloroform), radiation or heat.

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Deoxyribose

Deoxyribose, or more precisely 2-deoxyribose, is a monosaccharide with idealized formula H−(C.

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Digestion

Digestion is the breakdown of large insoluble food molecules into small water-soluble food molecules so that they can be absorbed into the watery blood plasma.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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Dorothy Maud Wrinch

Dorothy Maud Wrinch (12 September 1894 – 11 February 1976; married names Nicholson, Glaser) was a mathematician and biochemical theorist best known for her attempt to deduce protein structure using mathematical principles.

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Drosophila melanogaster

Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.

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Eduard Buchner

Eduard Buchner (20 May 1860 – 13 August 1917) was a German chemist and zymologist, awarded the 1907 Nobel Prize in Chemistry for his work on fermentation.

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Edward Tatum

Edward Lawrie Tatum (December 14, 1909 – November 5, 1975) was an American geneticist.

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Edwin Joseph Cohn

Edwin Joseph Cohn (December 17, 1892 – October 1, 1953) was an early protein scientist.

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Egg white

Egg white is the clear liquid (also called the albumen or the glair/glaire) contained within an egg.

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Electron microscope

An electron microscope is a microscope that uses a beam of accelerated electrons as a source of illumination.

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Electrophoresis

Electrophoresis (from the Greek "Ηλεκτροφόρηση" meaning "to bear electrons") is the motion of dispersed particles relative to a fluid under the influence of a spatially uniform electric field.

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Elemental analysis

Elemental analysis is a process where a sample of some material (e.g., soil, waste or drinking water, bodily fluids, minerals, chemical compounds) is analyzed for its elemental and sometimes isotopic composition.

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Emil Abderhalden

Emil Abderhalden (March 9, 1877 – August 5, 1950) was a Swiss biochemist and physiologist.

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Empirical formula

In chemistry, the empirical formula of a chemical compound is the simplest positive integer ratio of atoms present in a compound.

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Enterobacteria phage T2

Enterobacteria phage T2 is a virus that infects and kills E. coli.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Erich von Tschermak

Erich Tschermak, Edler von Seysenegg (15 November 1871 – 11 October 1962) was an Austrian agronomist who developed several new disease-resistant crops, including wheat-rye and oat hybrids.

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Erwin Chargaff

Erwin Chargaff (11 August 1905 – 20 June 2002) was an Austro-Hungarian biochemist who immigrated to the United States during the Nazi era and was a professor of biochemistry at Columbia University medical school.

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Erwin Schrödinger

Erwin Rudolf Josef Alexander Schrödinger (12 August 1887 – 4 January 1961), sometimes written as or, was a Nobel Prize-winning Austrian physicist who developed a number of fundamental results in the field of quantum theory, which formed the basis of wave mechanics: he formulated the wave equation (stationary and time-dependent Schrödinger equation) and revealed the identity of his development of the formalism and matrix mechanics.

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Fascism

Fascism is a form of radical authoritarian ultranationalism, characterized by dictatorial power, forcible suppression of opposition and control of industry and commerce, which came to prominence in early 20th-century Europe.

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Fibrin

Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.

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Flocculation

Flocculation, in the field of chemistry, is a process wherein colloids come out of suspension in the form of floc or flake, either spontaneously or due to the addition of a clarifying agent.

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Flow birefringence

In biochemistry, flow birefringence is a hydrodynamic technique for measuring the rotational diffusion constants (or, equivalently, the rotational drag coefficients).

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François Jacob

François Jacob (17 June 1920 – 19 April 2013) was a French biologist who, together with Jacques Monod, originated the idea that control of enzyme levels in all cells occurs through regulation of transcription.

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Francis Crick

Francis Harry Compton Crick (8 June 1916 – 28 July 2004) was a British molecular biologist, biophysicist, and neuroscientist, most noted for being a co-discoverer of the structure of the DNA molecule in 1953 with James Watson, work which was based partly on fundamental studies done by Rosalind Franklin, Raymond Gosling and Maurice Wilkins.

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Franz Hofmeister

Franz Hofmeister (30 August 1850, Prague – 26 July 1922, Würzburg) was an early protein scientist, and is famous for his studies of salts that influence the solubility and conformational stability of proteins.

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Frederic M. Richards

Frederic Middlebrook Richards (August 19, 1925 – January 11, 2009), commonly referred to as Fred Richards, was an American biochemist and biophysicist known for solving the pioneering crystal structure of the ribonuclease S enzyme in 1967 and for defining the concept of solvent-accessible surface.

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Frederick Griffith

Frederick Griffith was a British bacteriologist whose focus was the epidemiology and pathology of bacterial pneumonia.

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Frederick Sanger

Frederick Sanger (13 August 1918 – 19 November 2013) was a British biochemist who twice won the Nobel Prize in Chemistry, one of only two people to have done so in the same category (the other is John Bardeen in physics), the fourth person overall with two Nobel Prizes, and the third person overall with two Nobel Prizes in the sciences.

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Friedrich Miescher

Johannes Friedrich Miescher (13 August 1844 – 26 August 1895) was a Swiss physician and biologist.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.

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Genetic code

The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or mRNA sequences) into proteins.

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Genetic engineering

Genetic engineering, also called genetic modification or genetic manipulation, is the direct manipulation of an organism's genes using biotechnology.

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Genetics

Genetics is the study of genes, genetic variation, and heredity in living organisms.

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Genome

In the fields of molecular biology and genetics, a genome is the genetic material of an organism.

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George Beadle

George Wells Beadle (October 22, 1903 – June 9, 1989) was an American scientist in the field of genetics, and Nobel Prize in Physiology or Medicine Nobel laureate who with Edward Tatum discovered the role of genes in regulating biochemical events within cells in 1958.

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Gerardus Johannes Mulder

Gerardus Johannes Mulder (27 December 1802 – 18 April 1880) was a Dutch organic and analytical chemist.

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Gilbert Smithson Adair

Gilbert Smithson Adair FRS (1896–1979) was an early protein scientist who used osmotic pressure measurements to establish that haemoglobin was a tetramer under physiological conditions.

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Gluten

Gluten (from Latin gluten, "glue") is a composite of storage proteins termed prolamins and glutelins and stored together with starch in the endosperm (which nourishes the embryonic plant during germination) of various cereal (grass) grains.

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Greek language

Greek (Modern Greek: ελληνικά, elliniká, "Greek", ελληνική γλώσσα, ellinikí glóssa, "Greek language") is an independent branch of the Indo-European family of languages, native to Greece and other parts of the Eastern Mediterranean and the Black Sea.

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Gregor Mendel

Gregor Johann Mendel (Řehoř Jan Mendel; 20 July 1822 – 6 January 1884) was a scientist, Augustinian friar and abbot of St. Thomas' Abbey in Brno, Margraviate of Moravia.

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Griffith's experiment

Griffith's experiment, reported in 1928 by Frederick Griffith, was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.

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Group I catalytic intron

Group I introns are large self-splicing ribozymes.

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Group II intron

Group II introns are a large class of self-catalytic ribozymes and mobile genetic elements found within the genes of all three domains of life.

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Guy's Hospital

Guy's Hospital is an NHS hospital in the borough of Southwark in central London.

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Hammerhead ribozyme

The hammerhead ribozyme is an RNA motif that catalyzes reversible cleavage and ligation reactions at a specific site within an RNA molecule.

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Har Gobind Khorana

Har Gobind Khorana (9 January 1922 – 9 November 2011) was an Indian American biochemist.

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Hemoglobin

Hemoglobin (American) or haemoglobin (British); abbreviated Hb or Hgb, is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates (with the exception of the fish family Channichthyidae) as well as the tissues of some invertebrates.

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Hermann Emil Fischer

Hermann Emil Louis Fischer FRS FRSE FCS (9 October 1852 – 15 July 1919) was a German chemist and 1902 recipient of the Nobel Prize in Chemistry.

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Hershey–Chase experiment

The Hershey–Chase experiments were a series of experiments conducted in 1952 by Alfred Hershey and Martha Chase that helped to confirm that DNA is genetic material.

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History of biology

The history of biology traces the study of the living world from ancient to modern times.

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History of biotechnology

Biotechnology is the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services.

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History of genetics

The history of genetics dates from the classical era with contributions by Hippocrates, Aristotle and Epicurus.

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Hsien Wu

Hsien Wu (24 November 1893 – 8 August 1959) was a Chinese protein scientist.

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Hugo de Vries

Hugo Marie de Vries ForMemRS (16 February 1848 – 21 May 1935) was a Dutch botanist and one of the first geneticists.

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Hydrogen bond

A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.

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Hydrophobe

In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.

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Information theory

Information theory studies the quantification, storage, and communication of information.

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Insulin

Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.

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Irving Langmuir

Irving Langmuir (January 31, 1881 – August 16, 1957) was an American chemist and physicist.

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Jacques Monod

Jacques Lucien Monod (February 9, 1910 – May 31, 1976), a French biochemist, won the Nobel Prize in Physiology or Medicine in 1965, sharing it with François Jacob and Andre Lwoff "for their discoveries concerning genetic control of enzyme and virus synthesis".

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James Watson

James Dewey Watson (born April 6, 1928) is an American molecular biologist, geneticist and zoologist, best known as one of the co-discoverers of the structure of DNA in 1953 with Francis Crick and Rosalind Franklin.

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Jöns Jacob Berzelius

Baron Jöns Jacob Berzelius (20 August 1779 – 7 August 1848), named by himself and contemporary society as Jacob Berzelius, was a Swedish chemist.

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Jennifer Doudna

Jennifer Anne Doudna (born 19 February 1964) is an American biochemist, professor of chemistry at the Department of Chemistry and Chemical Engineering, and Professor of Biochemistry and Molecular Biology at the Department of Molecular and Cell Biology at the University of California, Berkeley.

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John Desmond Bernal

John Desmond Bernal (10 May 1901 – 15 September 1971) was an Irish scientist who pioneered the use of X-ray crystallography in molecular biology.

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Justus von Liebig

Justus Freiherr von Liebig (12 May 1803 – 18 April 1873) was a German chemist who made major contributions to agricultural and biological chemistry, and was considered the founder of organic chemistry.

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Kaj Ulrik Linderstrøm-Lang

Kaj Ulrik Linderstrøm-Lang (29 November 1896 – 25 May 1959) was a Danish protein scientist, who was the director of the Carlsberg Laboratory from 1939 until his death.

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Karl Zimmer

Karl Günter Zimmer (12 July 1911 – 29 February 1988) was a German physicist and radiation biologist, known for his work on the effects of ionizing radiation on DNA.

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King's College London

King's College London (informally King's or KCL) is a public research university located in London, United Kingdom, and a founding constituent college of the federal University of London.

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Latin

Latin (Latin: lingua latīna) is a classical language belonging to the Italic branch of the Indo-European languages.

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Lawrence Bragg

Sir William Lawrence Bragg, (31 March 1890 – 1 July 1971) was an Australian-born British physicist and X-ray crystallographer, discoverer (1912) of Bragg's law of X-ray diffraction, which is basic for the determination of crystal structure.

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Leucine

Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.

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Lily E. Kay

Lily E. Kay (May 22, 1947 – December 18, 2000) was a historian of science noted for her studies of molecular biology.

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Linus Pauling

Linus Carl Pauling (February 28, 1901 – August 19, 1994) was an American chemist, biochemist, peace activist, author, educator, and husband of American human rights activist Ava Helen Pauling.

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Macromolecular assembly

The term macromolecular assembly (MA) refers to massive chemical structures such as viruses and non-biologic nanoparticles, cellular organelles and membranes and ribosomes, etc.

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Macromolecule

A macromolecule is a very large molecule, such as protein, commonly created by the polymerization of smaller subunits (monomers).

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Marianne Grunberg-Manago

Marianne Grunberg-Manago (January 6, 1921 – January 3, 2013) was a Soviet-born French biochemist.

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Martha Chase

Martha Cowles Chase (November 30, 1927 – August 8, 2003), also known as Martha C. Epstein, was an American geneticist known for having in 1952, with Alfred Hershey, experimentally helped to confirm that DNA rather than protein is the genetic material of life.

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Mass spectrometry

Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio.

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Maurice Wilkins

Maurice Hugh Frederick Wilkins (15 December 1916 – 5 October 2004) was a New Zealand-born British physicist and molecular biologist, and Nobel laureate whose research contributed to the scientific understanding of phosphorescence, isotope separation, optical microscopy and X-ray diffraction, and to the development of radar.

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Max Delbrück

Max Ludwig Henning Delbrück (September 4, 1906 – March 9, 1981), a German–American biophysicist, helped launch the molecular biology research program in the late 1930s.

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Mendelian inheritance

Mendelian inheritance is a type of biological inheritance that follows the laws originally proposed by Gregor Mendel in 1865 and 1866 and re-discovered in 1900.

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Meselson–Stahl experiment

The Meselson–Stahl experiment is an experiment by Matthew Meselson and Franklin Stahl in 1958 which supported Watson and Crick's hypothesis that DNA replication was semiconservative.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Microbiology

Microbiology (from Greek μῑκρος, mīkros, "small"; βίος, bios, "life"; and -λογία, -logia) is the study of microorganisms, those being unicellular (single cell), multicellular (cell colony), or acellular (lacking cells).

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Model organism

A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.

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Molecular biology

Molecular biology is a branch of biology which concerns the molecular basis of biological activity between biomolecules in the various systems of a cell, including the interactions between DNA, RNA, proteins and their biosynthesis, as well as the regulation of these interactions.

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Mortimer Louis Anson

Mortimer (Tim) Louis Anson (1901 – 16 October 1968) was an early protein scientist.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Nature (journal)

Nature is a British multidisciplinary scientific journal, first published on 4 November 1869.

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Nazism

National Socialism (Nationalsozialismus), more commonly known as Nazism, is the ideology and practices associated with the Nazi Party – officially the National Socialist German Workers' Party (Nationalsozialistische Deutsche Arbeiterpartei or NSDAP) – in Nazi Germany, and of other far-right groups with similar aims.

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Nenad Ban

Nenad Ban is a Croatian biochemist born in Zagreb, Croatia who currently works at the ETH Zurich, Swiss Federal Institute of Technology, as a professor of Structural Molecular Biology.

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Neurospora crassa

Neurospora crassa is a type of red bread mold of the phylum Ascomycota.

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News Chronicle

The News Chronicle was a British daily newspaper.

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Niels Bohr

Niels Henrik David Bohr (7 October 1885 – 18 November 1962) was a Danish physicist who made foundational contributions to understanding atomic structure and quantum theory, for which he received the Nobel Prize in Physics in 1922.

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Nikolai Koltsov

Nikolai Konstantinovich Koltsov (Николай Константинович Кольцов; July 14, 1872December 2, 1940) was a Russian biologist and a pioneer of modern genetics.

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Nikolay Timofeev-Ressovsky

Nikolaj Vladimirovich Timofeev-Resovskij (Николай Владимирович Тимофеев-Ресовский; – 28 March 1981) was a Soviet biologist.

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Nobel Prize in Chemistry

The Nobel Prize in Chemistry (Nobelpriset i kemi) is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry.

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Nobel Prize in Physiology or Medicine

The Nobel Prize in Physiology or Medicine (Nobelpriset i fysiologi eller medicin), administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the fields of life sciences and medicine.

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Nuclear magnetic resonance

Nuclear magnetic resonance (NMR) is a physical phenomenon in which nuclei in a magnetic field absorb and re-emit electromagnetic radiation.

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Nuclear magnetic resonance spectroscopy of proteins

Nuclear magnetic resonance spectroscopy of proteins (usually abbreviated protein NMR) is a field of structural biology in which NMR spectroscopy is used to obtain information about the structure and dynamics of proteins, and also nucleic acids, and their complexes.

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Nucleic acid

Nucleic acids are biopolymers, or small biomolecules, essential to all known forms of life.

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Nucleotide

Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.

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Osmotic pressure

Osmotic pressure is the minimum pressure which needs to be applied to a solution to prevent the inward flow of its pure solvent across a semipermeable membrane.

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Oswald Avery

Oswald Theodore Avery Jr. (October 21, 1877 – February 20, 1955) was a Canadian-American physician and medical researcher.

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Pancreatic ribonuclease

Pancreatic ribonucleases (RNase, RNase I, RNase A, pancreatic RNase, ribonuclease I, endoribonuclease I, ribonucleic phosphatase, alkaline ribonuclease, ribonuclease, gene S glycoproteins, Ceratitis capitata alkaline ribonuclease, SLSG glycoproteins, gene S locus-specific glycoproteins, S-genotype-assocd. glycoproteins, ribonucleate 3'-pyrimidino-oligonucleotidohydrolase) are pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles.

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Peptide

Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.

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Peptide bond

A peptide bond is a covalent chemical bond linking two consecutive amino acid monomers along a peptide or protein chain.

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Peptidyl transferase

The peptidyl transferase is an aminoacyltransferase as well as the primary enzymatic function of the ribosome, which forms peptide bonds between adjacent amino acids using tRNAs during the translation process of protein biosynthesis.

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Peter Ritchie Calder

Peter Ritchie Calder, Baron Ritchie-Calder (1 July 1906 – 31 January 1982) was a Scottish socialist author, journalist and academic.

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Phage group

The phage group (sometimes called the American Phage Group) was an informal network of biologists centered on Max Delbrück that contributed heavily to bacterial genetics and the origins of molecular biology in the mid-20th century.

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Phoebus Levene

Phoebus Aaron Theodore Levene, M.D. (25 February 1869 – 6 September 1940) was an American biochemist who studied the structure and function of nucleic acids.

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Physics

Physics (from knowledge of nature, from φύσις phýsis "nature") is the natural science that studies matterAt the start of The Feynman Lectures on Physics, Richard Feynman offers the atomic hypothesis as the single most prolific scientific concept: "If, in some cataclysm, all scientific knowledge were to be destroyed one sentence what statement would contain the most information in the fewest words? I believe it is that all things are made up of atoms – little particles that move around in perpetual motion, attracting each other when they are a little distance apart, but repelling upon being squeezed into one another..." and its motion and behavior through space and time and that studies the related entities of energy and force."Physical science is that department of knowledge which relates to the order of nature, or, in other words, to the regular succession of events." Physics is one of the most fundamental scientific disciplines, and its main goal is to understand how the universe behaves."Physics is one of the most fundamental of the sciences. Scientists of all disciplines use the ideas of physics, including chemists who study the structure of molecules, paleontologists who try to reconstruct how dinosaurs walked, and climatologists who study how human activities affect the atmosphere and oceans. Physics is also the foundation of all engineering and technology. No engineer could design a flat-screen TV, an interplanetary spacecraft, or even a better mousetrap without first understanding the basic laws of physics. (...) You will come to see physics as a towering achievement of the human intellect in its quest to understand our world and ourselves."Physics is an experimental science. Physicists observe the phenomena of nature and try to find patterns that relate these phenomena.""Physics is the study of your world and the world and universe around you." Physics is one of the oldest academic disciplines and, through its inclusion of astronomy, perhaps the oldest. Over the last two millennia, physics, chemistry, biology, and certain branches of mathematics were a part of natural philosophy, but during the scientific revolution in the 17th century, these natural sciences emerged as unique research endeavors in their own right. Physics intersects with many interdisciplinary areas of research, such as biophysics and quantum chemistry, and the boundaries of physics are not rigidly defined. New ideas in physics often explain the fundamental mechanisms studied by other sciences and suggest new avenues of research in academic disciplines such as mathematics and philosophy. Advances in physics often enable advances in new technologies. For example, advances in the understanding of electromagnetism and nuclear physics led directly to the development of new products that have dramatically transformed modern-day society, such as television, computers, domestic appliances, and nuclear weapons; advances in thermodynamics led to the development of industrialization; and advances in mechanics inspired the development of calculus.

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Pliny the Elder

Pliny the Elder (born Gaius Plinius Secundus, AD 23–79) was a Roman author, naturalist and natural philosopher, a naval and army commander of the early Roman Empire, and friend of emperor Vespasian.

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Polyamine

A polyamine is an organic compound having more than two amino groups.

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Polynucleotide phosphorylase

Polynucleotide Phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity.

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Post-translational modification

Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.

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Precipitation (chemistry)

Precipitation is the creation of a solid from a solution.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein Data Bank

The Protein Data Bank (PDB) is a crystallographic database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Protein purification

Protein purification is a series of processes intended to isolate one or a few proteins from a complex mixture, usually cells, tissues or whole organisms.

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Protein structure prediction

Protein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence—that is, the prediction of its folding and its secondary and tertiary structure from its primary structure.

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Quantum mechanics

Quantum mechanics (QM; also known as quantum physics, quantum theory, the wave mechanical model, or matrix mechanics), including quantum field theory, is a fundamental theory in physics which describes nature at the smallest scales of energy levels of atoms and subatomic particles.

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Radiobiology

Radiobiology (also known as radiation biology) is a field of clinical and basic medical sciences that involves the study of the action of ionizing radiation on living things, especially health effects of radiation.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Ribonuclease P

Ribonuclease P (RNase P) is a type of ribonuclease which cleaves RNA.

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Ribose

Ribose is a carbohydrate with the formula C5H10O5; specifically, it is a pentose monosaccharide (simple sugar) with linear form H−(C.

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Ribosome

The ribosome is a complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis (translation).

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Ribozyme

Ribozymes (ribonucleic acid enzymes) are RNA molecules that are capable of catalyzing specific biochemical reactions, similar to the action of protein enzymes.

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Richard Altmann

Richard Altmann (12 March 1852 – 8 December 1900) was a German pathologist and histologist from Deutsch Eylau in the Province of Prussia.

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Richard E. Dickerson

Richard E. Dickerson (born 1931) is an American biochemist.

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Robert W. Holley

Robert William Holley (January 28, 1922 – February 11, 1993) was an American biochemist.

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Rockefeller Foundation

The Rockefeller Foundation is a private foundation based at 420 Fifth Avenue, New York City.

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Rockefeller University

The Rockefeller University is a center for scientific research, primarily in the biological and medical sciences, that provides doctoral and postdoctoral education.

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Rosalind Franklin

Rosalind Elsie Franklin (25 July 192016 April 1958) was an English chemist and X-ray crystallographer who made contributions to the understanding of the molecular structures of DNA (deoxyribonucleic acid), RNA (ribonucleic acid), viruses, coal, and graphite.

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Serum albumin

Serum albumin, often referred to simply as blood albumin, is an albumin (a type of globular protein) found in vertebrate blood.

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Sickle cell disease

Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents.

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Sidney Altman

Sidney Altman (born May 7, 1939) is a Canadian and American molecular biologist, who is the Sterling Professor of Molecular, Cellular, and Developmental Biology and Chemistry at Yale University.

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Slaughterhouse

A slaughterhouse or abattoir is a facility where animals are slaughtered for consumption as food.

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Solvay Conference

The International Solvay Institutes for Physics and Chemistry, located in Brussels, were founded by the Belgian industrialist Ernest Solvay in 1912, following the historic invitation-only 1911 Conseil Solvay, considered a turning point in the world of physics.

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Spermine

Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells.

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Tetraloop

Tetraloops are a type of four-base hairpin loop motifs in RNA secondary structure that cap many double helices.

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The New York Times

The New York Times (sometimes abbreviated as The NYT or The Times) is an American newspaper based in New York City with worldwide influence and readership.

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Theodor Svedberg

Theodor ("The") Svedberg (30 August 1884 – 25 February 1971) was a Swedish chemist and Nobel laureate, active at Uppsala University.

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Thermodynamic free energy

The thermodynamic free energy is the amount of work that a thermodynamic system can perform.

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Thomas A. Steitz

Thomas Arthur Steitz (born August 23, 1940) is a biochemist, a Sterling Professor of Molecular Biophysics and Biochemistry at Yale University, and investigator at the Howard Hughes Medical Institute, best known for his pioneering work on the ribosome.

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Thomas Cech

Thomas Robert Cech (born December 8, 1947) is an American chemist who shared the 1989 Nobel Prize in Chemistry with Sidney Altman, for their discovery of the catalytic properties of RNA.

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Thomas Hunt Morgan

Thomas Hunt Morgan (September 25, 1866 – December 4, 1945) was an American evolutionary biologist, geneticist, embryologist, and science author who won the Nobel Prize in Physiology or Medicine in 1933 for discoveries elucidating the role that the chromosome plays in heredity.

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Torbjörn Caspersson

Torbjörn Oskar Caspersson (15 October 1910 – 7 December 1997) was a Swedish cytologist and geneticist.

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Toxin

A toxin (from toxikon) is a poisonous substance produced within living cells or organisms; synthetic toxicants created by artificial processes are thus excluded.

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Transfer RNA

A transfer RNA (abbreviated tRNA and formerly referred to as sRNA, for soluble RNA) is an adaptor molecule composed of RNA, typically 76 to 90 nucleotides in length, that serves as the physical link between the mRNA and the amino acid sequence of proteins.

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Ultracentrifuge

The ultracentrifuge is a centrifuge optimized for spinning a rotor at very high speeds, capable of generating acceleration as high as (approx.). There are two kinds of ultracentrifuges, the preparative and the analytical ultracentrifuge.

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Unified atomic mass unit

The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).

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University of Cambridge

The University of Cambridge (informally Cambridge University)The corporate title of the university is The Chancellor, Masters, and Scholars of the University of Cambridge.

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Varsity (Cambridge)

Varsity is the oldest of Cambridge University's main student newspapers.

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Venkatraman Ramakrishnan

Venkatraman "Venki" Ramakrishnan (born 1952) is an American and British structural biologist of Indian origin.

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Virology

Virology is the study of viruses – submicroscopic, parasitic particles of genetic material contained in a protein coat – and virus-like agents.

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Walter Kauzmann

Walter J. Kauzmann (18 August 1916 – 27 January 2009) was an American chemist and professor emeritus of Princeton University.

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Warren Weaver

Warren Weaver (July 17, 1894 – November 24, 1978) was an American scientist, mathematician, and science administrator.

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Wheat

Wheat is a grass widely cultivated for its seed, a cereal grain which is a worldwide staple food.

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William Astbury

William Thomas Astbury FRS (also Bill Astbury; 25 February 1898, Longton – 4 June 1961, Leeds) was an English physicist and molecular biologist who made pioneering X-ray diffraction studies of biological molecules.

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Wolfgang Ostwald

Carl Wilhelm Wolfgang Ostwald (27 May 1883 – 22 November 1943) was a German chemist and biologist researching colloids.

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World War II

World War II (often abbreviated to WWII or WW2), also known as the Second World War, was a global war that lasted from 1939 to 1945, although conflicts reflecting the ideological clash between what would become the Allied and Axis blocs began earlier.

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X-ray

X-rays make up X-radiation, a form of electromagnetic radiation.

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X-ray crystallography

X-ray crystallography is a technique used for determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of incident X-rays to diffract into many specific directions.

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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Redirects here:

Discovery of DNA, Discovery of DNA structure, History of DNA biochemistry.

References

[1] https://en.wikipedia.org/wiki/History_of_molecular_biology

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