Table of Contents
195 relations: ABCG2, Acceptability, Actelion, Adipose tissue, Adverse effect, Ageing, Alcohol (drug), Aldehyde, Amine, Amitriptyline, Amprenavir, Antidepressant, Antidote, Antihistamine, Apalutamide, Appetite, Aprepitant, Aqueous solution, Area under the curve (pharmacokinetics), Atazanavir, Attention, Benzimidazole, Benzodiazepine, Binding selectivity, Bioavailability, Biological half-life, Biological target, Blood plasma, Blood–brain barrier, Boceprevir, Canada, Carbamazepine, Catalepsy, Center for Drug Evaluation and Research, Central nervous system depression, Chemical formula, Chemical nomenclature, Ciprofloxacin, Circadian rhythm, Citalopram, Clarithromycin, Clearance (pharmacology), Clinical trial, Cmax (pharmacology), Committee for Medicinal Products for Human Use, Conivaptan, Constipation, Contraindication, Controlled substance, Controlled Substances Act, ... Expand index (145 more) »
- Orexin antagonists
ABCG2
ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene.
Acceptability
Acceptability is the characteristic of a thing being subject to acceptance for some purpose.
See Daridorexant and Acceptability
Actelion
Actelion Pharmaceuticals Ltd. is a pharmaceuticals and biotechnology company established in December 1997, headquartered in Allschwil near Basel, Switzerland.
Adipose tissue
Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes.
See Daridorexant and Adipose tissue
Adverse effect
An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery.
See Daridorexant and Adverse effect
Ageing
Ageing (or aging in American English) is the process of becoming older.
Alcohol (drug)
Alcohol, sometimes referred to by the chemical name ethanol, is one of the most widely used and abused psychoactive drugs in the world and falls under the depressant category. Daridorexant and Alcohol (drug) are hypnotics.
See Daridorexant and Alcohol (drug)
Aldehyde
In organic chemistry, an aldehyde is an organic compound containing a functional group with the structure.
Amine
In chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair.
Amitriptyline
Amitriptyline, sold under the brand name Elavil among others, is a tricyclic antidepressant primarily used to treat major depressive disorder, and a variety of pain syndromes such as neuropathic pain, fibromyalgia, migraine and tension headaches.
See Daridorexant and Amitriptyline
Amprenavir
Amprenavir (original brand name Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection.
See Daridorexant and Amprenavir
Antidepressant
Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction.
See Daridorexant and Antidepressant
Antidote
An antidote is a substance that can counteract a form of poisoning.
Antihistamine
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies.
See Daridorexant and Antihistamine
Apalutamide
Apalutamide, sold under the brand name Erleada among others, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer.
See Daridorexant and Apalutamide
Appetite
Appetite is the desire to eat food items, usually due to hunger.
Aprepitant
Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting and to prevent postoperative nausea and vomiting. Daridorexant and Aprepitant are triazoles.
See Daridorexant and Aprepitant
Aqueous solution
An aqueous solution is a solution in which the solvent is water.
See Daridorexant and Aqueous solution
Area under the curve (pharmacokinetics)
In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry).
See Daridorexant and Area under the curve (pharmacokinetics)
Atazanavir
Atazanavir, sold under the brand name Reyataz among others, is an antiretroviral medication used to treat HIV/AIDS.
See Daridorexant and Atazanavir
Attention
Attention or focus, is the concentration of awareness on some phenomenon to the exclusion of other stimuli.
See Daridorexant and Attention
Benzimidazole
Benzimidazole is a heterocyclic aromatic organic compound. Daridorexant and Benzimidazole are Benzimidazoles.
See Daridorexant and Benzimidazole
Benzodiazepine
Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. Daridorexant and Benzodiazepine are hypnotics.
See Daridorexant and Benzodiazepine
Binding selectivity
In chemistry, binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
See Daridorexant and Binding selectivity
Bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation.
See Daridorexant and Bioavailability
Biological half-life
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (Cmax) to half of Cmax in the blood plasma.
See Daridorexant and Biological half-life
Biological target
A biological target is anything within a living organism to which some other entity (like an endogenous ligand or a drug) is directed and/or binds, resulting in a change in its behavior or function.
See Daridorexant and Biological target
Blood plasma
Blood plasma is a light amber-colored liquid component of blood in which blood cells are absent, but which contains proteins and other constituents of whole blood in suspension.
See Daridorexant and Blood plasma
Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood.
See Daridorexant and Blood–brain barrier
Boceprevir
Boceprevir (INN, trade name Victrelis) is a protease inhibitor used to treat hepatitis caused by hepatitis C virus (HCV) genotype 1. Daridorexant and Boceprevir are Pyrrolidines.
See Daridorexant and Boceprevir
Canada
Canada is a country in North America.
Carbamazepine
Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain.
See Daridorexant and Carbamazepine
Catalepsy
Catalepsy (from Ancient Greek, κατάληψις, "seizing, grasping") is a neurological condition characterized by muscular rigidity and fixity of posture regardless of external stimuli, as well as decreased sensitivity to pain.
See Daridorexant and Catalepsy
Center for Drug Evaluation and Research
The Center for Drug Evaluation and Research (CDER, pronounced "see'-der") is a division of the U.S. Food and Drug Administration (FDA) that monitors most drugs as defined in the Food, Drug, and Cosmetic Act.
See Daridorexant and Center for Drug Evaluation and Research
Central nervous system depression
Central nervous system (CNS) depression is a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness, possibly leading to coma or death.
See Daridorexant and Central nervous system depression
Chemical formula
A chemical formula is a way of presenting information about the chemical proportions of atoms that constitute a particular chemical compound or molecule, using chemical element symbols, numbers, and sometimes also other symbols, such as parentheses, dashes, brackets, commas and plus (+) and minus (−) signs.
See Daridorexant and Chemical formula
Chemical nomenclature
Chemical nomenclature is a set of rules to generate systematic names for chemical compounds.
See Daridorexant and Chemical nomenclature
Ciprofloxacin
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a number of bacterial infections.
See Daridorexant and Ciprofloxacin
Circadian rhythm
A circadian rhythm, or circadian cycle, is a natural oscillation that repeats roughly every 24 hours.
See Daridorexant and Circadian rhythm
Citalopram
Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
See Daridorexant and Citalopram
Clarithromycin
Clarithromycin, sold under the brand name Biaxin among others, is an antibiotic used to treat various bacterial infections.
See Daridorexant and Clarithromycin
Clearance (pharmacology)
In pharmacology, clearance (Cl_) is a pharmacokinetic parameter representing the efficiency of drug elimination.
See Daridorexant and Clearance (pharmacology)
Clinical trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison.
See Daridorexant and Clinical trial
Cmax (pharmacology)
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose.
See Daridorexant and Cmax (pharmacology)
Committee for Medicinal Products for Human Use
The Committee for Medicinal Products for Human Use (CHMP), formerly known as the Committee for Proprietary Medicinal Products (CPMP), is the European Medicines Agency's committee responsible for elaborating the agency's opinions on all issues regarding medicinal products for human use.
See Daridorexant and Committee for Medicinal Products for Human Use
Conivaptan
Conivaptan, sold under the brand name Vaprisol, is a non-peptide inhibitor of the receptor for anti-diuretic hormone, also called vasopressin.
See Daridorexant and Conivaptan
Constipation
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass.
See Daridorexant and Constipation
Contraindication
In medicine, a contraindication is a condition (a situation or factor) that serves as a reason not to take a certain medical treatment due to the harm that it would cause the patient.
See Daridorexant and Contraindication
Controlled substance
A controlled substance is generally a drug or chemical whose manufacture, possession and use is regulated by a government, such as illicitly used drugs or prescription medications that are designated by law.
See Daridorexant and Controlled substance
Controlled Substances Act
The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated.
See Daridorexant and Controlled Substances Act
Cyclic compound
A cyclic compound (or ring compound) is a term for a compound in the field of chemistry in which one or more series of atoms in the compound is connected to form a ring.
See Daridorexant and Cyclic compound
CYP2C19
Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein.
CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine, which in humans is encoded by CYP3A4 gene.
Cytochrome P450
Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases.
See Daridorexant and Cytochrome P450
Demethylation
Demethylation is the chemical process resulting in the removal of a methyl group (CH3) from a molecule.
See Daridorexant and Demethylation
Diltiazem
Diltiazem, sold under the brand name Cardizem among others, is a nondihydropyridine calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias.
See Daridorexant and Diltiazem
Dizziness
Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness.
See Daridorexant and Dizziness
Doxepin
Doxepin is a medication belonging to the tricyclic antidepressant (TCA) class of drugs used to treat major depressive disorder, anxiety disorders, chronic hives, and insomnia. Daridorexant and Doxepin are hypnotics.
Dronedarone
Dronedarone, sold under the brand name Multaq, is a class III antiarrhythmic medication developed by Sanofi-Aventis.
See Daridorexant and Dronedarone
Drug interaction
In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs.
See Daridorexant and Drug interaction
Drug liking
Drug liking is a measure of the pleasurable (hedonic) experience when a person consumes drugs.
See Daridorexant and Drug liking
Drug overdose
A drug overdose (overdose or OD) is the ingestion or application of a drug or other substance in quantities much greater than are recommended.
See Daridorexant and Drug overdose
Drug tolerance
Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use.
See Daridorexant and Drug tolerance
Drug withdrawal
Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome, is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs.
See Daridorexant and Drug withdrawal
Efavirenz
Efavirenz (EFV), sold under the brand names Sustiva among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
See Daridorexant and Efavirenz
Effect size
In statistics, an effect size is a value measuring the strength of the relationship between two variables in a population, or a sample-based estimate of that quantity.
See Daridorexant and Effect size
Efficacy
Efficacy is the ability to perform a task to a satisfactory or expected degree.
Elimination (pharmacology)
In pharmacology, the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.
See Daridorexant and Elimination (pharmacology)
Endogeny (biology)
Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell.
See Daridorexant and Endogeny (biology)
Enzalutamide
Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen (NSAA) medication which is used in the treatment of prostate cancer.
See Daridorexant and Enzalutamide
Enzyme
Enzymes are proteins that act as biological catalysts by accelerating chemical reactions.
Enzyme inducer
An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme.
See Daridorexant and Enzyme inducer
Enzyme inhibitor
An enzyme inhibitor is a molecule that binds to an enzyme and blocks its activity.
See Daridorexant and Enzyme inhibitor
Equinumerosity
In mathematics, two sets or classes A and B are equinumerous if there exists a one-to-one correspondence (or bijection) between them, that is, if there exists a function from A to B such that for every element y of B, there is exactly one element x of A with f(x).
See Daridorexant and Equinumerosity
Erythromycin
Erythromycin is an antibiotic used for the treatment of a number of bacterial infections. Daridorexant and Erythromycin are Ethers.
See Daridorexant and Erythromycin
Eszopiclone
Eszopiclone, sold under the brand name Lunesta among others, is a medication used in the treatment of insomnia.
See Daridorexant and Eszopiclone
European Medicines Agency
The European Medicines Agency (EMA) is an agency of the European Union (EU) in charge of the evaluation and supervision of pharmaceutical products.
See Daridorexant and European Medicines Agency
European Union
The European Union (EU) is a supranational political and economic union of member states that are located primarily in Europe.
See Daridorexant and European Union
Excretion
Excretion is elimination of metabolic waste, which is an essential process in all organisms.
See Daridorexant and Excretion
Famotidine
Famotidine, sold under the brand name Pepcid among others, is a histamine H2 receptor antagonist medication that decreases stomach acid production.
See Daridorexant and Famotidine
Fatigue
Fatigue describes a state of tiredness (which is not sleepiness), exhaustion or loss of energy.
Feces
Feces (or faeces;: faex) are the solid or semi-solid remains of food that was not digested in the small intestine, and has been broken down by bacteria in the large intestine.
Fluconazole
Fluconazole is an antifungal medication used for a number of fungal infections.
See Daridorexant and Fluconazole
Fluvoxamine
Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Daridorexant and Fluvoxamine are Ethers.
See Daridorexant and Fluvoxamine
Food and Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services.
See Daridorexant and Food and Drug Administration
Fosamprenavir
Fosamprenavir (FPV), sold under the brand names Lexiva and Telzir, is a medication used to treat HIV/AIDS.
See Daridorexant and Fosamprenavir
GABA receptor
The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory compound in the mature vertebrate central nervous system.
See Daridorexant and GABA receptor
Grapefruit juice
Grapefruit juice is the juice from grapefruits.
See Daridorexant and Grapefruit juice
Headache
Headache, also known as cephalalgia, is the symptom of pain in the face, head, or neck.
Hemiaminal
In organic chemistry, a hemiaminal (also carbinolamine) is a functional group or type of chemical compound that has a hydroxyl group and an amine attached to the same carbon atom:.
See Daridorexant and Hemiaminal
Hydrolysis
Hydrolysis is any chemical reaction in which a molecule of water breaks one or more chemical bonds.
See Daridorexant and Hydrolysis
Hydroxylation
In chemistry, hydroxylation can refer to.
See Daridorexant and Hydroxylation
Hypericum perforatum
Hypericum perforatum, commonly known as St John's wort (sometimes perforate St John's wort or common St John's wort), is a flowering plant in the family Hypericaceae.
See Daridorexant and Hypericum perforatum
Hypnotic
Hypnotic (from Greek Hypnos, sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia to produce and maintain unconsciousness, "sleep" is metaphorical as there are no regular sleep stages or cyclical natural states; patients rarely recover from anesthesia feeling refreshed and with renewed energy. Daridorexant and Hypnotic are hypnotics.
Hypocretin (orexin) receptor 1
Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.
See Daridorexant and Hypocretin (orexin) receptor 1
Hypocretin (orexin) receptor 2
Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene.
See Daridorexant and Hypocretin (orexin) receptor 2
Idorsia
Idorsia is a Swiss pharmaceutical research company in Allschwil, near Basel, Switzerland.
Imatinib
Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral targeted therapy medication used to treat cancer.
Indication (medicine)
In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery.
See Daridorexant and Indication (medicine)
Indinavir
Indinavir (IDV; trade name Crixivan, made by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS.
See Daridorexant and Indinavir
Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
Intramolecular reaction
In chemistry, intramolecular describes a process or characteristic limited within the structure of a single molecule, a property or phenomenon limited to the extent of a single molecule.
See Daridorexant and Intramolecular reaction
Itraconazole
Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. This includes aspergillosis, blastomycosis, coccidioidomycosis, histoplasmosis, and paracoccidioidomycosis. It may be given by mouth or intravenously. Common side effects include nausea, diarrhea, abdominal pain, rash, and headache.
See Daridorexant and Itraconazole
Ketoconazole
Ketoconazole, sold under the brand name Nizoral among others, is an antiandrogen, antifungal, and antiglucocorticoid medication used to treat a number of fungal infections.
See Daridorexant and Ketoconazole
Lateral hypothalamus
The lateral hypothalamus (LH), also called the lateral hypothalamic area (LHA), contains the primary orexinergic nucleus within the hypothalamus that widely projects throughout the nervous system; this system of neurons mediates an array of cognitive and physical processes, such as promoting feeding behavior and arousal, reducing pain perception, and regulating body temperature, digestive functions, and blood pressure, among many others.
See Daridorexant and Lateral hypothalamus
Lean body mass
Lean body mass (LBM), sometimes conflated with, is a component of body composition.
See Daridorexant and Lean body mass
Lemborexant
Lemborexant, sold under the brand name Dayvigo, is an orexin antagonist medication which is used in the treatment of insomnia. Daridorexant and Lemborexant are hypnotics and orexin antagonists.
See Daridorexant and Lemborexant
Ligand (biochemistry)
In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.
See Daridorexant and Ligand (biochemistry)
Lipophilicity
Lipophilicity (from Greek λίπος "fat" and φίλος "friendly") is the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents such as hexane or toluene.
See Daridorexant and Lipophilicity
Liver disease
Liver disease, or hepatic disease, is any of many diseases of the liver.
See Daridorexant and Liver disease
Lopinavir
Lopinavir is an antiretroviral of the protease inhibitor class.
See Daridorexant and Lopinavir
Martine Clozel
Martine Clozel (born 27 December 1955) is a scientist, entrepreneur and co-founder of Actelion and Idorsia.
See Daridorexant and Martine Clozel
Mechanism of action
In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect.
See Daridorexant and Mechanism of action
Medication
A medication (also called medicament, medicine, pharmaceutical drug, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease.
See Daridorexant and Medication
Medication discontinuation
Medication discontinuation is the ceasing of a medication treatment for a patient by either the clinician or the patient themself.
See Daridorexant and Medication discontinuation
Melatonin receptor agonist
Melatonin receptor agonists are analogues of melatonin that bind to and activate the melatonin receptor.
See Daridorexant and Melatonin receptor agonist
Meta-analysis
Meta-analysis is the statistical combination of the results of multiple studies addressing a similar research question.
See Daridorexant and Meta-analysis
Metabolism
Metabolism (from μεταβολή metabolÄ“, "change") is the set of life-sustaining chemical reactions in organisms.
See Daridorexant and Metabolism
Metabolite
In biochemistry, a metabolite is an intermediate or end product of metabolism.
See Daridorexant and Metabolite
Microsome
In cell biology, microsomes are heterogeneous vesicle-like artifacts (~20-200 nm diameter) re-formed from pieces of the endoplasmic reticulum (ER) when eukaryotic cells are broken-up in the laboratory; microsomes are not present in healthy, living cells.
See Daridorexant and Microsome
Midazolam
Midazolam, sold under the brand name Versed among others, is a benzodiazepine medication used for anesthesia, premedication before surgical anesthesia, and procedural sedation, and to treat severe agitation.
See Daridorexant and Midazolam
Middle-of-the-night insomnia
Middle-of-the-night insomnia (MOTN) is characterized by having difficulty returning to sleep after waking up during the night or very early in the morning.
See Daridorexant and Middle-of-the-night insomnia
Mirtazapine
Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression.
See Daridorexant and Mirtazapine
Molar mass
In chemistry, the molar mass (or molecular weight) of a chemical compound is defined as the ratio between the mass and the amount of substance (measured in moles) of any sample of the compound.
See Daridorexant and Molar mass
Monooxygenase
Monooxygenases are enzymes that incorporate one hydroxyl group (−OH) into substrates in many metabolic pathways.
See Daridorexant and Monooxygenase
Muscle weakness
Muscle weakness is a lack of muscle strength.
See Daridorexant and Muscle weakness
Narcolepsy
Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep.
See Daridorexant and Narcolepsy
Nausea
Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit.
Nefazodone
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant medication which is used in the treatment of depression and for other uses.
See Daridorexant and Nefazodone
Nelfinavir
Nelfinavir, sold under the brand name Viracept, is an antiretroviral medication used in the treatment of HIV/AIDS.
See Daridorexant and Nelfinavir
Neuropeptide
Neuropeptides are chemical messengers made up of small chains of amino acids that are synthesized and released by neurons.
See Daridorexant and Neuropeptide
Nonbenzodiazepine
Nonbenzodiazepines, sometimes referred to colloquially as Z-drugs (as many of their names begin with the letter "z"), are a class of psychoactive, depressant, sedative, hypnotic, anxiolytic drugs that are benzodiazepine-like in uses, such as for treating insomnia and anxiety. Daridorexant and Nonbenzodiazepine are hypnotics.
See Daridorexant and Nonbenzodiazepine
Opioid
Opioids are a class of drugs that derive from, or mimic, natural substances found in the opium poppy plant.
Oral administration
| name.
See Daridorexant and Oral administration
Orexin
Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite.
Orexin antagonist
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonis or DORA) of the orexin receptors, OX1 and OX2. Daridorexant and orexin antagonist are orexin antagonists.
See Daridorexant and Orexin antagonist
Orexin receptor
The orexin receptor (also referred to as the hypocretin receptor) is a G-protein-coupled receptor that binds the neuropeptide orexin.
See Daridorexant and Orexin receptor
Orexin-A
Orexin-A, also known as hypocretin-1, is a naturally occurring neuropeptide and orexin isoform.
Patent
A patent is a type of intellectual property that gives its owner the legal right to exclude others from making, using, or selling an invention for a limited period of time in exchange for publishing an enabling disclosure of the invention.
PH
In chemistry, pH, also referred to as acidity or basicity, historically denotes "potential of hydrogen" (or "power of hydrogen").
Pharmacodynamics
Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
See Daridorexant and Pharmacodynamics
Pharmacokinetics
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration.
See Daridorexant and Pharmacokinetics
Phenols
In organic chemistry, phenols, sometimes called phenolics, are a class of chemical compounds consisting of one or more hydroxyl groups (−O H) bonded directly to an aromatic hydrocarbon group.
Phenytoin
Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication.
See Daridorexant and Phenytoin
Physiologically based pharmacokinetic modelling
Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique for predicting the absorption, distribution, metabolism and excretion (ADME) of synthetic or natural chemical substances in humans and other animal species.
See Daridorexant and Physiologically based pharmacokinetic modelling
Placebo
A placebo is a substance or treatment which is designed to have no therapeutic value.
Plasma protein binding
Plasma protein binding refers to the degree to which medications attach to blood proteins within the blood plasma.
See Daridorexant and Plasma protein binding
Posaconazole
Posaconazole, sold under the brand name Noxafil among others, is a triazole antifungal medication.
See Daridorexant and Posaconazole
Post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a mental and behavioral disorder that develops from experiencing a traumatic event, such as sexual assault, warfare, traffic collisions, child abuse, domestic violence, or other threats on a person's life or well-being.
See Daridorexant and Post-traumatic stress disorder
Preclinical development
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals.
See Daridorexant and Preclinical development
Pyrrolidine
Pyrrolidine, also known as tetrahydropyrrole, is an organic compound with the molecular formula (CH2)4NH. Daridorexant and Pyrrolidine are Pyrrolidines.
See Daridorexant and Pyrrolidine
Ranitidine
Ranitidine, previously sold under the brand name Zantac among others, is a medication used to decrease stomach acid production.
See Daridorexant and Ranitidine
Rearrangement reaction
In organic chemistry, a rearrangement reaction is a broad class of organic reactions where the carbon skeleton of a molecule is rearranged to give a structural isomer of the original molecule.
See Daridorexant and Rearrangement reaction
Rebound effect
The rebound effect, or rebound phenomenon, is the emergence or re-emergence of symptoms that were either absent or controlled while taking a medication, but appear when that same medication is discontinued, or reduced in dosage.
See Daridorexant and Rebound effect
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
See Daridorexant and Receptor antagonist
Reward system
The reward system (the mesocorticolimbic circuit) is a group of neural structures responsible for incentive salience (i.e., "wanting"; desire or craving for a reward and motivation), associative learning (primarily positive reinforcement and classical conditioning), and positively-valenced emotions, particularly ones involving pleasure as a core component (e.g., joy, euphoria and ecstasy).
See Daridorexant and Reward system
Rifampicin
Rifampicin, also known as rifampin, is an ansamycin antibiotic used to treat several types of bacterial infections, including tuberculosis (TB), ''Mycobacterium avium'' complex, leprosy, and Legionnaires' disease.
See Daridorexant and Rifampicin
Ritonavir
Ritonavir, sold under the brand name Norvir, is an antiretroviral medication used along with other medications to treat HIV/AIDS.
See Daridorexant and Ritonavir
Rosuvastatin
Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids.
See Daridorexant and Rosuvastatin
Salt (chemistry)
In chemistry, a salt or ionic compound is a chemical compound consisting of an assembly of positively charged ions (cations) and negatively charged ions (anions), which results in a compound with no net electric charge (electrically neutral).
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Saquinavir
Saquinavir, sold under the brand name Invirase among others, is an antiretroviral medication used together with other medications to treat or prevent HIV/AIDS.
See Daridorexant and Saquinavir
Scientific literature
Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences.
See Daridorexant and Scientific literature
Sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.
Selective serotonin reuptake inhibitor
Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions.
See Daridorexant and Selective serotonin reuptake inhibitor
Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is unintended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
See Daridorexant and Side effect
Sleep
Sleep is a state of reduced mental and physical activity in which consciousness is altered and certain sensory activity is inhibited.
Sleep disorder
A sleep disorder, or somnipathy, is a medical disorder of an individual's sleep patterns.
See Daridorexant and Sleep disorder
Sleep onset
Sleep onset is the transition from wakefulness into sleep.
See Daridorexant and Sleep onset
Sleep onset latency
In sleep science, sleep onset latency (SOL) is the length of time that it takes to accomplish the transition from full wakefulness to sleep, normally to the lightest of the non-REM sleep stages.
See Daridorexant and Sleep onset latency
Sleep paralysis
Sleep paralysis is a state, during waking up or falling asleep, in which a person is conscious but in a complete state of full-body paralysis.
See Daridorexant and Sleep paralysis
Small molecule
In molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm.
See Daridorexant and Small molecule
Somnolence
Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
See Daridorexant and Somnolence
Substance abuse
Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others.
See Daridorexant and Substance abuse
Substance dependence
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption of the drug.
See Daridorexant and Substance dependence
Substrate (chemistry)
In chemistry, the term substrate is highly context-dependent.
See Daridorexant and Substrate (chemistry)
Suicidal ideation
Suicidal ideation, or suicidal thoughts, is the thought process of having ideas, or ruminations about the possibility of completing suicide.
See Daridorexant and Suicidal ideation
Suvorexant
Suvorexant, sold under the brand name Belsomra, is an orexin antagonist medication which is used in the treatment of insomnia. Daridorexant and Suvorexant are hypnotics, orexin antagonists and triazoles.
See Daridorexant and Suvorexant
Switzerland
Switzerland, officially the Swiss Confederation, is a landlocked country located in west-central Europe.
See Daridorexant and Switzerland
Systematic review
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic.
See Daridorexant and Systematic review
Tablet (pharmacy)
A tablet (also known as a pill) is a pharmaceutical oral dosage form (oral solid dosage, or OSD) or solid unit dosage form.
See Daridorexant and Tablet (pharmacy)
Telaprevir
Telaprevir (VX-950), marketed under the brand names Incivek and Incivo, is a pharmaceutical drug for the treatment of hepatitis C co-developed by Vertex Pharmaceuticals and Johnson & Johnson.
See Daridorexant and Telaprevir
Telithromycin
Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek.
See Daridorexant and Telithromycin
Therapy
A therapy or medical treatment is the attempted remediation of a health problem, usually following a medical diagnosis.
Tolerability
Tolerability refers to the degree to which overt adverse effects of a drug can be tolerated by a patient.
See Daridorexant and Tolerability
Trazodone
Trazodone, sold under many brand names, is an antidepressant medication. Daridorexant and Trazodone are hypnotics.
See Daridorexant and Trazodone
Tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
See Daridorexant and Tricyclic antidepressant
United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain, is a country in Northwestern Europe, off the coast of the continental mainland.
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United States Department of Defense
The United States Department of Defense (DoD, USDOD, or DOD) is an executive branch department of the federal government of the United States charged with coordinating and supervising all agencies and functions of the U.S. government directly related to national security and the United States Armed Forces.
See Daridorexant and United States Department of Defense
Urine
Urine is a liquid by-product of metabolism in humans and in many other animals.
Verapamil
Verapamil, sold under various trade names, is a calcium channel blocker medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia.
See Daridorexant and Verapamil
Volume of distribution
In pharmacology, the volume of distribution (VD, also known as apparent volume of distribution, literally, volume of dilution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.
See Daridorexant and Volume of distribution
Wakefulness
Wakefulness is a daily recurring brain state and state of consciousness in which an individual is conscious and engages in coherent cognitive and behavioral responses to the external world.
See Daridorexant and Wakefulness
Weight loss
Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue).
See Daridorexant and Weight loss
Zolpidem
Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems. Daridorexant and Zolpidem are hypnotics.
See also
Orexin antagonists
- ACT-335827
- ACT-462206
- ACT-539313
- Almorexant
- CVN45502
- Daridorexant
- EMPA (drug)
- Filorexant
- JNJ-10397049
- JNJ-61393215
- Lemborexant
- Orexin antagonist
- RTIOX-276
- SB-334867
- SB-408124
- SB-649868
- Seltorexant
- Suvorexant
- TCS-OX2-29
- Vornorexant
References
Also known as ACT 541,468, ACT 541468, ACT-541,468, ACT-541468, ACT541468, Daridorexant HCL, Daridorexant hydrochloride, Nemorexant, QUVIVIQ.